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Biomedical subjects

B Burns

Publications and source records attributed to B Burns.

At least 55 records · Page 3Linked to original sources
PubMed1980

A comparison of laterality indices in college and retarded subjects.

The relation of laterality to intelligence was assessed by administration of Berman's ICD (Index of Cerebral Dominance) to 20 male and female college students and 20 retarded Ss (IQs 33-75) of comparable age and sex. The college Ss were more lateralized in hand, foot, ear, and eye, but it was primarily foot lateralization that distinguished the groups, despite the fact that hand was the most lateralized subsystem in both groups. While these results are not entirely consistent with Berman's, they are generally confirmatory of a positive relation of laterality and intelligence.

Brain↗
PubMed1979

Morphologic features of prognostic significance in uterine smooth muscle tumors: a review of eighty-four cases.

Independent microscopic review of the most cellular and pleomorphic areas of 84 smooth muscle tumors of the uterus by two pathologists yielded 23 leiomyosarcomas, 43 cellular leiomyomas, 16 bizarre leiomyomas, and two intravenous leiomyomas. Greater than 5 mitotic figures/10 high-power fields (hpf) correlated with malignant clinical behavior, but this occurred in only 75% of the leiomyosarcomas. Five cases with fewer than 5 mitoses/10 hpf pursued a malignant course. The mean age of the patients with malignant tumors (52.5 years) was similar to the mean age of those with bizarre leiomyomas (48.0 years) but those patients with cellular leiomyomas were significantly younger (42.0 years; p less than 0.01). Gross evidence of extrauterine extension was diagnostic of malignancy as was vascular invasion by anaplastic tumor. Fifteen of the 19 patients with leiomyosarcoma died of disease at an average of 28 months postoperatively. Inadequate sampling and interobserver variation are discussed.

Adult↗
PubMed1979

DLO2 in excised lungs perfused with blood containing sodium dithionite (Na2S2O4).

If the excised lung is perfused with blood containing the chemical sodium dithionite (DDT), the PO2 of pulmonary capillary blood is everywhere zero and the membrane diffusing capacity for O2 (DmO2) can be measured by a standard rebreathing technique. The reaction rate of DDT with O2 is not rate limiting in the DmO2. In 15--25 kg dogs anesthetized with pentobarbital sodium (30 mg/kg, iv), left lower lobe was excised, suspended horizontally and perfused with autologous blood at 25--27 degrees C. DDT was added to the blood and the rebreathing alveolar disappearance curves for O2 were measured. The DmO2 ranged from 6 to 43 (ml/min.Torr, STPD) at lung volumes of 240--780 ml (FRC at 6 cmH2O end-expiratory pressure). Lung weight, pulmonary artery pressure, and the DmO2 were stable in the presence of DDT. Histopathology indicates that dithionite in the concentrations used does not harm the lung. Effects of inequalities in the distributions of ventilation, volume, and diffusing capacity were examined in a two-compartment model and compared with the experimental findings.

Animals↗
PubMed1978

Evaluation of the central canal of the spinal cord in experimentally induced hydrocephalus.

The central canal of the spinal cord has been proposed as a significant compensatory alternative pathway of cerebrospinal fluid (CSF) flow in hydrocephalus. Ten dogs were made hydrocephalic by a relatively atraumatic experimental model that simulates the human circumstance of chronic communicating hydrocephalus. The central canal was studied by histopathology and compared with 10 normal control dogs. In both groups the central canal of the spinal cord was normal in size, configuration, and histological appearance. In this experimental model dilatation of the canal and increased movement of CSF does not appear to be a compensatory alternative pathway.

Animals↗
PubMed1977

The production of cerebrospinal fluid in experimental communicating hydrocephalus.

Utilizing an atraumatic model to produce chronic hydrocephalus, CSF production was measured during and after development of communicatin hydrocephalus. CSF volume production was significantly lower in animals with increased pressure. Animals with chronic hydrocephalus and normal pressures had abnormal CSF production. Diminished CSF production appears to offer a potential compensatory mechanism when CSF absorption is altered.

Animals↗
PubMed1977

The Wien effect in compensated metabolic acidosis.

CSF and blood acid-base values were measured in compensated metabolic acidosis, induced in anesthetized dogs by infusion of dilute HCl during hyperventilation. We observed cerebral blood flow-related steady-state differences in PCO2 between CSF and arterial venous blood from the brain. The steady-state values of CSF-blood PCO2 differences and blood H+ activity were intermediate to those observed by us previously during uncompensated acidosis and alkalosis (J. Appl. Physiol. 34: 249-254, 1973). These results are consistent with predictions of the "charged membrane hypothesis" proposed by us to explain CSF and blood acid-base relationship during uncompensated acid-base derangements (J. Appl. Physiol. 34: 243-248, 1973).

Acidosis↗
PubMed1977

Evaluation of cerebrospinal fluid production in the development of communicating hydrocephalus.

Diminished absorption of cerebrospinal fluid (CSF) is the most common cause of communicating hydrocephalus. Soon after the absorptive capacity is decreased, the CSF pressure increases, producing ventricular enlargement if the process is not halted. CSF production was measured by ventriculo-cisternal perfusion during and after the production of communicating hydrocephalus, using an atraumatic animal model. Animals with chronic hydrocephalus and normal pressure had normal CSF production. CSF production tended to be lower in animals with increased pressure. When CSF absorption is compromised, decreased CSF production does not appear to be a significant compensatory mechanism.

Acute Disease↗
PubMed1977

Saturation kinetics for steady-state pulmonary CO transfer.

Steady-state diffusing capacity of the lungs for carbon monoxide (DLCO) was measured in 13 anesthetized, paralyzed dogs ventilated at constant tidal volume and rate, using four different inspired CO levels (190, 600, 1,110, and 2,000 ppm). DLCO increased and reached a maximum as the inspired CO level was raised from 190 to 600 ppm. Further increases in inspired CO concentration were accompanied by a decrease in inspired CO concentration were accompanied by a decrease in DLCO. CO dead space and Pao2 remained constant at all inspired O2 levels. In some experiments a second set of measurements was made, the results of which were similar to those of the first set. The results cannot be explained by changes in CO back pressure, pulmonary capillary volume, or reaction rate of CO with hemoglobin, but can be explained if there is carrier-mediated CO transport in the alveolar capillary membrane.

Animals↗
PubMed1976

Mianserin hydrochloride: a novel antidepressant.

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.

Adjustment Disorders↗
PubMed1976

Activating posthypnotic conflict: emergent uncovering psychopathology repression, and psychopathology.

An attempt was made to observe the process of repression and symptom formation. Emergent uncovering techniques were used to weaken a spontaneous repression that was produced by the posthypnotic activation of sexual impulses stemming from an implanted oedipa paramnesia. Twelve hypnotic and ten simulating subjects were used in a modified real-simulator design. Although it was not possible to 'lift' the spontaneous repression of derivatives of oedipal strivings in the course of uncovering via visual imagery, a wide variety of spontaneous symptoms were produced in the hypnotically conditioned subjects. The type of symptom was shown to be related to the degree of repression. Simulating subjects produced only a few symptoms. The manifestation of a symptom was concomitant with an increase in the GSR, but not the blatancy of drive representation. These findings were consistent with the phenomena observed using free imagery in emergent uncovering psychotherapy.

Amnesia↗