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Biomedical subjects

B Borch-Iohnsen

Publications and source records attributed to B Borch-Iohnsen.

At least 19 recordsLinked to original sources
PubMed2005

Iron status among 3005 women aged 20-55 years in Central Norway: the Nord-Trøndelag Health Study (the HUNT study).

OBJECTIVE: To describe the iron status of Norwegian women of fertile age, to show the prevalence of iron-deficiency anemia and iron overload, and to demonstrate possible factors connected to and/or influencing iron status. MATERIAL AND METHODS: The diagnostic criteria were: (a) anemia: hemoglobin (Hb) < 120, < 117, or < 115 g/l; (b) depleted iron stores: serum ferritin (SF) < 10 or 12 microg/l; iron-deficiency anemia: (a)+(b). Iron overload: SF > or = 110 microg/l. The study was conducted in Central Norway where a total of 3005 women aged 20 to 55 years were enrolled in a health survey program (the HUNT Study). None of the women were pregnant and none had been blood donors in the two previous years. RESULTS: Median SF was 31.0 microg/l. Depleted iron stores were present in 10.9 and 15.1%, respectively. The Hb 2.5%tile among the iron-replete women was 117 g/l. With this cut-off value, anemia was present in 4.7% and iron-deficiency anemia in about 3%. Iron overload was present among 5.2%, and homozygous primary hemochromatosis among 0.4%. CONCLUSIONS: The prevalence of iron-deficiency anemia was relatively low and similar to that found earlier in small groups of Norwegian women. The prevalence is comparable with results from other developed countries.

Adult↗
PubMed2004

Headache prevalence related to haemoglobin and ferritin. The HUNT Study.

As clinic-based studies show an association between headache and both high and low levels of haemoglobin, we analysed this relationship in a population-based cross-sectional study (the HUNT Study). A total of 2385 women aged 20-55 years responded to a headache questionnaire and gave blood samples for measuring haemoglobin and ferritin. In the multivariate analyses, adjusting for age and education, there was a linear trend of decreasing prevalence of headache (P = 0.02) and migraine (P = 0.01) with decreasing haemoglobin. In particular, migraine was less likely among women with low haemoglobin (values < 11.5 g/dl) (odds ratio 0.4, confidence interval 0.2, 0.9). There was no correlation between headache prevalence and ferritin. The present findings may be relevant for the headache reported in polycythaemia and chronic altitude sickness.

Adult↗
PubMed2004

Iron status in a group of Norwegian children aged 6-24 months.

UNLABELLED: An adequate iron status is of vital importance for health and development in infancy and early childhood. Iron status was evaluated in a group of full-term Norwegian children followed longitudinally, at the ages of 6 mo (n = 278), 12 mo (n = 249) and 24 mo (n = 231) by measuring haemoglobin (Hb), mean cell volume (MCV) and serum ferritin. At 6, 12 and 24 mo of age, 3, 10 and 12%, respectively, had iron deficiency anaemia (IDA) defined as Hb <110 g/l in combination with ferritin <15 microg/l. With more restrictive criteria for defining IDA (Hb <110 g/l or <105 g/l in combination with ferritin <12 microg/l), the prevalence decreased to 1-2% at 6 mo and 2-5% at 12 and 24 mo of age. If children with a history of fever in the previous month were excluded, the proportion of children with depleted iron stores (ferritin <10 microg/l) increased from 2 to 3% at 6 mo, from 5 to 7% at 12 mo and from 9 to 13% at 24 mo. CONCLUSION: Mild iron deficiency anaemia exists among otherwise healthy Norwegian infants and toddlers. The prevention and early treatment of iron deficiency should be a priority for the child health services.

Age Factors↗
PubMed2001

[Should iron preparations be available only by prescription?].

Many persons associate fatigue and lassitude with iron deficiency and take extra iron "to be on the safe side". This is an unfortunate practice, as the early symptoms of iron deficiency anaemia and of hereditary iron overload (homozygous primary haemochromatosis) are similar. Primary haemochromatosis is considerably more prevalent than earlier believed. As many as 5 per 1,000 of the Norwegian population may have two mutated genes for haemochromatosis, while up to 15% may be carriers of a single mutated gene, and for these an extra intake of iron may be hazardous. The condition is highly underdiagnosed. In Norway at present, iron preparations of 60-100 mg are sold over the counter in pharmacies without prescription and often by self-service. However, no one should use iron tablets until iron deficiency and its cause has been ascertained. To avoid uncritical use of iron, iron preparations should be available only by doctor's prescription. Prolonged abuse of iron tablets may result in secondary haemochromatosis.

Adult↗
PubMed1997

[Primary hemochromatosis and dietary iron].

Primary haemochromatosis is characterized by an unusually high degree of iron absorption resulting in the accumulation of excessive amounts of tissue iron. Excess stores of iron are removed by repeated phlebotomy. Health personnel and a number of patients with primary haemochromatosis have expressed their desire for advice on special diets to try and reduce the number of phlebotomies per year. This article gives advice on how patients with primary haemochromatosis can decrease their dietary iron intake and how they can put together meals to obtain low bioavailability, and therefore a lower iron absorption. The diet should be varied and be rich in bread and cereals, and fruit and vegetables. The amount of meat, Norwegian brown whey cheese (iron supplemented) and alcohol should be limited. Tea or coffee with meals will reduce iron absorption. Food rich in ascorbic acid (fruit and fruit juice) should be avoided with meals. Ascorbic acid supplements are not recommended.

Hemochromatosis↗
PubMed1996

Influence of season and diet on liver and kidney content of essential elements and heavy metals in Svalbard reindeer.

Samples of liver (n = 78) and kidney (n = 60) from Svalbard reindeer (Rangifer tarandus platyrhynchus Vrolik) collected at four different seasons in Svalbard were analysed for their content of Cd, Pb, Cu, Zn, Mn, and Se. The study shows that when animals are exposed to large seasonal variations in both the quality and quantity of food, it is crucial to relate element concentrations to the physiological condition of the animal, e.g., to look at seasonal fluctuations in the total element content of the different organs.

Aging↗
PubMed1995

[Iron status and weaning practices among healthy 1-year old infants].

Iron status and weaning practices were studied in healthy one-year-old Norwegian and immigrant children (from developing countries) attending Fjell Health centre, Drammen. None of the Norwegian children (n = 33) had empty iron stores (serum ferritin < 10 micrograms/l) or iron deficiency anaemia (serum ferritin < 15 micrograms/l and haemoglobin < 11 g/100 ml). Among the immigrant children (n = 37) the prevalences were 14 and 11% respectively. The immigrant children were given infant formula earlier than the Norwegian and drank cow's milk for a longer period of the first year. There were no differences between the groups as regards introduction of infant cereals or other types of foods (vegetables, meat, fish).

Developing Countries↗
PubMed1995

Determination of iron status: brief review of physiological effects on iron measures.

In the last 25 years the repertoire for clinical determination of iron status has been extended with important methods. From blood samples it is now possible to obtain information on the size of the body iron stores and on possible tissue iron deficiency by the levels of serum ferritin and serum transferrin receptor, respectively. These iron measures can be used together to distinguish between iron deficiency anaemia and anaemia from other causes.

Erythrocyte Indices↗
PubMed1995

Associations between serum ferritin and cardiovascular risk factors in healthy young men. A cross sectional study.

OBJECTIVE: This study examines the association between serum ferritin levels and cardiovascular risk factors. DESIGN: The data were obtained from a cross-sectional survey designed to assess the nutrition situation, with special reference to cardiovascular risk factors. SUBJECTS AND SETTING: The study population was 337 healthy men, median age 38 years (range 21-59), working at oil platforms in the North Sea. RESULTS: The associations between serum ferritin, risk factor levels and anthropometric measurements were analysed by age-adjusted partial correlations, step-wise multiple regression, and one-way ANOVA analysis. Body mass index and waist-to-thigh ratio were the strongest predictors for serum ferritin when controlling for age (P < 0.001). In multiple regression analysis, when anthropometric measurements were excluded, fibrinogen, high density lipoprotein (HDL)-cholesterol and diastolic blood pressure were significant predictors for serum ferritin levels when controlling for age (P < 0.001). There was a significant difference in triglyceride concentration between those with low stores of iron and those with high stores (P = 0.006). There were consistently higher levels of total cholesterol, triglycerides, fibrinogen, diastolic and systolic blood pressure, except for HDL where it was reversed, in the highest quartile of serum ferritin levels compared to the lowest. For all the variables the differences between the quartiles of serum ferritin were significant. CONCLUSION: These findings support the hypothesis that the associations between cardiovascular arteriosclerotic disease and serum ferritin are at least partially caused by confounding. SPONSORSHIP: The project was supported by the Norwegian State Oil Company (STATOIL), Amoco Norway Oil Company and Ross Offshore AS.

Adult↗
PubMed1993

[Do we need new guidelines on iron supplementation during pregnancy?].

Studies have shown that the present official Norwegian recommendations on iron supplementation during pregnancy are not followed. A meeting was arranged in February 1993 to discuss the need to change the recommendations. The article describes the conclusions of the panel. It was proposed that the iron status of the pregnant woman, determined as serum ferritin concentration, should be measured early (before the 15th week of gestation) and iron supplement should be given as selective prophylaxis based on the serum ferritin level. The Directorate of Public Health has been asked to issue new recommendations.

Female↗
PubMed1993

[Pregnancy and iron supplementation--are the official guidelines followed?].

In the present study we have examined to what extent the national recommendations concerning iron supplements during pregnancy are being followed. 222 women in childbed were interviewed within one week after delivery concerning their intake of iron and other dietary supplements. We found that no more than 1/4 of the women were using iron supplements according to the national recommendations and that the advice given by doctors, midwives or public health nurses varied considerably. 70% of the women were recommended to take iron supplement, but no more than 66% of them were given specific advice as to which iron preparation they should take, or in what doses. The specific advice that was given varied. 93% of the women who were advised to take iron supplement followed this advice. More women took low-dose iron preparations, while more doctors recommended high-dose preparations. Only 30% of the women thought that iron supplement is vital for all pregnant women. We also found that many of the women (59%) took one or more dietary supplements, alone or in addition to iron.

Female↗