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Biomedical subjects

B Bohus

Publications and source records attributed to B Bohus.

At least 181 records · Page 10Linked to original sources
PubMed1976

Effect of ACTH 4-10 on copulatory bahavior and on the response for socio-sexual motivation in the female rat.

Female copulatory behavior and the urge of a female rat to seek contact with a sexually active male was studied after treatment with the peptide ACTH 4-10. No effects of this peptide were seen on the copulatory response of ovariectomized females treated with estradiol benzoate (EB) alone or EB and progesterone combined. An increasing barrier technique was used to measure how much of an average stimulus (cresssing an electrified grid) a female was willing to endure to gain contact with sexually active male. It has been shown in previous investigations (15) with ovariectomized rats that after a certain time of adaptation and training in this apparatus the response attained remains at a certain basal level from which it is increased by treatment with EB. Animals treated with ACTH 4-10 during the phase of adaptation and training attained a significantly higher basal response level than controls. This effect was only observed when the peptide treatment covered the period of adaptation and was not seen when the treatment was started after this critical period. The EB-induced response was not influenced by ACTH 4-10 given during the period of adaptation or given in connection with the EB treatment. It is concluded that ACTH 4-10 influenced the acquired response level but had no effect on steroid induced responses, which are probably controlled by more innate mechanisms.

Adrenocorticotropic Hormone↗
PubMed1975

Role of noradrenaline and serotonin in the central control of blood pressure in normotensive and spontaneously hypertensive rats.

Noradrenaline and alpha-methylnoradrenaline applied to the area of the nucleus tractus solitarii of the medulla oblongata decreased arterial blood pressure and heart rate of anesthetized normotensive rats. Alpha-Methylnoradrenaline was more effective than noradrenaline. Prior administration of the alpha-adrenergic blocking agent phentolamine at the same site prevented the central inhibitory action of the two catecholamines and even reversed the effect on blood pressure. The hypotensive responses evoked by electrical stimulation or alpha-methylnoradrenaline application were found to have a common distribution of the most effective site, comprising the middle-caudal part of the nucleus tractus solitarii at the obex level. Bilateral electrolytic lesions of this area caused an immediate and severe hypertension. The data suggest that the area of the nucleus tractus solitarii is a site of action of hypotensive drugs which may act by noradrenergic receptor stimulation in the brain. In addition brain serotonin may also play an inhibitory role as indicated by the association of elevated blood pressure and brainstem serotonin depletion during treatment with para-chorophenylalanine of normotensive and genetic hypertensive rats.

Animals↗