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Biomedical subjects

B Bogdanikowa

Publications and source records attributed to B Bogdanikowa.

At least 37 records · Page 2Linked to original sources
PubMed1976

The influence of azathioprine on the behaviour of blood platelets in vitro.

The influence of azathioprine on human platelets was studied in vitro. Azathioprine in a final concentration of 10(-4) M caused significant inhibition of spontaneous sedimentation and aggregation of platelets, but did not effect platelet adhesiveness or resistance to freezing and thawing. The influence of azathioprine is probably due to thioimidazole, this last being a potent stimulating agent of phosphodiesterase activity, involved in the metabolism of cyclic AMP to 5' AMP. These observations indicate that the widely used platelet function assays could be influenced by drugs. The current therapy should therefore be taken into account when the results of the tests are evaluated for clinical purposes.

Azathioprine↗
PubMed1976

The influence of lymphocytes on blood proteins in vitro.

Autologous IgG, IgM and IgA globulins were assayed quantitatively by the immunodiffusion method in cultures of white blood cells from 14 patients with chronic lymphocytic leukemia. In cases in which levels of IgG in the patient's blood were lower than 1,000 mg/100 ml, the IgG globulin was statistically significantly deficient in the cultures. Moreover, concentrations of IgG in the culture supernatant and absolute lymphocytosis were moderately strongly correlated. These observations indicate that the white blood cells of leukemia patients combine with IgG in their environment, and that this may be one of the mechanisms leading to hypogammaglobulinemia.

Agammaglobulinemia↗
PubMed1975

Comparison of results of isolating lymphocytes with Ficoll plus Ronpacon and with gelatin.

White blood cells were isolated from peripheral venous blood with gelatin and with a combination of Ronpacon and Ficoll. Gelatin gave greater concentration of white blood cells, whereas Ronpacon plus Ficoll yielded less concentrated preparations but with significantly higher percentage of lymphocytes, as well as a larger proportion of viable cells in comparison with gelatin.

Blood Cells↗