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Biomedical subjects

B Bigorie

Publications and source records attributed to B Bigorie.

At least 19 recordsLinked to original sources
PubMed1998

Macular dystrophy, diabetes, and deafness associated with a large mitochondrial DNA deletion.

PURPOSE: To report the mitochondrial DNA in a 17-year-old patient with diabetes, deafness, cataract, and maculopathy. METHOD S: Ophthalmologic examination, fluorescein angiography, and electroretinogram were performed. Detection of deletion was analyzed by polymerase chain reaction and Southern blot, and screening for the A3243G mitochondrial DNA mutation was performed. RESULTS: A short fragment of approximately 8.5 kb corresponding to deleted mitochondrial DNA was detected. The A3243G mitochondrial DNA mutation was not found. CONCLUSIONS: A 7-kb heteroplasmic deletion of the mitochondrial genome was found in this patient. No mitochondrial DNA deletion has been reported previously in association with macular dystrophy.

Adolescent↗
PubMed1988

Evaluation of Roche fructosamine test: use for diabetic patient monitoring.

A fructosamine assay using commercially available reagents on an IL Multistat III centrifugal analyser was evaluated. Within- and between-batch precision were less than 4% (CV). Results were similar using serum or oxalated plasma, but were 5% lower than those using sodium heparinate. We compared serum fructosamine and Hb A1c results in insulin-dependent and non-insulin-dependent diabetics: serum fructosamine correlated with Hb A1c (r = 0.80) and gave at least as good a separation of patients from normal controls as did Hb A1c.

Adult↗
PubMed1981

Estradiol, progesterone and plasma lipids during the menstrual cycle.

Epidemiological data tend to relate some of the sex differences in plasma lipid levels to the physiological secretion of estrogens and progesterone. The influence of sex hormones on plasma lipoprotein metabolism has not been extensively investigated. Precise correlation between plasma lipids and circulating hormones levels are still lacking. The short term effect on plasma lipids of large variations in estradiol and progesterone plasma levels occurring during the menstrual cycle has been studied in eight fertile women over a total of 18 cycles. Concentrations of plasma lipids, particularly triglycerides and HDL cholesterol levels were remarkably stable in the three hormonal situations studied, namely during menstruation (low estradiol and progesterone levels), in the follicular phase of the cycle (high estradiol and low progesterone levels) and in the luteal phase (high estradiol and progesterone levels). Considerable variation of plasma estradiol levels (400%) did not modify, the plasma lipid values on a short term basis (8-21 days). The physiological role of 17-beta estradiol and progesterone in the sex differences of blood lipid levels remains to be clarified. If this metabolic effect exists, it does not seen to be influenced by short term variation in hormone levels.

Adult↗
PubMed1975

[Is triacetyl oleandomycin-ergotamine tartrate combination dangerous?].

The authors report a case of ischaemia of all four limbs in an adolescent following the simultaneous ingestion of triacetyl oleandomycin and ergotamine tartrate in low dosage. Two cases involving this same association of medications have appeared in the literature and attention is therefore drawn to the possible danger of use of these two drugs together.

Adolescent↗