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Biomedical subjects

B Berkowitz

Publications and source records attributed to B Berkowitz.

34 records · Page 2Linked to original sources
PubMed1977

The effect of guanethidine and hydrochlorothiazide on blood pressure and vascular tyrosine hydroxylase activity in the spontaneously hypertensive rat.

The present study examined the effects of antihypertensive drugs (hydrochlorothiazide and guanethidine) on blood pressure and tyrosine hydroxylase (TH) activity in the spontaneously hypertensive rat (SHR). Hydrochlorothiazide (50 mg/kg X 4 days) lowered blood pressure in the SHR to a degree equivalent to that produced by reserpine (0.3 mg/kg X 3 days). However, while reserpine increased vascular and adrenal TH activity, hydrochlorothiazide had no effect. Guanethidine (30 mg/kg X 2 days) reduced blood pressure in the SHR and also depleted cardiac, vascular and adrenal gland catecholamines; However, guanethidine administration did not increase TH activity in the mesenteric vasculature or adrenal glands. These studies indicate that at equieffective blood pressure lowering doses, different antihypertensive drugs have different effects on TH activity in the SHR. Neither blood pressure reduction nor catecholamine depletion in peripheral tissues are sufficient prerequisties for increasing TH activity. The data support the suggestion, however, that amine depletion in the central nervous system or ganglia may be an important factor in the regulation of TH.

Adrenal Glands↗
PubMed1972

Evidence for active immunity to morphine in mice.

The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.

Analgesia↗
PubMedDate not supplied

The Community Tool Box: a Web-based resource for building healthier communities.

Building healthier cities and communities requires an array of community-building skills that are not always taught in formal education. The Community Tool Box (http://ctb.ukans.edu) is an Internet-based resource for practical, comprehensive, accessible, and user-friendly information on community-building, which both professionals and ordinary citizens can use in everyday practice. It connects people, ideas, and resources, offering more than 200 how-to sections and more than 5,000 pages of text.

Community Health Planning↗
PubMedDate not supplied

Application of continuous time random walk theory to tracer test measurements in fractured and heterogeneous porous media.

We examine a set of analytical solutions based on the continuous time random walk (CTRW) approach, which can be evaluated numerically and used to analyze breakthrough data from tracer tests. Practical application of these solutions, with discussion of the physical meaning of the relevant model parameters, is emphasized. The CTRW theory accounts for the often observed non-Fickian (or scale-dependent) dispersion behavior that cannot be properly quantified by using the advection-dispersion equation. The solutions given here, valid for a wide range of dispersive behaviors of conservative tracers, and useful for both characterization and prediction, have been integrated into a library of external functions for use with the GRACE graphical display and analysis package. Example applications of these solutions are presented. The library and graphics software are freely accessible from a Web site.

Chemical Phenomena↗