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Biomedical subjects

B Berger

Publications and source records attributed to B Berger.

At least 181 records · Page 10Linked to original sources
PubMed1976

Patch graft urethroplasty for urethral stricture disease.

The results with 34 cases of patch graft urethroplasties for urethral stricture disease were compared to the results in other series and found to be significantly worse. Various factors that might have influenced the surgical results were analyzed. Patients dilated least frequently had the best results.

Dilatation↗
PubMed1976

[Neurological manifestations in monoclonal gammapathies. Pure neurological manifestations. Immunofluorescence study].

Analysis of 105 peripheral and central nervous system complications in 1062 monoclonal gammapathies draws attention to two types of phenomena. The possibility of pure neurological manifestations of IgM monoclonal gammapathies with macroglobulinorachia leads to discussion of their nosological position in relation to Waldenström's disease, Burkitt's lymphoma and Marek's disease. It is suggested that these cases should be reclassified under the heading "secreting neurolymphomatosis". Immunofluorescence and electron microscopy of 10 biopsies of the peripheral nerve showed deposits of monoclonal immunoglobulin whose function in determining peripheral neuropathies is discussed. The simultaneous presence of lymphoid infiltration, amyloid deposits and the monoclonal immunoglobulin (M component) suggests that this immunoglobulin could be the link between the cellular infiltrate secreting it and amyloid infiltration which would be the visible manifestation of it.

Amyotrophic Lateral Sclerosis↗
PubMed1976

[Catecholaminergic axons in the human cerebral cortex. Observation by histofluorescence of cerebral biopsies in 2 cases of Alzheimer's disease].

Catecholamine axons have been visualized in human cerebral cortex obtained during routine neurosurgical operations. The fluorescence histochemical method of Lindvall et al. was used, slightly modified (calcium-deprived buffer, glyoxylic acid fixation followed by formaldehyde vapours exposition). The frontal cortex was more richely provided with catecholamine terminals than the parietal cortex. Two general types of axon morphology are evident. The most frequent is thin and sinous, sometimes forming clews, or loose basket-like arrangement around presumed nerve cells. The other one is moniliform and demonstrates spherical evenly-spaced varicosities. They look like, respectively, the well characterized dopaminergic and noradrenergic axons of the rat cerebral cortex. In two cases of Alzheimer's disease, noradrenergic-like fibers were missing and voluminous green-fluorescent varicosities, sometimes in obvious connection with typical axons, were observed in the proximity of senile plaques.

Alzheimer Disease↗
PubMed1975

Ultrastructural observations on human cerebral capillaries in organ culture.

The use of an organotypic-in the strictly literal meaning of the word, nervous tissue culture device has allowed the identification and ultrastructural study of various types of developing capillaries in human cerebellum and olfactory bulb in vitro. Most capillaries were similar to those already described by other authors or by us, in human or animal embryos and fetuses. Large Type I Capillaries. Their luminal diameters were greater than 8 microns. The basement membranes were thin and discontinous. Numerous interendothelial junctions were either plate-like attachments or contained pentalaminar zones. Type II Capillaries. Their lumina were between 2 and 8 microns in diameter. The basement membranes were wider than those of type I capillaries and were sometimes continuous. The interendothelial junctional complexes of type II capillaries included pentalaminar portions. Many simple or complex vascular sprouts (type IV and V capillaries) had small or non-patent lumina. Their basement membranes were absent or very thin and discontinuous. Their interendothelial junctions were similar to those of type I capillaries. Some of the less frequently encountered capillary types seen in developing human nervous tissue were absent in culture. Some pathological features were seen-especially in long-term cultures-in type I and II capillaries containing degenerating blood cells or processes sometimes obviously related to histiocytic cells. They consisted mainly of an accumulation of microfilaments and modifications of the rough endoplasmic reticulum in the endothelial cells. These pathological changes did not modify the main characteristics of the capillaries. The origin of the vascular sprouts, the exact nature of the interendothelial junctions and the significance of the pathological changes are discussed. This model may prove useful for the study of cerebral vasculogenesis, the development of the blood-brain barrier and the physiological or pathological properties of the human brain capillaries in tissue culture.

Basement Membrane↗
PubMed1975

Electron microscopic study of the developing capillaries of human brain.

The ulstrastructural characteristics of the cerebellum and olfactory bulb capillaries were studied in 12 human specimen measuring 25-200 mm. Type I capillaries, whose lumina were wider than 8 mu, contained no pores of fenestrations. The basement membrane was sometimes discontinous. In that case, junctions without quintuple-layered zones could be observed. Such capillaries may correspond to primary vessels in which the sinusoid character has disappeared. Elsewhere, the basement membrane was continuous and the interendothelial junctions always contained quintuple-layered zones. Type II capillaries, whose lumina measured between 2 and 8 mu had basement membranes that were either discontinuous or continuous. They were identical to the immature capillaries described previously in numerous species including man. Type III caillaries, rarely observed, were characterized by the presence of several endothelial cells with abundant cytoplasm, which limited the mina from 0.5 --3 mu in diameters. They had continuous basement membranes. Type IV and V capillaries has small or non-patent lumina. The basement membrane was absent or rudimentary. These capillaries appeared to correspond to simple and complexendothelial sprouts. In Types II, III, V and most Type IV capillaries, the interendothelial junctions contained quintuple-layered zones. No mature capillaries were observed. The hypothetical pathways of development of cerebral capillaries and the degree of permeability of immature interendothelial junctions are discussed. The long duration of maturation in man probably accounts for the diversity of capillary formations observed as compared with animals. The co-existence over along period of time of several capillary types with probably varying permeability may play a significant role in the maturation of the blood-brain barrier.

Basement Membrane↗
PubMed1975

Values clarification and the cardiac patient.

This exploratory study tested the feasibility and potential of values-clarification methods in patient education with 20 chronic heart patients participating in the cardiac classes of a university medical center. Strengths and limitations of the methods were identified, with greater feasibility and responsiveness demonstrated in patients between 51 and 60 years of age, those who had accepted their cardiac problem, and in home visits rather than clinical settings.

Adult↗
PubMed1975

Concepts and limitations in the application of radiolabeled antiandrogens, estrogens, or androgens as isotopic scanning agents for the prostate.

The distribution of labeled antiandrogens, estrogens, and androgens has been studied in the rat and dog to elucidate the principles and limitations encountered when these agents are used in radioscanning the prostate. The bulk of the label is rapidly cleared in the biliary secretions and in the urine. The concentration of label in the prostate in comparison to other tissues such as the intestines limits the application of these agents in radioscanning of the prostate. The tissue distributions were confirmed by total body radioscans of rats and dogs receiving a labeled 3'-iodinated analog of the antiandrogen flutamide (Sch 13521 or 3'-trifluoromethyl-4'-nitroisobutyranilide).

Anilides↗