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Biomedical subjects

B Berg

Publications and source records attributed to B Berg.

At least 73 records · Page 4Linked to original sources
PubMed1983

Failure of exogenous secretin to induce secretion of calcitonin in man.

The effect of secretin on calcitonin secretion from the human thyroid gland was studied in 15 patients undergoing thyroid and parathyroid surgery. Secretin was administered into the inferior thyroid artery at two different doses (0.75 and 7.5 CU) and into a peripheral vein at a dose of 75 CU. Blood samples for measurements of calcitonin and calcium were collected from thyroid or peripheral veins. However, neither intraarterially nor iv administered secretin was able to evoke any significant calcitonin response as measured in thyroid or peripheral venous blood. The calcium level was unaffected by secretin. The results demonstrate that secretin does not act as a calcitonin secretagogue in man.

Adult↗
PubMed1983

Plasma estriol in late pregnancy in relation to fetal outcome.

The study is a retrospective report on the capacity of plasma (P-) estriol (E3) determinations in late pregnancy to detect abnormal fetoplacental state at delivery. From the material of cases with P-E3-determinations, two extreme groups were chosen for comparison: those with absolutely normal fetoplacental status at parturition and those with severe disturbances of the fetoplacental status at delivery. The predictability of a single P-E3 value was generally low, especially at the end of pregnancy. Consecutive (at least 3) high or low values, respectively, in the individual case, proved to have a predictable value that might complement other clinical methods for assessing fetoplacental function.

Apgar Score↗
PubMed1982

Correlation between relative responses in mixed lymphocyte culture, HLA-D and DR typing, and graft survival in renal transplantation.

The impact of renal graft survival of a low relative response (RR) in mixed lymphocyte culture (MLC) and HLA-D/DR compatibility was analyzed. Ninety-five recipients and donors of cadaver kidneys and 58 intrafamilial, HLA-haploidentical, recipient-donor pairs in a Stockholm series constituted the case material. The gene frequencies of and the correlation coefficients between the HLA-D/DR assignments were calculated from an extended material of about 400 individuals, all recipients or donors of renal grafts in Stockholm. Close correlation between the D and DR assignments existed. The combined gene frequencies of the detected D/DR antigens were 0.67 and 0.08. The RR values in the MLC tests were widely scattered, but lower medians were found in the better D/DR-matched groups. The 1-year survival of cadaveric grafts was 69% when the RR values in the MLC between recipient and donor were below 55 and 49% when the RR values were above 55%. The difference was statistically significant (P less than 0.05). Also, significantly higher graft survival rates were obtained in transplants groups where the recipient and donors were well matched for the D and DR antigens. In the transplant groups where no D/DR incompatibility existed, the 1-year graft survival was 93 and 89%, respectively, when the RR values in the MLC tests between recipients and donors were below 55%. We concluded that a close correlation existed between cellular and serological HLA-DS typing. A beneficial effect was noted on graft survival of matching for these antigens.

Cadaver↗
PubMed1982

Cerebrospinal fluid lactate in the diagnosis of meningitis. Diagnostic value compared to standard biochemical methods.

Cerebrospinal fluid (CSF) lactate was determined in 245 patients by means of a rapid enzymatic method (Monotest Lactate). The mean value was 1.61 mmol/l (range 0.79-3.33) in 104 control patients, 2.06 mmol/l (range 0.76-4.31) in 121 patients with aseptic meningitis, and 8.18 mmol/l (range 1.77-19.21) in 20 patients with bacterial meningitis. In most of the patients CSF protein and the CSF/blood glucose quotient were also determined. Lactate and glucose quotient differentiated equally well between aseptic and bacterial meningitis while protein was somewhat less useful. Suitable values for discrimination between aseptic and bacterial meningitis were judged to be 3.0 mmol/l for CSF lactate, 1.0 g/l for CSF protein and 0.5 for the glucose quotient. Combinations of tests improved the diagnostic accuracy in aseptic but not in bacterial meningitis. In 2 patients with bacterial meningitis all tests failed. CSF lactate may be used as a supplementary aid in the diagnosis of meningitis. Its diagnostic efficacy was equal to but not better than that of the traditional methods.

Adolescent↗
PubMed1981

The influence of HLA-A, B compatibility on the outcome of cadaver renal transplantation in Stockholm during 1970-1980.

The influence of HLA-A, B-matching on the results of 362 cadaver renal transplantations was analyzed. Of these, 34 of the patients had diabetes and 105 were 55 years old or more. The case material was divided into groups, based on the number of HLA-A, B incompatibilities. The occurrence of factors having a possible bearing on kidney graft survival was determined in each match group. It was found that several of these factors, such as the immunosuppressive agents given and the number of high-risk patients, were unequally distributed in the various groups. This may be related to changes in policy that have occurred since the transplant unit was moved to Huddinge Hospital in November 1973. In order to obtain homogeneous case material, the Huddinge series was analyzed separately. A significant difference in survival was found in both materials between transplants with 2 or less incompatibilities and those with more than 2 incompatibilities. A significant difference in patient survival between these two groups was found in the total case material.

Blood Transfusion↗
PubMed1981

The influence of HLA-DR match on the outcome of cadaver renal transplantation in Stockholm during 1977-1980.

The influence of HLA-DR match grade on graft and on patient survival was analyzed in 124 recipients of cadaver kidneys who were treated in Stockholm between January 1977 and September 1980. The material consisted of 72 males and 52 females, with a mean age of 49 years. There were 34 re-transplantations. Eighteen of the recipients had diabetes. Sera against the HLA-DR antigens 1-4, 7 and DRw8 were available throughout. During recent years, DR5 sera were also used. The case material was analyzed as to the number of DR antigens shared or to the number of DR incompatibilities between the donor and the recipient. A significant improvement in graft survival rate was found for transplants sharing one HLA-DR antigen as compared with those sharing none. As far as incompatibilities are concerned, a significant difference was found between transplants with no incompatibilities and those with two. The HLA-A, B incompatibilities were evenly distributed throughout the various groups and thus should not have introduced a bias in the interpretation of the influence of HLA-DR match. We conclude that HLA-DR matching has a very beneficial effect on the graft survival rate and we shall in future try to obtain the best possible match when selecting recipients for cadaver kidney transplantation.

Adult↗
PubMed1981

Stability of serum and blood constituents during mail transport.

We have studied the stability of 14 serum and blood constituents after 4 days transport by mail at ambient temperature. For statistical evaluation a graphical truncated normal sequential test was used. A constituent was considered stable when the change of the mean concentration of the constituent was less than an amount equal to one standard deviation of the analytical method used, with 5% risk of error for the decision. Under these conditions 9 constituents were stable: serum albumin, creatinine, sodium, potassium, calcium, alkaline phosphatase, gamma-glutamyltransferase, blood haemoglobin and blood erythrocytes. Instability was found for serum bilirubin, blood leucocytes, haematocrit and erythrocyte volume related variables. The experimental design allows stability data to be collected during field testing by using daily runs in the laboratory. Data of this kind are essential for making a reliable laboratory service available to primary care units. The demands of the clinical situation should, however, be taken into consideration.

Blood Chemical Analysis↗
PubMed1981

Further experience with antihuman lymphocyte globulin (Behring): no effect on cadaveric renal graft survival.

In 1977 we reported that 1 year cadaveric renal graft survival was improved in patients treated with high dose anti-human lymphocyte globulin (AHLG) (Behring). Such a beneficial effect of this agent was not confirmed in the present study with an enlarged series of patients and with a longer follow-up time. Nor was there any gain in respect of renal function or any steroid sparing effect. The only indication of an immunosuppressive effect is that the rejection episodes possibly occurred later in the patients given the high dose AHLG.

Antilymphocyte Serum↗
PubMed1981

The influence of HLA-D matching on the outcome of intrafamilial kidney transplantation with special emphasis on the predictive value of the relative response in MLC.

One hundred and three recipients of kidney transplants from living related donors were analyzed for the influence of HLA-D matching on graft survival. Sixty-two donors were parents and 41 brothers or sisters. Twenty-two of the siblings were HLA-A, B identical. The degree of HLA-D compatibility was measured in a mixed lymphocyte culture reaction. Whereas nonresponsiveness was found with HLA-A, B identical sibling donors, the haploidentical donors were found to initiate varying degrees of stimulation. The stimulation was, calculated as the relative response (RR) to the donor in relation to an unrelated individual or to lymphocytes pooled from a number of individuals. It was found that RR values above 55% predicted a graft survival that was significantly inferior to the group with values less than 20% (p less than 0.01) and also to the group with RR values between 20% and 55% (p less than 0.05).

Actuarial Analysis↗
PubMed1981

Use of rabbit anti-human thymocyte globulin in cadaver kidney transplantation. Preliminary experiences.

Rabbit anti-human thymocyte globulin was given as an adjunctive immunosuppressive agent to 23 recipients of cadaver kidneys in the immediate 14 day post-transplantation period. A drastic reduction in the number of T-lymphocytes in the peripheral blood was recorded and there was a very low frequency (13%) of early, acute rejection episodes. Two to 8 months after transplantation 13 of 14 patients (93%) below 55 years of age survive with a functioning graft. Among 9 older recipients, the patient and graft survival was 56 and 33% and 4 of the patients died with septic complications. It is concluded that the elderly patients were over-immunosuppressed and we will no longer use RATG in this patient category.

Anaphylaxis↗
PubMed1981

The influence of HLA-DR match on cadaveric renal graft survival. Experience from Stockholm.

The influence of HLA-DR match on graft and patient survival was analyzed in 124 cadaveric kidney transplant recipients treated between January 1977 and September 1980. The material consisted of 90 primary transplant and 34 retransplants. The mean patient age was 49 years, 72 were males and 52 females. Eighteen of the recipients were diabetics. Sera against the HLA-DR antigens 1-5, 7 and DRw8 were available, for DRS only during the later half of the period. When the case material was divided according to the number of donor-recipient HLA-DR antigens shared, a significant improvement in graft survival was found if one antigen was shared as compared to none shared. When 2 antigens were shared graft survival was excellent but there were only 7 such cases. When division was performed according to the number of existing HLA-DR incompatibilities, a significant improvement in graft survival was noted when there were no incompatibilities as compared with 2 incompatibilities. The distribution of foreign HLA-A, B antigens was even between the DR match groups and did therefore not constitute a bias. We conclude that matching for the HLA-DR antigens has a major beneficial effect on cadaveric kidney graft survival.

Actuarial Analysis↗