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Biomedical subjects

B Benjamin

Publications and source records attributed to B Benjamin.

At least 19 recordsLinked to original sources
PubMed1992

Childhood brucellosis in southwestern Saudi Arabia: a 5-year experience.

One-hundred-and-fifty-seven children admitted with brucellosis at Abha, Saudi Arabia, were studied prospectively. Ninety-two per cent gave a history of animal contact, usually with sheep or goats, or ingesting raw milk, milk products, or raw liver. Three-quarters of the patients had an acute or subacute presentation with diverse symptomatology: fever (100 per cent), malaise (91 per cent), anorexia (68 per cent), cough (20 per cent), abdominal symptoms (20 per cent), arthralgia (25 per cent). Hepatomegaly (31 per cent), splenomegaly (55 per cent), and lymphadenopathy (18 per cent) were common findings. Organ complications were rare except for arthritis (36 per cent) which usually presented as a peripheral oligoarthritis involving the hips and knees. All patients had significant agglutination titres; B. melitensis was grown from the blood in 7 of 16 (44 per cent) patients. Haematological variations were common, but non-specific: anaemia (64 per cent), thrombocytopenia (28 per cent), leucopenia (38 per cent), leucocytosis (12 per cent), and elevated erythrocyte sedimentation rate (81 per cent). Varying combinations of rifampicin, co-trimoxazole, tetracycline, and streptomycin resulted in a prompt pyrexial response (mean: 3.8 days), and a slower response in the arthropathy and hepatosplenomegaly. Relapses were related to poor compliance, use of a single drug or a shorter duration of chemotherapy. Brucellosis is a common childhood problem in southwestern Saudi Arabia as in other parts of the country and the Middle East. It should be considered in every child from an endemic area presenting with a febrile illness and a history of animal contact.

Agglutination Tests↗
PubMed1992

Bronchoscopy in lipoid pneumonia.

Forcible administration of rendered animal fat to infants is a tradition in south western Saudi Arabia. Accidental inhalation may result in a resistant form of lipoid pneumonia. A series of 24 cases of lipoid pneumonia, 22 of which were diagnosed by bronchoscopy with bronchial lavage and microscopic examination of the aspirate, are reported. The technique is described briefly and the results analysed. A high index of suspicion together with bronchoscopy and bronchial lavage of all cases of resistant or recurrent pneumonia is essential in areas such as ours for diagnosis of this condition.

Bronchoscopy↗
PubMed1991

Congenital interarytenoid web.

Congenital interarytenoid web is a rare laryngeal anomaly whose distinctive feature is a band of tissue joining the medial surfaces of the arytenoids and restricting abduction of the vocal cords. It appears to arise from persistence of the embryonic membranous interarytenoid layers, which form the epithelial lamina of the fetal laryngeal sagittal cleft. This review of 16 cases seen in a 15-year period describes the clinical features, diagnostic evaluation, and management. In addition to the interarytenoid web, which is present to some degree in all patients, associated anomalous features may include subglottic stenosis, enlarged bulky arytenoids, and difficulty exposing the larynx and maintaining the airway during anesthesia and endoscopy. The association of these four features in this rare laryngeal anomaly has not been previously described. Diagnosis depends on direct laryngoscopy with particular attention to the posterior larynx. Tracheotomy may be required for 3 to 5 years as definitive corrective management has not been established.

Female↗
PubMed1991

Diagnosis of H-type tracheoesophageal fistula.

A study was made of the diagnostic aspects of 11 cases of congenital tracheoesophageal fistula without atresia (H-fistula) seen in the 17 years 1971 through 1988. The features of aspiration with feeding were present from birth in all cases, and yet the diagnosis was often delayed. The results emphasise the complimentary diagnostic roles of contrast esophagogram and rigid open-tube endoscopy. The latter not only yields a high diagnostic rate but is necessary for evaluation of associated congenital anomalies of the aerodigestive tract.

Esophagoscopy↗
PubMed1991

Management of airway obstruction in the Pierre Robin sequence.

A 10-year retrospective study of the management of airway obstruction in 26 infants with Pierre Robin sequence was made. It was not possible when the infant was first seen to assess the future severity of the airway obstruction but later 3 distinct groups could be identified according to the airway management which had become necessary. The deaths from respiratory obstruction indicate the prime importance of airway management. Laryngoscopy for intubation or endoscopic evaluation was often difficult and sometimes could not be achieved. 'Awake intubation' without general anesthesia has proved to be safer and less difficult using a special purpose slotted laryngoscope. Airway management should be individualized following the progressive sequence of posturing in the prone position, nasopharyngeal tube, endotracheal intubation and tracheotomy until successful control is achieved as indicated by the clinical features and pulse oximetry.

Airway Obstruction↗
PubMed1991

Lipoid pneumonia in children following aspiration of animal fat (ghee).

Exogenous lipoid pneumonia induced by modified animal fat (ghee) in 10 children is described. The initial presentation was of an acute or chronic pneumonia which proved refractory to anti-microbial chemotherapy. The radiological presentation varied from mild perihilar consolidation to diffuse and extensive bilateral involvement, particularly of the posterior lung segments. A history of administration of ghee provided the initial clue to the diagnosis, which was confirmed by demonstration of fat by bronchoalveolar lavage or by open lung biopsy. Eight of the 10 patients improved with either steroid therapy alone or steroids with resection of the most involved lung segments. One patient, who had extensive superinfection with Mycobacterium fortuitum, died. Lipoid pneumonia should be considered in the differential diagnosis of 'non-resolving' pneumonias in communities where the cultural practice of infant feeding with ghee is prevalent. Public awareness through health education about the potential hazards of this practice to infants and children can contribute to reduce the incidence of the problem.

Animals↗
PubMed1991

Laser treatment of pharyngeal pouch.

The symptoms of pharyngeal pouch become more troublesome, eventually requiring surgical treatment. Excision of the pouch and cricopharyngeal myotomy through a neck incision was the operation of choice until Dohlman described endoscopic diathermy operative treatment 30 years ago. The diathermy technique has been largely superseded by endoscopic microsurgical division of the cricopharyngeus muscle in the party wall using carbon dioxide laser. This operation is now established as a precise, accurate and safe procedure providing reliable relief of symptoms with minimal risk to the patient. Fifteen patients treated by the microsurgical laser procedure in the past 5 years are reported.

Aged↗
PubMed1991

Acute epiglottitis.

Acute epiglottitis, a fulminating infection in the supraglottic tissue due to Haemophilus influenzae type B can cause relentlessly progressive airway obstruction in infants, children and sometimes in adults. Rapid infection and swelling of the epiglottis and aryepiglottic folds causes airway obstruction which can be relieved by endotracheal intubation. The systemic infection and septicaemia must be treated by the appropriate intravenous antibiotics. Acute epiglottitis must be differentiated from viral laryngotracheitis or "croup" which is very common and from pseudo-membranous bacterial tracheitis which is rare. A protocol for management of acute inflammatory airway obstruction must involve an orderly sequence of diagnostic and therapeutic measures, instituted without delay.

Acute Disease↗
PubMed1991

Review of intubation in severe laryngotracheobronchitis.

Of 208 children who required relief of severe airway obstruction due to laryngotracheobronchitis by an artificial airway (nasotracheal intubation or tracheostomy) during a 10-year-period, 181 (87%) were intubated and later extubated. Twenty-seven children (13%) had tracheostomies performed. The tracheostomies were for severe subglottic narrowing precluding the passage of an adequate size endotracheal tube in 10 children, and for severe endotracheal tube trauma in 17 children. Five children developed acquired subglottic stenosis (2.4% of 208) and 1 of these has a retained tracheostomy. One child died of cardiac disease. The remaining 202 children had no long-term complications of laryngotracheobronchitis, intubation, or tracheostomy. It is concluded that nasotracheal intubation is a satisfactory artificial airway for laryngotracheobronchitis. Endoscopic evaluation in a selected group of these children will identify those with significant intubation trauma or severe subglottic narrowing in whom continued intubation may cause permanent subglottic damage. The low incidence of acquired subglottic stenosis in this series supports the practice of selective endoscopy and tracheostomy.

Airway Obstruction↗
PubMed1990

Infant tracheotomy--endoscopy and decannulation.

The records of 73 infants aged 24 months or less who underwent tracheotomy in a 10-year period were reviewed. Two common problems before decannulation were granulations and suprastomal collapse of the anterior tracheal wall above the internal stoma. There were no decannulation failures which could not be accounted for by the primary airway problem. There was no evidence of unexplained "dependence" on the tracheotomy. The results confirm that tracheotomy in the infant patient can be safe both short-term and long-term. There has been no similar long-term review of tracheotomy in small infants indicating the place of endoscopy and the technique of decannulation.

Australia↗
PubMed1990

Alcohol use and limitations in physical functioning in a sample of the Los Angeles general population.

The authors examined the relationships between drinking and perceived current health and physical functioning for a general household sample of Mexican Americans and non-Hispanic whites. These relationships differed by sex and by the presence or absence of medical and psychiatric comorbidity, but not by ethnicity. Among men with a chronic medical illness, current abstinence was uniquely associated with poor current health and physical functioning, especially when current abstinence was combined with a past history of alcohol disorder. Among men without a chronic medical illness, a history of alcohol disorder (irrespective of current drinking) was uniquely associated with poorer functioning. For women, among the medically or psychiatrically ill, drinking was not strongly associated with physical functioning; while among women without chronic medical or psychiatric illness, a history of drinking was uniquely associated with poor physical functioning. The authors interpret the findings in terms of adverse effects of drinking and chronic medical conditions on functioning and the tendency of physically limited and chronically medically ill persons to stop drinking.

Activities of Daily Living↗
PubMed1990

Patient, provider and hospital characteristics associated with inappropriate hospitalization.

To determine the relation between patient and provider characteristics and inappropriate hospital use, we examined adult nonpregnancy hospitalizations from a randomized trial of health insurance conducted in six sites in the United States. Appropriateness of inpatient treatment was based on medical record review; patient characteristics on sociodemographic, economic, and health status; and provider characteristics on descriptors of physician practice and hospital facilities. Twenty-seven percent of admissions attended by physicians licensed for more than 15 years were judged inappropriate, compared to 20 percent for younger physicians. Admissions were more likely to be inappropriate if the patient was female (27 percent compared with 18 percent). Controlling for patient and provider characteristics reduces but does not eliminate the differences in the appropriateness of inpatient care across the study's six sites. Differences in available provider and patient characteristics do not account for geographic differences in inappropriate hospitalization in this study.

Cost Control↗
PubMed1989

Gastric heterotopia causing airway obstruction.

Two infants are reported each with a mass of heterotopic gastric tissue in the hypopharynx causing airway obstruction. Endoscopic laser removal of the tumours proved a satisfactory method of treatment. Gastric heterotopia in the head and neck region is rare but should be considered as a cause of stridor in infants.

Airway Obstruction↗
PubMed1989

T-cell abnormalities in antibody deficiency syndromes.

We studied two patients with hypogammaglobulinaemia, three with selective IgA deficiency, and four with selective extreme IgM deficiency for T-cell abnormalities in the circulating blood. Most patients had altered CD4+ helper/inducer and CD8+ suppressor/cytotoxic T-cell subsets, and an elevated percentage of HLA-DR+ and interleukin 2 (IL-2) receptor+ antigens on lymphocytes. One patient with the selective IgA deficiency had an absence of CD4+ T cells in blood. The lymphocytes of eight patients showed a diminished proliferative response and deficient IL-2 production in response to stimulation with phytohaemagglutinin or concanavalin A. The three patients with selective IgM deficiency were found to have a defective T-cell abnormality in IgM synthesis by B cells. It is interesting that CD8+ T cells of the two patients with IgM deficiency demonstrated suppressor cell function for IgM synthesis by the normal B and T cells.

Agammaglobulinemia↗
PubMed1989

Minor congenital laryngeal clefts: diagnosis and classification.

Cleft larynx is a rare congenital anomaly. Detection of an unsuspected minor cleft may be difficult, but the pediatric laryngologist should suspect the possibility of cleft larynx from the clinical features. Four minor clefts are reported, three cases of supraglottic interarytenoid cleft and one of partial cricoid cleft. The technique for endoscopic diagnosis and the distinctive features are described and a classification into four types is proposed.

Abnormalities, Multiple↗