It has been possible to extract a suppressor factor specific for antigen from non-responder animals that have developed suppressor cells. This factor shows a high affinity for the antigen and cross-reacts with related antigens. It does not carry antigenic determinants of the constant region of immunoglobulin molecules but carries Ia determinants and has an affinity for the GAT comparable to the affinity of the anti-GAT antibodies.

Animals↗

PubMedDate not supplied

Genetic control of specific immune responses.

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Animals↗

PubMedDate not supplied

Jarcho-Levin syndrome: prenatal diagnosis, perinatal care, and follow-up of siblings.

Jarcho-Levin syndrome (JLS), spondylothoracic or spondylocostal dysostosis, is a rare entity with variable clinical severity. This syndrome is usually diagnosed in individuals with short neck, short trunk, and short stature with multiple vertebral anomalies at all levels of the vertebral column, including "butterfly vertebrae," hemivertebrae, and fused, hypoplastic vertebrae. The small size of the thorax in newborns frequently leads to respiratory compromise and death in infancy. We report a family in which the diagnosis of JLS in a 1-year-old led to prenatal ultrasound diagnosis of JLS in a sibling. Aggressive neonatal care of the sibling, who developed respiratory failure soon after birth, led to an excellent outcome. This case confirms the utility of the prenatal ultrasound diagnosis of JLS and suggests that when the diagnosis of JLS is known prenatally, appropriate preparations can be made for specialized prenatal and postnatal care that may improve survival.

Abnormalities, Multiple↗