[Radionuclide study of thyroid function in pediatrics, using 99mTc, 123I or 131I: 150 case-reports (author's transl)].
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Biomedical subjects
Publications and source records attributed to B Basse-Cathalinat.
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An isotopic method employing microspheres of serum-albumin of a mean diameter of 15 microns was used to study the problem raised by the development of arteriovenous fistulae following saphenous by-pass in situ, enabling measurement of shunt flow and qualitative evaluation of the distal bed. Shunt blood flow varies greatly from practically negligible quantities to a maximum of 90%. Comparing data from angiography during operation with these data showed a parallel between the worst angiographic appearances, the poorest scintigraphy images, and the most marked shunts. Sustained clinical manifestations of the fistulae were apparent in shunts of over 60% only. Signs of ischaemia were absent, even in shunts taking 90% of by-pass blood flow. Arteriovenous fistulae induced by by-pass operations employing the saphenous vein in situ appear, therefore, to be relatively well-tolerated. Ligature of the most important, preferably proximal, collaterals is nevertheless recommended, to reduce disturbing side-effects as far as possible, and loss of flow to the distal arterial bed in cases with very large fistulae.
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A new radioisotopic method for the evaluation of the healing potential of a fracture is developed in this paper. The centromedullary circulation in the bone is visualized under general anaesthesia by means of pertechnetate 99TcmO4 injected into the distal metaphysis of the tibia. Twenty-two patients with an average age of 25 years have had this examination. All suffered from a fracture of the leg with a worrying evolution. Isotopic osteomedullography has shown that the resumption of centromedullary circulation was the most favourable factor for good healing of the fracture. When the examination is positive, it seems advisable to wait until the focus is healed even if the clinical and/or radiographic survey are not in accordance, but when there is no resumption of the centromedullary circulation a pseudoarthrosis may well result. As the reliability of this technique is satisfactory, it should be used when doubt remains about healing of a fracture.
The authors present a work intended to assess the effects of lumbar sympathectomy using radioactive microspheres. These contain 99mTe and are injected into the femoral artery. The distribution of radioactivity is then measured at the lower limb with a gamma camera linked to a computer. Seventeen patients were tested before and after lumbar sympathectomy. It appears from this short series that lumbar sympathectomy causes a redistribution of the radioactive material directed towards the extremities, mainly the feet.
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Biological data concerning 249 thyroid patients have been treated by using correspondance factor analysis. This statistical treatment has enabled us to compare 2 types of associated tests (in vitro, in vivo) and to evaluate their respective contribution to the diagnosis of different thyroid diseases. There appeared also certain possibilities for the use of such a method in the future: determination of a biological profile for thyroid disease and for Grave's disease patients in course of treatment.
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Effects of magnetization transfer were evaluated in vitro on circulating blood. Various velocities were tested from 0 to 72 cm/second. Decrease signal intensity caused by magnetization transfer effects was inversely proportional to inflow velocity. It reached 10% at very low velocities and disappeared at velocities higher than 30 cm/second.
To evaluate whether dissolved calcium from tricalcium phosphate implants contributes to osseous wound healing in bone defects, the authors used nuclear radioactivated materials. Six months after irradiation, the calcium was still radioactive. Samples of the material were prepared and placed in rabbit condyles for 1, 3 and 9 months. Over time the condyles were retrieved and treated for histology or radiocounting. Measurements of the radioactivity of the slices and histomorphometry of the implants and surrounding tissues were performed. The authors observed that the radioactivity decreased regularly. Connective tissue had penetrated the pores and totally invaded the implants, first at the periphery of the implants, then inside the pores. Comparison of the results of radioactivity and histomorphometry suggest that part of the calcium from the implants was re-used specifically in the new osseous tissue.