Biomedical subjects

B Balkau

Publications and source records attributed to B Balkau.

130 records · Page 8Linked to original sources

PubMedDate not supplied

[Larger waist circumference is a predictive factor for the occurrence of microalbuminuria in a non-diabetic population].

Obesity and insulin resistance are directly associated with the presence of microalbuminuria. However, the prospective relationship between abdominal adiposity and the occurrence of micro-albuminuria has been little studied in a non-diabetic population. From the DESIR cohort, we examined whether waist circumference was associated with the incidence of micro-albuminuria at 6 years (D6). The study evaluated 2738 non-diabetic subjects without micro-albuminuria at inclusion who were then followed prospectively. At 6 years, 254 individuals (9.3%) had developed pathological micro-albuminuria (> or =20 mg/l) measured at micturation. In both sexes, the incidence of micro-albuminuria was associated with increased waist circumference and blood pressure, but not with blood glucose levels, lipid parameters or body mass index. Subjects with a higher waist circumference at inclusion were at a higher risk of having micro-albuminuria at 6 years compared to those with a normal waist circumference. Logical regression analysis showed that waist circumference as a continuous value, or greater than 94 cm for males and 88 cm for females, were predictive factors for the incidence of micro-albuminuria, after adjustment for age, hypertension, ACE inhibitor usage, fibrinogen, and blood glucose level. Abdominal adiposity is thus linked in both sexes to the development of microalbuminuria, which underlines the importance of measuring waist circumference when assessing risk factors for renal lesions in non-diabetic hypertensives.

Adiposity↗

PubMedDate not supplied

[Analysis of diabetes-related mortality in France (1970-1987) from multiple causes of death].

The aim of this study was to analyse the characteristics and the mortality rate of diabetic patients, in France, between 1970 and 1987, as well as the association between diabetes and other pathologies at death. These results are based on both the underlying and the associated causes of death registered on the death certificate, in contrast to most studies which use only the underlying cause. In 1987, there were 16,790 deaths in France for which diabetes was mentioned on the death certificate (as the underlying cause in 38% of cases). There was a higher mortality in male diabetic subjects then in female, for all ages except over 75 years. Between 1970 and 1987, the mortality decreased for both sexes, except for the oldest age group. The death rate varied greatly between geographical regions. A particularly high mortality occurred in the Nord-Pas-de-Calais, Lorraine and Alsace. Diabetes was significantly associated, at death, with other diseases and pathologies. The most frequent were vascular diseases (ischaemic heart disease, cerebral diseases and hypertension) and diseases of the genitourinary system. It if of note that 5% of the death certificates of these diabetic subjects indicated diabetic coma as a cause of death.

Adult↗

PubMedDate not supplied

Diabetes and pancreatic carcinoma.

OBJECTIVE: To analyse the association between pancreatic cancer and non-insulin-dependent diabetes mellitus. DESIGN: Cohort study of fatal pancreatic cancer with 17 years of follow-up. SETTING: Working men in Paris. PARTICIPANTS: 6,988 men aged 44-55 years employed by a government agency. Following a 75 g oral glucose tolerance test, subjects were classed at baseline, according to the WHO criteria as normoglucose tolerant, impaired glucose tolerant or diabetic. Known diabetic patients were grouped with the latter. RESULTS: Among the 312 diabetic subjects (both known and newly diagnosed) the death rate from pancreatic cancer was 64 per 100,000 person years, and 28 and 18 per 100,000 person years among the 684 impaired glucose tolerant and 5,992 normoglycaemic subjects respectively. After the exclusion of deaths during the first five years of follow-up, a possible marker of occult cancer at baseline, the relative risk of fatal pancreatic cancer in diabetic versus normoglycaemic men was 4.9 (95% CI, 1.3 to 18 after adjustment for age and tobacco consumption).

Adult↗

PubMedDate not supplied

Android fat distribution by age and sex. The waist hip ratio.

The waist hip ratio, an indicator of upper body fat distribution, is an early sign of atherogenic disease and diabetes risk. The distribution of the waist hip ratio in 18,393 members of the French population aged 17 to 60 years is described according to sex and five year age groups. Men had a higher mean waist hip ratio (0.913 vs 0.791, p < 0.001) and women a higher standard deviation (0.074 vs 0.067, p < 0.001). The distributions overlapped by only 33%. Sex-specific figures show the waist hip dispersion according to age. If this parameter is a reliable clinical indicator in cardiovascular and metabolic epidemiology these descriptive data are essential. They precede the study of possible associations between the waist hip ratio and the risk factors for insulin resistance, atherogenic diseases and diabetes.

Adipose Tissue↗