Biomedical subjects
B B Wilson
Publications and source records attributed to B B Wilson.
Nail unit basal cell carcinoma: a case report and literature review.
Explore the source record for details and available documents.
Nonpigmented dysplastic melanocytic nevi.
BACKGROUND: Dysplastic melanocytic nevi (DMN) are thought to represent a clinical and histologic bridge between common pigmented nevi and superficial spreading malignant melanoma. The following clinical criteria for DMN were established to aid in the proper identification of these lesions: irregular perimeter, size exceeding 5 mm in diameter, background erythema, and variegated color (shades of browns, tans, blacks, and reds). Histologic features include basilar melanocytic proliferation with nuclear atypia, a patchy lymphocytic infiltrate with concentric eosinophilic fibroplasia, and lamellar fibroplasia. To our knowledge, there have been no previously reported cases of uniformly nonpigmented DMN. OBSERVATIONS: A 31-year-old brown-haired, browneyed white woman with no personal or family history of either DMN or melanoma presented for evaluation of numerous, discrete, nonindurated, 2- to 5-mm-diameter, nonpigmented macules and slightly elevated papules that had appeared in a truncal distribution over the course of several years. Microscopic examination of these lesions showed lentiginous epidermal hyperplasia and disordered proliferation with variable cellular atypia of intraepidermal melanocytes. CONCLUSIONS: Nonpigmented, nonindurated, macular or slightly elevated papular lesions may represent nevi with features of dysplasia. In light of the significant risk of malignant melanoma that is associated with pigmented varieties of dysplastic nevi, it is essential that clinicians consider nonpigmented DMN in the differential diagnosis of entities that present as hypopigmented macules.
Case report: Class III tendency treatment. Fixed and removable appliances.
Explore the source record for details and available documents.
Slowly enlarging, erythematous macule in a child. Tufted angioma.
Explore the source record for details and available documents.
Effect of combined antibacterial and antifungal treatment in severe atopic dermatitis.
Explore the source record for details and available documents.
Erosion of psoriatic plaques: an early sign of methotrexate toxicity.
Methotrexate is an effective but potentially toxic treatment for psoriasis. Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration. Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression. We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.
Miliaria profunda.
Miliaria profunda is an uncommon but highly characteristic disorder that can be disabling. We describe a patient with miliaria profunda who responded to therapy with anhydrous lanolin and isotretinoin. Clinical features, pathogenesis, differential diagnosis, and therapy are reviewed.
Panoramic and transcranial radiology in orthodontics and craniomandibular disorders.
A good summary for the uses of TMJ radiographs was presented by Jeff Okeson in 1989 as follows: "Radiographs have limited use in the identification and treatment of TM disorders. Only through collaboration with clinical findings and history do they gain significance. When there is reason to believe that an organic joint pathosis exists, radiographs of the temporomandibular joints are obtained. Transcranial and panoramic views are used as screening devices for general assessment of bony abnormalities and osteoarthritic changes. Functional movements are also evaluated and correlated with clinical findings. Tomography is reserved for patients in whom the screening radiographs reveal a possible abnormality that needs closer visualization and investigation. Arthrography is a specialized diagnostic tool to be used only when significant doubt exists regarding the position of the articular disc. CT and MRI are reserved for when additional information will improve the adequacy of the diagnosis." I could not improve upon this summary but would like to point out that Jeff is labeling both panoramic imaging and transcranial imaging as screening devices to be later followed up with more definitive type imaging.
Spontaneous improvement of a port wine stain.
A 3-year-old child had been born with an extensive vascular lesion that was clinically and histologically consistent with a port wine stain. Between the ages of six months and three years the lesion showed a remarkable degree of spontaneous resolution. This degree of improvement is exceptional after the age of six months and is documented photographically in this report.
Linear lichenoid graft-vs-host disease.
Explore the source record for details and available documents.
Atopic dermatitis associated with dermatophyte infection and Trichophyton hypersensitivity.
An atopic patient with tinea unguium, immediate hypersensitivity to Trichophyton, and elevated specific IgE antibody to Trichophyton had recalcitrant hand and foot eczema that resolved following the administration of systemic antifungal therapy for her tinea unguium. The patient fulfills criteria for the atopic-chronic-dermatophytosis syndrome described by Jones. The authors suggest that the patient's atopic dermatitis may have been exacerbated by her chronic dermatophyte infection and Trichophyton hypersensitivity.
Eruptive xanthomas during pregnancy.
A case of eruptive xanthomas during two successive pregnancies is reported. These xanthomas developed in association with marked hypertriglyceridemia; complications included severe pancreatitis and acute respiratory distress syndrome. This patient most likely had combined familial hyperlipidemia which usually causes only a modest elevation in plasma lipid levels. However, with the added stimulus of estrogens during pregnancy, hypertriglyceridemia and secondary complications developed.
Indurated telangiectatic plaques. Malignant angioendotheliomatosis (MAE).
Explore the source record for details and available documents.
Multiple papules on the leg. Multiple piloleiomyomas.
Explore the source record for details and available documents.
Late-onset nevus of Ota.
We report a patient with a type IB nevus of Ota whose lesion did not appear until she was thirty years old. To our knowledge, this represents the oldest age of a patient at clinical onset of nevus of Ota. The diagnosis, implications, and treatment of nevus of Ota are reviewed.
Papular acne scars. A common cutaneous finding.
One hundred thirty-three patients were examined for the presence of a cutaneous eruption consisting of small, asymptomatic, hypopigmented, follicular papules on the upper part of the trunk. The papules were present in 57% of patients who had a history of acne vulgaris and in 9% of patients who denied ever having had acne. Biopsy specimens from five patients revealed circumscribed, perifollicular or parafollicular lesions in which both elastic and collagen fibers were attenuated in comparison with those in normal adjacent dermis. These changes are consistent with scar. We conclude that the papules are a scarring process secondary to acne vulgaris and propose calling the lesions papular acne scars. They appear closely related to or identical with changes previously termed perifollicular elastolysis, postacne anetoderma-like scars, and papular elastorrhexis.
Eruptive disseminated lobular capillary hemangioma (pyogenic granuloma).
A 43-year-old man reported a 2-month history of numerous widespread vascular lesions that had developed suddenly on his scalp, trunk, and extremities. The lesions were 2 to 6 mm in diameter, firm, dark red papules that bled easily with minor trauma. Histopathologic examination of four lesions revealed lobular capillary hemangioma, also known as pyogenic granuloma. Treated lesions did not recur after surgical excision or electrocauterization. Five months after the onset of the eruption, no new lesions were developing, and some were resolving spontaneously after bleeding. Eruptive, disseminated lobular capillary hemangioma is a rare, self-limited cutaneous disorder that occurs in otherwise healthy persons.