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Biomedical subjects

B B Scott

Publications and source records attributed to B B Scott.

At least 91 records · Page 5Linked to original sources
PubMed1976

Patchiness and duodenal-jejunal variation of the mucosal abnormality in coeliac disease and dermatitis herpetiformis.

The incidence and degree of patchiness of mucosal abnormality in both coeliac disease (CD) and dermatitis herpetiformis (DH) is documented. As judged by both stereomicroscopy and subjective histology, patchiness occurred frequently in both CDand DH patients. In most cases the difference of abnormality was of only one grade, but in approximately 25% as assessed by stereomicroscopy and 10% as assessed by histology the difference was of two or more grades. In control subjects with normal small bowel mucosa the variation of the mucosal appearance between the duodenum and proximal jejunum was studied. Contrary to popular belief, no significant difference of villous and crypt measurements or of apparent villous "bridging" and "branching" between these two sites was found, if only well-orientated sections were studied. The stereomicroscopic appearances were also similar at these two sites, although villi tended to be broader in the duodenal biopsies. The duodenal-jejunal variation was also studied in CD and DH patients and although by both stereomicroscopy and subjective histology the appearances were similar in most patients, in approximately 33% the duodenal abnormality was the most severe and, surprisingly, the jejunal abnormality was more severe in approximately 15%. It is concluded that multiple, precisely located biopsies of both the duodenum and proximal jejunum are invaluable in the investigation of small bowel disease and in assessing response to treatment.

Biopsy↗
PubMed1976

Peroral small-intestinal biopsy: experience with the hydraulic multiple biopsy instrument in routine clinical practice.

Experience of the peroral, hydraulic, multiple, small-bowel biopsy instrument is recorded and compared with reported experience of other peroral biopsy instruments. It is concluded that, in routine clinical practice, there is no particular danger associated with this instrument despite warnings to the contrary. Furthermore, biopsies are obtained at least as quickly as with other instruments and with great reliability. Since this instrument also enables multiple, precisely located biopsies to be taken from various levels of the small intestine, it could be considered the instrument of choice for peroral jejunal biopsy.

Adolescent↗
PubMed1976

Viral antibodies and chronic liver disease.

Serum rubella, measles and cytomegalovirus antibodies were measured in patients with various forms of chronic liver disease and compared with those in age-matched controls. In CAH all three antibodies were found in significantly greater titre than in controls,and in cryptogenic cirrhosis titres to rubella were significantly increased. In alcoholic cirrhosis none was increased. There was no correlation between antibody titres and either the presence of portal-systemic shunts or the use of steroids. In patients with CAH measles titres were significantly related to the presence of ANF and SMA.

Antibodies, Antinuclear↗
PubMed1976

Cell-mediated autoimmunity in coeliac disease.

Lymphocyte transformation in response to a crude freeze-dried prepartion of whole jejunal mucosa was studied in fifteen patients with coeliac disease and compared with the findings in fifteen age-matched controls. The transformation ratio was markedly increased in three patients. These observations suggest the possible existence of cell-mediated autoimmunity to jejunal mucosa in some patients with coeliac disease and might be relevant to the development of some of the complications of the disease.

Adolescent↗
PubMed1975

Coeliac disease: a cause of various associated diseases?

Deposition in other organs of immune complexes originating from the small-intestinal musosa is suggested as a possible reason, in some patients, for the described association between coeliac disease and a range of "autoimmune" diseases.

Antigen-Antibody Complex↗
PubMed1975

Involvement of the small intestine in systemic mast cell disease.

A patient is reported with mast cell infiltration of the small intestine in the absence of the skin involvement characteristic of mast cell disease. She also had subtotal villous atrophy responsive to a gluten-free diet. Criteria for diagnosing mast cell disease of the small intestine are proposed. The literature of small intestinal mast cell disease is reviewed and the relationship to coeliac disease is discussed.

Adult↗
PubMed1974

Interpretation of serum creatine kinase in suspected myocardial infarction.

Serum creatine kinase (CK) was measured in blood donors, patients admitted to hospital with suspected myocardial infarction, and healthy hospital personnel to investigate the normal range, the daily variation in healthy people, and the effect of intramuscular injections of pentazocine or diamorphine.There was considerable daily variation in the healthy controls, apparently related to exercise. In defining both the normal range and the significance of day-to-day increases in the serum CK account should be taken of this factor. An upper limit of normal of 210 IU/1. Should apply to previously ambulant patients and of 165 IU/1. to patients previously at rest. An increase greater than 85% in successive daily values is uncommon in health.Intramuscular injections of both pentazocine and diamorphine caused a significant rise in the serum CK in six out of 25 patients. The highest rise observed was from 64 IU/1. to 395 IU/1. Caution is therefore urged in the diagnosis of myocardial infarction from the serum CK values when these intramuscular injections have been given.

Circadian Rhythm↗