The metabolic and phagocytic activities of leukocytes from children with acute leukemia.
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Adolescent↗
Biomedical subjects
B B Paul
Publications and source records attributed to B B Paul.
The metabolic and phagocytic activities of leukocytes from children with acute leukemia.
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Adolescent↗
The role of the phagocyte in host-parasite interactions. XX. Restoration of x-irradiation phagocytic damage by endotoxin or polyadenylic-polyuridylic acids.
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Adenine Nucleotides↗
Role of the phagocyte in host-parasite interactions. XXII. H2O2-dependent decarbosylation and deamination by myeloperoxidase and its relationship to antimicrobial activity.
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Alanine↗
The role of the phagocyte in host-parasite interactions. XIX. Leukocytic glutathione reductase and its involvement in phagocytosis.
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Animals↗
Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphonuclear leukocytes.
The anti-inflammatory drug phenylbutazone has been found to inhibit both engulfment and intracellular killing of E. coli by guinea pig peritoneal polymorphonuclear (PMN) leukocytes. The bactericidal activity of leukocytic homogenates was also inhibited by the drug. Addition of the drug at various time intervals to a phagocytic reacting system caused an almost immediate cessation of bactericidal activity. Metabolic studies showed that the drug sharply curtailed glucose-l-(14)C and (14)C-formate oxidation of both resting and phagocytizing PMN leukocytes. These data indicated an effect upon the hexose monophosphate shunt and H(2)O(2) formation. Further investigation showed that the sites of inhibition were on glucose-6-phosphate and 6-phosphogluconate dehydrogenase. These inhibitions resulted in decreased H(2)O(2) production. It is suggested that H(2)O(2) activates lysosomes and subsequently complexes with the lysosomal enzyme, myeloperoxidase. This complex is a potent bactericidal agent in the phagocyte.
Animals↗