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Biomedical subjects

B B Dorwart

Publications and source records attributed to B B Dorwart.

At least 19 recordsLinked to original sources
PubMed1985

Collagen synthesis and collagenase activity in dermal fibroblasts from patients with diabetes and digital sclerosis.

Collagen production and collagenase activity were measured in dermal fibroblast cultures obtained from eight patients with diabetes with digital sclerosis and three normal controls. Total collagen synthesis in patients with diabetes was reduced in comparison with controls. DNA replication was also reduced in patients with diabetes. No differences in collagenase activity were noted. Our results suggest that, in contrast to systemic sclerosis, increased synthesis does not contribute to the collagen accumulation of diabetic digital sclerosis. Decreased degradation related to nonenzymatic glucosylation of collagen is a more likely mechanism.

Adult↗
PubMed1985

Symmetric myositis and fasciitis: a complication of sickle cell anemia during vasoocclusion.

Repeated episodes of symmetric myositis and fasciitis occurred in 2 males with sickle cell anemia after prolonged painful crises. Drugs and infection could not be implicated as a cause. Histologically and therapeutically these cases differ from all other known types of myositis/fasciitis. Microscopic evidence of vasoocclusion compels consideration of an ischemic basis for this previously undescribed entity.

Adult↗
PubMed1985

Occurrence of De Quervain's tendinitis during pregnancy.

Six women developed De Quervain's tenosynovitis during pregnancy. Onset was never before the fifth month. Two patients also had carpal tunnel syndrome. In two otherwise untreated patients, tendinitis resolved only after discontinuation of nursing. We discuss the possibility of association with hormonal changes occurring during pregnancy.

Adult↗
PubMed1984

Carpal tunnel syndrome: a review.

Compression of the median nerve in the crowded carpal tunnel is common and frequently incapacitating. Its causes and associated clinical conditions are multiple. Diagnosis is made by the typical history, three frequently positive physical signs at the wrist, and, if necessary by median nerve conduction velocity impairment. Most patients can be managed medically; when surgery is required it can be done usually without general anesthesia on an outpatient basis with gratifying results.

Abnormalities, Multiple↗
PubMed1984

Rheumatoid arthritis.

Rheumatoid arthritis is a very common disease with potentially serious disability in patients of all ages. Therefore, early suspicion of the diagnosis, appropriately aggressive therapy, and close follow-up of patients are essential.

Anti-Inflammatory Agents↗
PubMed1981

Arthritis in beta thalassaemia trait: clinical and pathological features.

A 33-year-old white female of English descent with beta thalassaemia trait developed painful recurring bilateral knee effusion at age 15 years. Trauma was denied. Synovial analyses revealed noninflammatory effusions with normal complement, no inclusions, and no crystals. Knee x-rays normal at ages 18 and 26, showed mild osteoarthritic changes at age 33. Laboratory tests for other known causes of arthritis were repeatedly normal or negative. Bone densitometry was below normal. Light microscopy of the synovial membrane showed no significant abnormalities and no iron deposition. Electron microscopic findings included multilamination of vascular basement membranes and large amounts of thin fibrils surrounding many connective tissue cells. Treatment with salicylates did not prevent recurrence of effusions, and quadriceps strengthening and joint rest were moderately successful in relieving pain. Intra-articular corticosteroids on 2 occasions were not helpful. Whether her knee arthritis is purely secondary to the para-articular bone thinning from the chronic marrow expansion remains to be determined.

Adult↗
PubMed1979

Articular manifestations of polymyositis and dermatomyositis.

Nine patients with polymyositis or dermatomyositis associated with arthritis without antinuclear antibodies have been studied. In eight patients a mildly inflammatory nonerosive arthritis occurred coincident with early manifestations or before the appearance of symptomatic muscle disease. Hands, wrists and knees were prominently involved. This arthritis responded to corticosteroids given for the myositis. One patient had erosive arthritis and periarticular calcifications associated with acute inflammation that seemed to diminish with colchicine therapy. Synovial biopsy specimens showed surface fibrin deposition, focal loss of lining cells and mild inflammation--findings similar to those in scleroderma. By electron microscopy tubuloreticular structures were found in vascular endothelium in synovium, as in other tissues in polymyositis. All patients surprisingly had pulmonary manifestations suggesting the possibility that the condition in this group of patients may represent a distinctive subset of polymyositis.

Adult↗
PubMed1977

Chronic synovitis with early cartilage destruction in sickle cell disease.

Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less common than the frequent transient effusions in sickle cell disease.

Adult↗
PubMed1975

Joint effusions, chondrocalcinosis and other rheumatic manifestations in hypothyroidism. A clinicopathologic study.

Twelve patients with severe hypothyroidism and rheumatic signs and symptoms were studied before or within four days of receiving thyroid replacement therapy. Eight patients had synovial effusions. Seven effusions were extremely viscous and six contained calcium pyrophosphate crystals. Leukocyte counts were less than 1,000/mm3, except in two patients during crystal-induced synovitis. "Bulge signs" were present but often sluggish, possibly because of the viscosity of the fluid. Flexor tendon sheath thickening, joint laxity and popliteal cysts were documented. All patients complained of generalized stiffness and two had proximal myopathy. Roentgenograms were obtained in 11 patients, and chondrocalcinosis was identified in seven. Needle synovial biopsy specimens in five patients showed only mild inflammation in the thick synovium. These findings can suggest hypothyroidism, a treatable disease, as the cause of musculoskeletal problems.

Aged↗