Search PubMed⌕ Search

Biomedical subjects

B Aruna

Publications and source records attributed to B Aruna.

2 recordsLinked to original sources

Multiobjective GAs, quantitative indices, and pattern classification.

The concept of multiobjective optimization (MOO) has been integrated with variable length chromosomes for the development of a nonparametric genetic classifier which can overcome the problems, like overfitting/overlearning and ignoring smaller classes, as faced by single objective classifiers. The classifier can efficiently approximate any kind of linear and/or nonlinear class boundaries of a data set using an appropriate number of hyperplanes. While designing the classifier the aim is to simultaneously minimize the number of misclassified training points and the number of hyperplanes, and to maximize the product of class wise recognition scores. The concepts of validation set (in addition to training and test sets) and validation functional are introduced in the multiobjective classifier for selecting a solution from a set of nondominated solutions provided by the MOO algorithm. This genetic classifier incorporates elitism and some domain specific constraints in the search process, and is called the CEMOGA-Classifier (constrained elitist multiobjective genetic algorithm based classifier). Two new quantitative indices, namely, the purity and minimal spacing, are developed for evaluating the performance of different MOO techniques. These are used, along with classification accuracy, required number of hyperplanes and the computation time, to compare the CEMOGA-Classifier with other related ones.

Algorithms↗

Electron spin echo studies of hemoglobin cyanide and nitroxide derivatives.

Electron spin echo envelope modulation studies are performed on human hemoglobin cyanide, hemoglobin nitroxide and hemoglobin nitroxide + inositol hexaphosphate at neutral pH. The modulation data are Fourier transformed and are analyzed in the frequency domain. The frequency components observed from hemoglobin cyanide indicate modulation from the coordinated nitrogen N-1 of the proximal imidazole (His-F8). In the case of hemoglobin nitroxide, the binding of inositol hexaphosphate causes the nitrogen N-3 of the proximal imidazole to be protonated in some of the subunits. From a comparison with other studies on these derivatives of hemoglobin, these subunits are identified as the alpha-subunits.

Electron Spin Resonance Spectroscopy↗