Search PubMed⌕ Search

Biomedical subjects

B Arlt

Publications and source records attributed to B Arlt.

14 recordsLinked to original sources
PubMed2003

[The MEDAN database: patients with abdominal septic shock].

Septic shock still has an unacceptable high mortality rate. To lowering this high mortality rate in the long run, we built a database that is unique in its data amount. Until now we have transferred 282 handwritten patient records into our database. Data were collected retrospectively from 1997 to 2001, based on voluntary cooperation of 62 hospitals. With the preprocessed data of our database we give mainly an epidemiologic overview and make first statistical evaluations. Thereby we noticed that some diagnoses and operations appear significantly higher for deceased patients than for survivors. At the end we discuss the future potential of the database.

Adult↗
PubMed1997

[Diabetic foot].

Diabetics suffer from a high rate of amputation. Unclear terminology is partially responsible. We offer a clear classification (type A = PAOD; type B = polyneuropathy; type C = combination of A + B). Our classification for plantar ulcer is simple and yields clear indications for appropriate therapy. The operative principles for type B, foot will be discussed (dorsal incision, distal two-thirds resection of metatarsals, proper coverage of bones with soft tissues, necrectomy, placement of Gentamycin-bonded collagen sponge, drainage, primary wound closure, plantar ulcer left untouched). In a collection of 284 treated type B diabetic feet, in only 6% of cases was there secondary wound healing. The plantar ulcer was always cured.

Antibiotic Prophylaxis↗
PubMed1978

[Incompatibility reactions following the infusion of colloidal volume substitutes during anesthesia].

A case of incompatibility reaction after Macrodex infusion during anesthesia is reported. The possibility of activating the so-called "alternative pathway" by dextran is shown. The early recognition of this reason for incompatibilities may help to prevent the development of severe, possibly fatal forms of dextran incompatibility. Strict observation of the patient during, especially at the beginning of the infusion and an exact recognition of the symptoms are necessary if dextran infusions are applied.

Adult↗
PubMed1978

[The immunohistochemical demonstration of the Thiol: proteindisulfid oxidoreductase (TPO) in pancreas and isolated Langerhans'islets. A light-, fluorescent- and electron microscopic study (author's transl)].

Thiole: Protein disulfide Oxidoreductase (E. C. 1.8.4.2) is capable of catalyzing thiole-disulfid exchange reactions and might have an important function in both protein biosynthesis and degradation. By using histochemical methods we were able to demonstrate the localization of this enzyme in the Langerhans'islets and in the acinus cells of rat pancreas. The reaction of the acinus cells, however, was much weaker than that of the islets. Electron microscopic experiments revealed the enzyme to be located in the outer membrane of the nucleus, in the membranes of the endoplasmic reticulum and B-cell granules, and in the plasmalemma also. All these structures are known to be involved in the insulin biosynthesis and secretion. There is a good correlation between morphological and biochemical findings. In acinus cells there are a few reaction in the outer nucleus membrane, the membranes of the endoplasmatic reticulum, and the plasmalemm.

Animals↗
PubMed1978

[The immunhistochemical investigation of trypsin and trypsin-like-activity in the small intestine, pancreas and isolated Langerhans islets. A light-, fluorescent- and electron microscopic study (author's transl)].

By means of the indirect immunofluorescence and immunenzyme technique trypsin and trypsin-like activity in fixed cryostate sections of pancreas and gut and pellets of isolated pancreatic islets respectively were investigated using specific antiserum against trypsin. The enzyme was demonstrated in the cytoplasma of the acinus cells, the epithel cell of the intercalated ducts and the excretory (interlobular) ducts of the exocrine pancreas. By light and fluorescence microscopy we could also localize a high activity in pancreatic islets. Results taken from electron microscope show the enzyme in the region of the peripheral endoplasmatic reticulum, the surface of the mitochondria, the zymogen granules of the acinus cells and in the region of the membranes of the endoplasmatic reticulum and in the granules of the B-cells of the pancreatic islets. These results are discussed in correlation with biochemical data concerning the importance of trypsin/trypsin-like activity in the specific conversion of prohormones into hormones.

Animals↗