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Biomedical subjects

B Amor

Publications and source records attributed to B Amor.

At least 127 records · Page 7Linked to original sources
PubMed1989

[Neuro-rheumatologic manifestations in patients infected with the AIDS virus].

We are reporting 3 cases of lumbo-radiculalgia, simulating the usual picture of herniated disc, and revealing complications related to the virus of acquired human immunodeficiency (HIV). Rheumatologists must be aware of any atypical clinical signs in patients suffering from lumboradicular disease, and search for a HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Epitope mapping of HLA-B27 and HLA-B7 antigens by using intradomain recombinants.

To study the HLA-B7 and HLA-B27 antigenic determinants, hybrid genes between these two alleles were constructed by in vivo recombination in Escherichia coli. After transfection of these genes into P815 (high transfection efficiency recipient) murine cells, the bindings of Bw6, HLA-B7, and HLA-B27 allele-specific mAb were studied, as well as that of human anti-HLA-B7 and anti-HLA-B27 monospecific alloantisera. Most of the HLA-B7 antigenic determinants were assigned to the first external domain of the molecule. Four different epitopic areas could be defined: the Bw6 epitope was associated with residues 82 and 83; the BB7.1 epitope to amino acids 63, 67, and 70; the MB40.2 and MB40.3 epitope to amino acid sequence 177-180, and human alloantisera identified as an epitope associated with residue 9. HLA-B27 antigenicity studied by TM-1 mAb was found to involve residues 77 and 80 in the alpha-1 domain. Results obtained with human monospecific alloantisera allowed the definition of an additional allospecific site associated with the NH2 terminal part on the alpha-1 domain of HLA-B27. Epitope mapping fits with data obtained by sequence comparisons and is discussed with reference to the crystallographic three-dimensional structure of the HLA-A2 molecule.

Amino Acid Sequence↗
PubMed1988

[Acadione, a new long-term treatment of rheumatoid polyarthritis].

This article summarizes the authors' experience and data from the literature regarding acadione, a medication like D-penicillamine with a thiol radical, in the treatment of rheumatoid arthritis. Two control studies versus placebo and two control trial versus D-penicillamine prove the effectiveness of the treatment and demonstrate a similar activity between 1 g of acadione and 600 mg of D-penicillamine. The side-effects of acadione are similar of those of D-penicillamine, essentially rash, toxic dermatitis, agueusia, proteinuria, which disappear upon discontinuation of the treatment. The fact that the patient exhibited a side effect with D-penicillamine, increases, the risk with acadione, but this is not systematic, which is the main advantage of this product.

Amino Acids, Sulfur↗
PubMed1988

[Morphological variations of the lumbar foramina during flexion-extension and disk collapse].

The authors have studied, on anatomical preparations, the variations in shape and size of 38 intervertebral foramina during flexion-extension movements, on spines which were free of degenerative lesions; they also studied the same variations following an isolated disc collapse. The cast technique takes into account the bony prominences, the bulge of the disc anteriorly, and the capsulo-ligamentous structures posteriorly. In flexion, all the diameters of the foramina are maximum. In extreme extension, all diameters decrease significantly; the pedicles come closer together, the disc bulges posteriorly and the ligamentum flavum pushed by the superior articular process of the underlying vertebra, projects forward. When the height of the disc is preserved, the reduction in size of the foramen does not compress the nerve root. A moderate disc collapse of 4 mm decreases all the diameters and under those circumstances, lumbar extension results in a sufficient decrease of the diameter of the foramen to threaten the nerve root, even in the absence of posterior articular osteophytes.

Adult↗
PubMed1988

[Plasma levels of vitamins A and E in hyperostosis, ankylosing spondylarthritis and rheumatoid polyarthritis].

In animal and man, chronic intoxication with vitamin A or retinoids may be responsible for vertebral hyperostosis and periosteal appositions. Vertebral hyperostosis is found in hyperostotic disease but also in the course of ankylosing spondylarthritis. Therefore, we felt it would be interesting to study blood retinol levels in 22 patients with hyperostotic disease, 29 patients with ankylosing spondylarthritis, 18 patients with rheumatoid polyarthritis and 21 reference patients. The Kurskal-Wallis test has demonstrated a significant difference of blood retinol levels between these four groups (p less than 0.0001). The blood retinol level was more elevated during hyperostotic disease (3.63 +/- 1.13 mumol/l) than in the reference group (2.94 +/- 0.76) and was, on the contrary, lower during ankylosing spondylarthritis (2.57 +/- 0.66) and rheumatoid polyarthritis (2.32 +/- 0.64). This study confirms the elevation of blood retinol during the course of hyperostotic disease; such a abnormality was not demonstrated in the course of ankylosing spondylarthritis, and on the contrary, suggest that a decreased blood retinol level may be observed during chronic inflammatory rheumatic diseases such as rheumatoid polyarthritis or ankylosing spondylarthritis.

Adult↗
PubMed1988

Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients.

The efficacy and safety of cyclosporin A (CyA) for patients with rheumatoid arthritis were assessed in a four month double blind, placebo controlled study using an initial dosage of 5 mg/kg daily. Six patients withdrew from the study (two in the placebo group because of inefficacy of treatment and four in the CyA group because of side effects). These six patients were considered therapeutic failures. At the end of the trial the study treatment was considered as good or very good by 14 out of the 26 CyA group patients and by only two out of the 26 placebo group patients. Moreover, in the CyA group significant improvement was observed in five of the seven clinical assessment criteria. Clinical improvement was correlated with a decrease in C reactive protein, alpha 1 glycoprotein levels, and platelet count but not with erythrocyte sedimentation rate or rheumatoid factor titres. Renal toxicity (13 cases) remained the major problem in the management of these patients. This study shows that CyA is effective in active rheumatoid arthritis but requires close monitoring for toxicity.

Arthritis, Rheumatoid↗
PubMed1988

A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.

A double-blind multicenter cross-over study was conducted on 166 outpatients with painful chronic osteoarthritis of the hip and of the femoro-tibial joints, to compare the effectiveness of glafenine and paracetamol. Patients were randomly assigned to receive over a period of a week, either 400 mg of glafenine or 1000 mg of paracetamol twice a day at 8 a.m. and 4 p.m. in order to fill up the physical activity period during the daytime. This interval between tablet intake was chosen according to the design of the model. At the end of the week treatment period, patients crossed over. There was no wash out period between treatments. The following measurements: pain intensity (on Huskisson's visual analogue scale), functional index for hip and knee diseases, patients' overall opinion, patient preference, were evaluated at days 0, 7, 14. The results showed that both treatments produced effective analgesia but the improvement was significantly greater and observed in a larger number of cases when using glafenine rather than paracetamol. Fifty-one per cent of the nonresponsive patients to paracetamol could benefit from the glafenine treatment and 18 per cent of patients suffering from hip or knee osteoarthritis in this study showed improvement only with glafenine. Safety and biological tolerance were satisfactory with both drugs.

Acetaminophen↗
PubMed1988

[Long-term results of chymopapain nucleolysis].

The retrospective study of the first 67 patients treated by chemonucleolysis, since December 1980, shows a good overall result, in 69 p. cent of the cases (40 patients) and a failure in 31 p. cent of the cases (18 patients), with a 42 months follow-up. The radiculalgia is cured or quite improved in one month in 90 p. cent of the cases and in 2 years in 88 p. cent. Lumbalgia is absent or moderate after 1 month in 58 p. cent of the cases and after 2 years in 81 p. cent. It persists, most of the time, in women, and this is statistically significant. 15 immediate failures and 3 recurrent sciaticas at the same level are noticed after a 22 months free interval. The possibility of severe complications requires a perfect technique and well-defined indications. The study confirms the good results of nucleolysis with a 42 months follow-up.

Adult↗