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B Albrecht

Publications and source records attributed to B Albrecht.

58 records · Page 4Linked to original sources
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Origin of nondisjunction in trisomy 8 and trisomy 8 mosaicism.

Causes of chromosomal nondisjunction is one of the remaining unanswered questions in human genetics. In order to increase our understanding of the mechanisms underlying nondisjunction we have performed a molecular study on trisomy 8 and trisomy 8 mosaicism. We report the results on analyses of 26 probands (and parents) using 19 microsatellite DNA markers mapping along the length of chromosome 8. The 26 cases represented 20 live births, four spontaneous abortions, and two prenatal diagnoses (CVS). The results of the nondisjunction studies show that 20 cases (13 maternal, 7 paternal) were probably due to mitotic (postzygotic) duplication as reduction to homozygosity of all informative markers was observed and as no third allele was ever detected. Only two cases from spontaneous abortions were due to maternal meiotic nondisjunction. In four cases we were not able to detect the extra chromosome due to a low level of mosaicism. These results are in contrast to the common autosomal trisomies (including mosaics), where the majority of cases are due to errors in maternal meiosis.

Child↗
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Novel molecular and cellular strategies in cancer therapy.

Tumor initiation and progression results from several subsequent mutations in genes that control cellular proliferation and differentiation. Neoplasia may lead to the expression of antigens that may be derived from such oncogenes or the activation of other cellular or viral genes that may represent tumor associated antigens. This review summarizes the present understanding of these mechanisms in an effort to design new therapeutic strategies.

Dendritic Cells↗