A 37-year-old man developed persistent hemoptysis after sustaining a gunshot wound to the right shoulder and lung. A right upper lobectomy was performed, in which Aspergillus species microorganisms were identified within retained bullet fragments. The role of infected bullet fragments in the pathogenesis of hemoptysis in this patient is discussed.

Adult↗

PubMedDate not supplied

Priming and signal transduction in neutrophils.

The priming response is a common feature for almost all agents which activate neutrophils. The priming response is associated with a number of events such as degranulation, receptor upregulation, increases in [Ca2+]i and the production of lipid second messengers. For each of these associated events there are data to suggest that priming can also occur in their absence. These contradictions suggest that either the true mechanism for priming has not been found or that there are multiple pathways by which the primed state can be reached. The latter is more likely to be the case.

Calcium↗

PubMedDate not supplied

Mutagenicity of selected functionalized benz(c)acridines and a benz(a)phenazine in the Salmonella typhimurium/microsome assay.

Five functionalized benz(c)acridines - 5,6-dimethylbenz(c)acridine; 5,6,7-trimethylbenz(c)acridine; 7-chloro-5,6-dimethylbenz(c)acridine; 7-amino-5,6-dimethylbenz(c)acridine; 7-oxo-5,6-dimethylbenz(c)-acridine and 5,6-dimethylbenz(a)phenazine - were tested for mutagenic activity in the Ames Salmonella typhimurium assay. Compounds were initially screened by spot tests with 5 tester strains and both plate incorporation and pre-incubation assays were performed when the results of the tests were positive or weakly positive. All assays were done with and without S9 activation. 7-Amino-5, 6-dimethylbenz(c)acridine and 7-chloro-5, 6-dimethylbenz(c)acridine were found to be moderately mutagenic with the 3 frameshift strains TA1537, TA98, and TA97.

Acridines↗