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Biomedical subjects

B A Southgate

Publications and source records attributed to B A Southgate.

At least 37 records · Page 2Linked to original sources
PubMed1977

Preliminary studies on the histochemical differentiation of strains of Onchocerca volvulus microfilariae in Togo.

Skin snips were taken from 75 people living in four villages of northern Togo. The 7824 microfilariae that emerged were examined by staining for the presence of acid phosphatase. Four distinct patterns of enzyme staining were observed, and descriptions of the stained microfilariae are given. The study confirms the view that a number of biological strains or variants of Onchocerca volvulus coexist in West Africa, and suggestions are made for further research that could result in the practical application of these observations in onchocerciasis control programmes.

Animals↗
PubMed1976

Some observations on filariasis in Western Samoa after mass administration of diethylcarbamazine.

An extremely efficient diethylcarbamazine administration campaign to eradicate Wuchereria bancrofti has been carried out in Western Samoa. The use of the membrane-filtration technique has shown that a large number of people exhibit extremely low microfilarial densities, often with less than 10 in 1 ml of venous blood. It was found that one of these low level microfilaria carriers readily infected the local vector Aedes polynesiensis and that development took place to the infective stage. It was estimated that 497 infective larvae of W. bancrofti will enter the human population of Western Samoa daily from these vectors. Resumption of filariasis transmission is possible and surveillance of the human and mosquito populations should be continued for a number of years and control measures taken quickly if further transmission occurs.

Adult↗
PubMed1976

A new technique for the determination of microfilarial densities in onchocerciasis.

Precise measurement of the parasite load in helminthic infections makes it possible to correlate morbidity, the individual response to treatment, and the best control methods. A membrane filtration technique was recently developed for quantifying Wuchereria bancrofti microfilaraemia. The present paper describes its application to onchocerciasis in a study on 107 patients in northern Togo. The technique is cheap and simple to apply under field conditions, and is extremely efficient at recovering microfilariae from skin snips.

Adolescent↗
PubMed1976

Epidemiological studies on onchocerciasis by means of a new field technique.

A new membrane filter concentration technique for the detection and quantification of Onchocerca volvulus microfilariae in skin snips was compared for sensitivity and efficiency with a widely used "standard" technique. A field study was carried out in five villages in an onchocerciasis focus north-east of the town of Sokodé, Mô river valley, Togo. Use of the new technique resulted in a substantial rise in the observed prevalence and density of microfilariae.

Filarioidea↗
PubMed1974

Malaria in the United Kingdom.

Over the past decade the United Kingdom had the second highest number of cases of imported malaria among European countries. There has been a substantial rise in recorded cases of malaria during the past three years though some of it may be due to improved notification. Fatal cases of malaria in visitors to Africa have averaged 6.5% of reported infections due to Plasmodium falciparum. Attacks of vivax malaria may occur several months after travellers return from a malarious country.

Emigration and Immigration↗
PubMed1971

Clinical aspects of leishmaniasis with special reference to the USSR.

The wide variety of clinical syndromes produced in man by infection with members of the genus Leishmania has caused a great deal of confusion for many years, and has proved a serious obstacle to the rational classification of the leishmaniases.The situation has been complicated still further by the morphological identity of many species of Leishmania and by the behavioural similarities in vitro and in laboratory animals of species and strains producing distinct clinical or epidemiological patterns in humans. There has been a general failure to use standardized, comparable, and reproducible techniques in experimental studies of the various species of Leishmania; in particular, with one or two notable exceptions, there has been failure to adopt quantitative methods when studying Leishmania and the leishmaniases.This paper therefore attempts to classify the leishmaniases from clinical and epidemiological standpoints, and illustrates the provisional classification adopted with special reference to the situation in the USSR.

Africa↗