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Biomedical subjects

B A Shenderov

Publications and source records attributed to B A Shenderov.

At least 19 recordsLinked to original sources
PubMed1997

[Antimicrobial effects of medicines which are not antibiotics].

The data on antimicrobial activity of 69 different drugs not belonging to the class of typical antibiotics were examined. It was shown that many of them had antimicrobial activity against enterobacteria susceptible and resistant to antibiotics. Some of such drugs were able to eliminate the property of resistance to antibiotics and in particular that to chloramphenicol and tetracyclines. The data are indicative of the fact that many of the so called nonantibiotics have the capacity of active interference with the human microbial ecology.

Anti-Bacterial Agents↗
PubMed1996

[Role of anaerobic non spore-forming bacteria in maintaining human health].

The paper gives brief information on the fact that anaerobic non spore-forming bacteria take an active part in the metabolism of various substances and imbalance in their microscopic flora may be a trigger in the development of many human diseases. In the past 2 decades, Russia has been using various pharmaceuticals based on bifidobacteria, lactobacilli and their complexes, increasing colonization resistance, normalizing the pool of cholesterol, oxalic acid, free histamine, and making the liver function normally. Special emphasis is laid on the design of functional nutrition products by means of the above bacteria. It is emphasized that the industrial development of functional nutrition will determine human health in the twenty-first century.

Animals↗
PubMed1992

[The pathogenicity factors of bacteria in the genus Acinetobacter].

Eighty Acinetobacter strains, isolated in Togliatti from patients with purulent inflammatory diseases, were studied to determine their pathogenicity factors. Out of these 80 strains, 32.5% were found to have enterotoxigenic activity and 46.2%, adhesive activity. They were related to adhesins of the human type and to adhesins of the sheep, rabbit, swine and guinea pig types. But the most important phenomenon established in this study was the combination of different pathogenicity factors detected in Acinetobacter bacteria. Analysis of the combination of pathogenicity factors revealed that 7.5% of Acinetobacter strains had adhesive and enterotoxigenic activity, 15.3% of these strains combined adhesive and hemolytic activity and 1.2% of them were found to be enterotoxigenic and hemolytic. Only 5.0% of Acinetobacter strains were found to carry all there pathogenicity factors simultaneously.

Acinetobacter↗
PubMed1992

[Microbial ecology of laboratory animals as a model in evaluation of the immunomodulating and antimicrobial agents].

Rats with altered microbial ecology and decreased colonization resistance due to neutropenia induced by cyclophosphamide were used as a model for estimating the effect of bacterial polysaccharides (lactulose and exopolysaccharide from Bacillus polymyxa) and fluoroquinolones (pefloxacin). Monotherapy with pefloxacin had a favourable effect both on normalization on the intestinal microflora in the rats and their hemopoiesis (decreased neutropenia). The highest correcting effect with respect to the lowered colonization resistance was observed when pefloxacin was used in combination with exopolysaccharide.

Adjuvants, Immunologic↗
PubMed1991

[The effect of chemical preparations on the biological properties of the intestinal lactobacilli in experimental animals].

The oral administration of the therapeutic doses of tetracycline, pefloxacin, ampicillin, cephalexin, rifampicin, sisomicin to Wistar rats for 5 days was accompanied by a decrease in the total number of lactobacilli in feces and by changes of the species spectre of these microorganisms. In those rats species, never found in intact animals, could be revealed rather frequently. All antimicrobial preparations administered in this investigation induced a decrease in the proportion of antibiotic-sensitive cultures and led to the selection of strains having multiresistance and increased antagonistic activity with respect to Pseudomonas indicator strain. The possible relationship between the markers antibiotic resistance and antagonistic activity in lactobacilli is discussed.

Administration, Oral↗
PubMed1991

[Effect of antibiotics on fecal excretion of various products of microbial metabolism of aromatic amino acids].

The model experiments on intact albino rats and those exposed to lincomycin, ampicillin and rifampicin showed that intragastric administration of the three antibiotics to the laboratory animals in therapeutic doses for 8 days induced statistically significant changes in the fecal excretion of n-cresol, indole and skatole, microbial metabolites of aromatic amino acids in the gastrointestinal tract of a macroorganism. The results are in favour of using biochemical tests for rapid diagnosis of the intestinal microflora response to antimicrobial agents.

Amino Acids↗
PubMed1990

[Penicillin-binding proteins of various strains of Lactobacillus].

Sensitivity of different species of Lactobacillus i.e. L. casei, L. plantarum, L. acidophillus, L. buchneri, L. jugurti and others to penicillins and cephalosporins of various generations was studied. Penicillin binding proteins (PBPs) of the Lactobacillus species were specified. It was shown that the number of PBPs depended on the Lactobacillus species. L. casei had the least number of PBPs (4) and L. brevis had the highest number of PBPs (11). Competition of 14C-benzylpenicillin with ampicillin, cefotaxime, ceftizoxime and cefoperazone for binding to separate PBPs in three strains of different Lactobacillus species was investigated.

Ampicillin↗
PubMed1990

[Transfer of various markers in Lactobacilli during transformation of plasmid DNA and joint cultivation].

A system providing a high frequency genetic transfer of various markers making the reference strain Lactobacillus buchneri 1837 resistant to Lm, Em and Fus, able to ferment some carbohydrates and antagonistic against Pseudomonas diminuta CCM 2657 was developed. The frequency of the marker transfer during the lactobacilli joint cultivation was 1.5 X 10(-5) = 5.5 X 10(-5) to 1.5 X 10(-4) = 5.5 X 10(-4) which was 3-4 orders of magnitude higher than the marker transfer frequency during transformation of L. buchneri NRRLB 1837 with plasmid DNA of different lactobacilli. The recombinants and transformants resulting from the joint cultivation of lactobacilli contained a plasmid about 60 kb in length which provided cells of L. buchneri NRRLB 1837 with resistance to fusidin, antagonistic activity against Pseudomonas diminuta and capacity for utilizing sucrose and sorbite. It was shown possible to integrate the plasmid DNA about 26.5 kb in length contained in the cells of L. casei MT 205 to the chromosomes of erythromycin resistant transformants. The results of the investigation of the biological properties of the recombinants and transformants and their plasmid profiles were confirmed with the Southern DNA-DNA hybridization.

Anti-Bacterial Agents↗
PubMed1990

[Isolation of plasmid DNA from Bifidobacterium].

Conditions for accumulation of the biomass and a procedure for isolation of plasmid DNA from bifidobacteria in microquantities were developed. It was shown that all the strains tested had 1 to 3 plasmids of different molecular weights electrophoretically detected. Relation between the detected plasmid DNA and bifidobacteria resistance to tetracycline and fusidin as well as utilization of some carbohydrates is discussed.

Bifidobacterium↗
PubMed1989

[Effect of cephalexin on the colonization resistance of the large intestine in experimental animals].

It was shown morphologically and microbiologically that cephalexin administered intragastrically in a dose of 2 g/kg induced deep microecological changes in the cecum of Wistar albino rats. Scanning electron microscopy revealed that a single use of cephalexin in the above dose resulted in almost complete elimination of the biofilm from the surface of the cecum mucosa and it inflammation. This was accompanied by an increase in the number of potentially pathogenic bacteria and broadening of the spectrum of the phage variants of coliform bacilli present in the animal feces, as well as by change the periods of coliform bacilli persisting in the large intestine.

Animals↗