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Biomedical subjects

B A Shapiro

Publications and source records attributed to B A Shapiro.

At least 91 records · Page 5Linked to original sources

Generating non-overlapping displays of nucleic acid secondary structure.

A new algorithm is presented which permits the display of nucleic acid secondary structure by computer. This algorithm circumvents the problem of overlapping portions of the molecule which is inherent in some other drawing programs. The results from this algorithm may also be used as input to the drawing algorithm previously reported in this journal [1] to untangle most of a drawing. The algorithm also represents the molecule in a form which makes visual comparisons for similarity quite easy since it guarantees that comparable features will reside in the same relative position in the drawings when the drawings are normalized.

Base Sequence↗

Acute care/blood gas laboratories: profile of current operations.

A survey of acute care/blood gas laboratories was conducted through the memberships of the Society of Critical Care Medicine ( SCCM ) and the National Association of Medical Directors of Respiratory Care ( NAMDRC ). Data were obtained from 227 laboratories and analyzed for operational characteristics, personnel, analyses performed, and quality assurance procedures. Analyses included blood gases/pH, saturation, P50, oxygen content, hematocrit/hemoglobin concentration, as well as sodium, potassium, calcium, osmometry, and glucose. Application of appropriate quality control was uneven in terms of types and frequencies of procedures. Education of laboratory personnel ranged from high school to graduate degrees, with the greatest numbers having associate-level and baccalaureate-level educations . Certification of laboratory personnel primarily was through the National Board for Respiratory Therapy, although 36% of the personnel had no certification or registration. Aspects of the acute care laboratory identified as needing improvement are educational and certification requirements for laboratory personnel and application of quality control procedures. The database developed from this survey will serve for ongoing assimilation of information related to the operation of acute care laboratories.

Allied Health Personnel↗

Impact on ventilator-check time of an in-circuit computerized respiratory monitoring system.

To ensure appropriate quality control of mechanical ventilatory support in our institution, checks of patient status and ventilator performance are made every 2 hours. Our standard method of surveillance requires disconnecting the patient from the ventilator and connecting him to extraneous monitoring devices. We assessed the use of an in-circuit computerized respiratory monitoring system for ventilator surveillance and found that with this system significantly less therapist time was required to perform a check (5.8 +/- 1.18 minutes vs 9.9 +/- 1.53 minutes for the standard procedure) and that use of this system avoids the potential hazards associated with disconnecting a patient from the ventilator and introducing additional monitoring devices to the airway.

Chicago↗

The reliability of electrolyte measurements in plasma.

The difference between serum and plasma electrolyte measurements and the effects of delay, cooling and addition of sodium heparin on plasma electrolyte measurements were observed. Delay of more than 30 min from sampling to analysis renders plasma potassium measurements unreliable. All other factors assessed produced no changes in plasma electrolyte measurements. Arterial blood gas laboratories can, therefore, reliably provide rapid or serial measurements of plasma sodium and potassium provided the analysis is performed within 30 min of obtaining an appropriate arterial blood sample.

Cold Temperature↗

Respiratory management after cardiac surgery with inhalation anesthesia.

Improvements in cardiac surgery techniques and anesthetic management have given us cause to re-evaluate the necessity for postoperative mechanical ventilation and delayed extubation after open-heart surgery with inhalational anesthesia. One hundred consecutive patients undergoing various types of cardiac surgery were entered into this study; 94 patients met the requirements for spontaneous ventilation in the immediate postoperative time period and mechanical ventilation was not utilized. Of these 94 patients, 40 (45%) met extubation requirements within 90 min and were subsequently extubated. No patient required reintubation. Six (6%) patients failed to meet the requirements for spontaneous ventilation and, therefore, required mechanical ventilatory assistance postoperatively. In the majority of cardiac patients, the anesthetic technique determines postoperative ventilatory needs. Very poor preoperative physical status and unusually long procedures, however, will probably preclude early extubation or spontaneous ventilation and dictate the need for mechanical ventilation regardless of the anesthetic technique.

Adult↗

Review of a bronchial hygiene evaluation program.

In the 1970s the demand in our hospital for bronchial hygiene therapy (aerosols, IPPB, incentive spirometry, chest physical therapy) had increased to such a level that 20-30% of the ordered therapy was not being administered. Because the respiratory therapists and medical directors were convinced that much of the ordered therapy was unnecessary, the Respiratory Therapy Department began a program in 1978 in which specially trained respiratory therapists were authorized to evaluate all non-intensive-care patients for whom bronchial hygiene therapy had been ordered. The program protocol consists of a medical record review, a physical assessment of the patient, the development of a patient-care plan, and a re-evaluation every 2-3 days of the patient's continued need for therapy. We found that initiation of the program has led to improved documentation of the need for bronchial hygiene therapy and a significant decrease in total procedures performed, not merely a substitution of therapies. After being adjusted to the 1981 Consumer Price Index (CPI), total charges for bronchial hygiene therapy were markedly decreased even though hospital charges increased 77.4% above the CPI inflation rate. Since the program was begun, the respiratory therapy staff has been able to administer all ordered respiratory care services to patients in a critical care setting and not less than 90% of ordered bronchial hygiene therapy to patients outside the intensive care unit. House staff, attending physicians, and patients and their families appear to be satisfied with the therapist-evaluators, and the morale of respiratory therapists seems to have improved as a result of their being able to take a more role in the treatment of their patients and to apply their skills to the patients most in need of them.

Analysis of Variance↗

An interactive technique for the display of nucleic acid secondary structure.

The ability to visualize nucleic acid secondary structure has become quite important since the advent of computer prediction and biochemical techniques that depict such structures. Manually drawing the conformations can be quite time consuming and tedious. Thus, the ability to draw with the aid of a computer the secondary structure of nucleic acid molecules is quite advantageous. This paper describes an interactive algorithm that permits one to generate such drawings which may then be used for further analysis and/or publications.

Animals↗

Tongue extrusion as an aid to blind nasal intubation.

Blind nasal intubation often results in esophageal placement of the tube because reflex swallowing and supralaryngeal structures direct the tube posteriorly. Extrusion of the tongue, which inhibits swallowing and shifts the supralaryngeal structures anteriorly, facilitated blind placement of a nasotracheal tube in 14 of 16 critically ill patients. The technique avoids manipulation of the neck, the use of heavy sedation or anesthesia, and requires no specialized training or equipment.

Adult↗

Relation of facial expressions and activities: a study of attensity differences in events.

The role of experience in the perception of visual events was examined in a study of facial communications. It was hypothesized that the facial expressions manifested by actors as they performed various tasks would be specific to those tasks or reflective of the activities being performed. Consequently, the facial expressions themselves would provide information regarding the task performed, and this information would be more salient for viewers who were familiar with the tasks. Experienced viewers were the best perceivers, but the type of task performed significantly affected viewer's accuracy. A unitization measure recorded by viewers helped to pinpoint some of the reasons for the differential accuracy rates, while also speaking to the hypothesized differences in attensity which distinguished experienced from inexperienced viewers.

Communication↗