Search PubMed⌕ Search

Biomedical subjects

B A Rubin

Publications and source records attributed to B A Rubin.

At least 73 records · Page 4Linked to original sources
PubMed1966

Replication of adenovirus type 7 in monkey cells: a new determinant and its transfer to adenovirus type 2.

A strain of human adenovirus type 7, adapted to replication in green-monkey kidney cells, requires the interaction of two particles to initiate plaque formation in the simian cells. One particle is a true adenovirion. The second, apparently defective, consists of a genome carrying amonkey-adapting component in an adenovirus capsid; this genome does not express known SV40 determinants. The addition of human adenovirus type 7 that is not adapted enhances the titer and changesconditions for plaque formation by the adapted virus to a one-particle requirement. Addition of nonadapted human adenovirus type 2 as helper virus results in the transfer of the monkey-adaptingcomponent from adenovirus type 7 to adenovirus type 2. The population containing the adenovirus 2 transcapsidant then has the ability to replicate in simian cells.

Adenoviridae↗
PubMedDate not supplied

[Comparative study of the antiviral properties of histones of animal and plant origin].

The antiviral properties of histones of animal (thymus) and plant (French beans) origin were studied in plants and with a plant virus, tobacco mosaic virus (TMV). Histones of the thymus and French beans were shown to be able to inhibit TMV reproduction. The antiviral properties of histones were found to depend on their concentration, pH, and to be determined by the modes of their introduction into leaves. The manifestation of the antiviral properties of histones seems to require not only their direct contact with virus but also a certain exposure on the leaf. The similarities of antiviral protective mechanisms of plants and animals determined by substances of the protein nature are discussed.

Animals↗