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Biomedical subjects

B A Ross

Publications and source records attributed to B A Ross.

47 records · Page 3Linked to original sources
PubMed1972

Control of transcription of RNA rich in polyadenylic acid in human lymphocytes.

Rapidly labeled polyribosomal RNA rich in poly(A) has been isolated from cultures of highly purified human peripheral blood lymphocytes. Messenger RNA function for this RNA is suggested by its ability to direct [3H]Met-tRNA binding to ribosomes and incorporation of amino acids into protein in a cell-free preparation. Phytohemagglutinin and low concentrations of dibutyryl cAMP (40 nM) increase poly(A)-rich RNA synthesis 40% within 2 hr, and 100-300% by 12 hr; the percent poly(A) content and the size of the poly(A)-rich portion remain constant. Higher concentrations of dibutyryl cAMP (1 nM), which prevent morphological transformation of lymphocytes by phytohemagglutinin, inhibit synthesis of poly(A)-rich RNA in phytohemagglutinin-treated lymphocytes without damaging cells. Cortisol (0.1 mM), which also prevents lymphocyte transformation, inhibits poly(A)-rich RNA synthesis by 80%. Cycloheximide (5 micro/ml), which decreases protein synthesis by 90%, decreases poly(A)-rich RNA synthesis 80% in cells stimulated by phytohemagglutinin. These studies demonstrate that, as part of the early molecular events of their action, phytohemagglutinin and cortisol regulate transcription of adenylate-rich RNA in human lymphocytes, and that similar transcriptional effects can be produced by dibutyryl cAMP.

Adenine Nucleotides↗
PubMedDate not supplied

Milk of calcium in the breast: appearance on prone stereotactic imaging.

Microcalcifications discovered by mammography require careful analysis, occasionally leading to core biopsy to exclude associated breast cancer. We report unrecognized milk of calcium layering on small field of view prone digital stereotactic images. We illustrate important features on prone digital images attributed to milk of calcium which can exclude breast neoplasm, suggest this diagnosis, and prevent unnecessary biopsy.

Adult↗
PubMedDate not supplied

Use of a database for managing qualitative research data.

In this article, a process for handling text data in qualitative research projects by using existing word-processing and database programs is described. When qualitative data are managed using this method, the information is more readily available and the coding and organization of the data are enhanced. Furthermore, the narrative always remains intact regardless of how it is arranged or re-arranged, and there is a concomitant time savings and increased accuracy. The author hopes that this article will inspire some readers to explore additional methods and processes for computer-aided, nonstatistical data management. The study referred to in this article (Ross, 1991) was a qualitative research project which sought to find out how teaching faculty in nursing and education used computers in their professional work. Ajzen and Fishbein's (1980) Theory of Reasoned Action formed the theoretical basis for this work. This theory proposes that behavior, in this study the use of computers, is the result of intentions and that intentions are the result of attitudes and social norms. The study found that although computer use was sometimes the result of attitudes, more often it seemed to be the result of subjective (perceived) norms or intervening variables. Teaching faculty apparently did not initially make reasoned judgments about the computers or the programs they used, but chose to use whatever was required or available.

Data Collection↗