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Biomedical subjects

B A Peretz

Publications and source records attributed to B A Peretz.

At least 37 records · Page 2Linked to original sources

Retroperitoneal metastatic spread of malignant Brenner tumor.

It became evident that ovarian cancer spreads mainly by continuity to the adjacent pelvic organs. Retroperitoneal node metastases, especially in the absence of other forms of spread, when the neoplasm is confined to the ovary, is less well described. Recent literature stressed that different histological types of ovarian epithelial cancer can and do spread to the retroperitoneal lymphatics early in the course of the disease. In this report we present a patient with FIGO Ia malignant Brenner tumor in whom metastatic disease was found in retroperitoneal lymph nodes. To our knowledge, a similar observation has not been previously described. It should be concluded that selective biopsies of the retroperitoneal lymph nodes should be part of the staging laparotomy for any ovarian carcinoma.

Adult↗

An epidemic-like appearance of congenital cystic hygroma.

Five fetuses with cystic hyroma were diagnosed in our department during a period of 5 months. Four of them were identified by an ultrasonic examination. No common causative factor was found to explain the appearance of such a rare anomaly in 5 cases over a very short period of time.

Female↗

Gestational age assessment by the lens examination method in normal and pathological pregnancies.

The anterior vascular capsule of the lens was examined in 100 premature infants. It was found that the normal embryological process of gradual disappearance of the anterior vascular capsule between 27 and 34 weeks of gestation is not significantly influenced by maternal and fetal high risk factors, nor by maternal drug intake. It seems that lens examination could be regarded as a good method of gestational age estimation between the 27th and 34th week of gestation.

Female↗

Serotonin and the ovarian hyperstimulation syndrome.

Ovarian hyperstimulation syndrome was induced in rabbit by administration of human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG). In an attempt to establish whether serotonin plays a part in the induction of this syndrome, the hyperstimulated rabbits were divided into two groups and were administered known anti-serotonin drugs, cyproheptadine and methysergide, respectively. The group treated with cyproheptadine, a non-specific serotonin antagonist, exhibited significant acceleration in the regression of the syndrome. Methysergide, a specific serotonin antagonist, administered to the second group, neither prevented the occurrence of the syndrome nor accelerated its regression. The results of this work indicate that serotonin does not seem to be directly involved in the production of the ovarian hyperstimulation syndrome in rabbits.

Animals↗

Nonstress Test in standing and lying women.

The effect of the maternal postural position on the Nonstress Test (NST) was evaluated in 14 normal pregnancies at 38-40 weeks of gestation. Each women was studied for two periods of 30 min, each in the standing and left lateral recumbent positions. Comparing both positions no significant difference was found in the number of fetal movements and heart rate accelerations. The total surface area of accelerations (TSAA) was significantly larger in the standing position.

Female↗

Menstrual-cycle-dependent and -independent features of the human Fallopian tube fimbrial epithelium: an ultrastructural and cytochemical study.

Ultrastructural and cytochemical features of 100 specimens of human Fallopian tube fimbrial epithelium were studied to determine whether they were dependent on or independent of the ovarian hormones. Characteristics which were independent of hormonal control included the presence of alkaline phosphatase reaction product along the apical cell membrane of the secretory cell and its absence in the ciliary cell. Acid phosphatase reaction product was found in ciliary and secretory cell lysosomes in similar numbers and calcium deposits were observed in ciliary and secretory cell nuclei, nucleoli and cell membranes. On the other hand, characteristics dependent on stages of the cycle included the presence of mitochondrial-bound calcium during the preovulatory phase and its depletion during the periovulatory phase. The same sequence was noticed in the content of the large ciliary cell perinuclear globules, which displayed accumulations of glycogen and lipid in preovulatory phase and their depletion during the periovulatory phase. It seems that during the periovulatory phase the increased metabolic activity of the cells is accompanied by utilization of some of the material stored within the cells.

Alkaline Phosphatase↗

Pregnancy complicated by herpes zoster. A report of two cases and literature review.

Herpes zoster during pregnancy is rare, with only 13 reported cases. Although the prognosis is usually favorable, the disease can be associated with congenital malformations. We treated two pregnant women with herpes zoster at 25 and 31 weeks of gestation. The disease was diagnosed clinically and confirmed by serology and virus isolation. Both women delivered normal infants with normal development.

Adult↗

Ultrastructural localization of alkaline and acid phosphatases in the human fallopian tube epithelium during the menstrual cycle.

Ultrastructural and cytochemical methods were utilized to study the human Fallopian tube fimbrial epithelium during the different stages of the menstrual cycle. Alkaline phosphatase reaction product was located along the apical and lateral plasma membranes of the secretory cells only, regardless of the stage of the cycle. The ciliated cells were almost devoid of any reaction product at all stages of the cycle. Acid phosphatase reaction product depicted the lysosomes. These appeared as electron-dense bodies, of almost equal numbers in the ciliated and the secretory cells at all stages of the cycle. Thus the number of lysosomes did not vary appreciable during the different stages of the menstrual cycle. Many lipid droplets were found in both cells; these were rimmed by acid phosphatase reaction product, and some were partially enveloped by electron-dense bodies containing acid phosphatase deposits. Acid phosphatase deposits were also found on the inner face of Golgi vesicles.

Acid Phosphatase↗

Juxtanuclear globule of the human fimbrial epithelium ciliary cell: a histo- and cytochemical study.

Microbiopsies of human Fallopian tube fimbrial epithelium were obtained during routine gynecological operations, and during pregnancy while undergoing hysterectomy in the first trimester or cesarean section in the third trimester. Specimens were studied under light and electron microscopes utilizing histo- and cytochemical techniques. Large juxtanuclear globules were demonstrated in the ciliary cell at all stages of the cycle. During the proliferative phase, these globules contained large lipid droplets and glycogen rosettes. The content of the globules in the early luteal phase was mostly amorphous electron-lucid material which failed to stain with PAS, alcian blue and the Millon reaction. However, reaction products of acid phosphatase as well as calcium precipitate were scattered in them as discrete granules. The same type of globule was found in early pregnancy. During late luteal phase and late pregnancy, the content of the globule was once again composed of lipids and glycogen. It seems that lipid and glycogen accumulate during the preovulatory phase, while depletion and dispersion of these substances occur in the periovulatory phase, probably due to increased energy utilization. Late luteal phase revealed subsequent replenishment of these reserves, as was also revealed in late pregnancy.

Acid Phosphatase↗

Ultrastructural localization of calcium in human uterine tube epithelial cells.

Microbiopsies of 38 specimens of human Fallopian tube fimbrial epithelium obtained during hysterosalpingectomy operations were processed for electron microscopic observation. Calcium localization was demonstrated utilizing the pyroantimonate-osminium-tetroxide technique. Calcium deposits were consistently observed as scattered granules in the nuclei, nucleoli, and cell membranes of secretory and ciliary cells regardless of the stage of the menstrual cycle. On the other hand, mitochondrial-bound calcium was observed in the ciliary cells during the preovulatory phase, coinciding with relatively high estrogen levels, and was not found during the peri- and postovulatory phases of the menstrual cycle. It appears that there is cellular calcium which is relatively stable and is probably part of the structural components of the cells. The ciliary cell mitochondrial calcium appears to be more labile and is therefore available for mobilization and utilization in the metabolic processes associated with the periovulatory phase.

Adult↗

Human fallopian tube epithelium cytochemistry in the first and third trimesters of pregnancy.

The human Fallopian tube fimbrial epithelium was histo- and cytochemically studied in the first and third trimesters of pregnancy. In the first trimester morphometric measurements confirmed a decrease in cell size and a reduction in ciliary cell count. The ciliary cell population was surprisingly glycogen-poor, and some of the cell contained, among normal organelles, lipid accumulation, lamellated bodies and nuclei with slightly condensed chromatin. Some had defective cilia and basal bodies. Large globules, containing few lipid droplets and glycogen rosettes were demonstrated. The bulk of the globules, however, contained an unidentified electron-lucid substance, negative to PAS, Alcian blue, OsO4 and the Millon reactions, but positive to acid phosphatase reaction, the products of which appeared dispersed. The nonciliary cell population was heterogeneous; some appeared almost devoid of microvilli and had dilated RER and SER cisternae, lamellated bodies and condensed nuclear chromatin. In some cells a single centrally located cilium was noticed. Other nonciliary cells had extensive microvilli and appeared less atrophied. In the third trimester morphometric, as well as cytochemical methods indicated that the regressive process was beginning to reverse itself. Alkaline-phosphatase reaction products appeared along the apical and lateral membranes of the nonciliary cell. Acid-phosphatase reaction products depicted the lysosomes, present in both types of cells.

Acid Phosphatase↗