Biomedical subjects
Publications and source records attributed to B A Krugovov.
On the basis of studying the long-term results of treatment of 268 patients with a localized form of primary cutaneous melanoma, the prognostic value of the used methods of treatment, level of tumour invasion into the skin, sex and age of a patient, tumour localization, presence or absence of its ulceration was established.
UNLABELLED: Four patients with Sutton's disease (males--2, females--2, age--from 8 to 26 years) were observed for 2 to six years. Multiple lesions were found in 3, single--in 1 patients. LOCATION: skin of the back, extremities, neck, head. No case of malignization was noted; in two patients Sutton nevi disappeared completely spontaneously, but new growths appeared in other places. Though all cases had a benign nature alertness as to malignant degeneration should be observed.
A clinical investigation of the tolerance of a short-term (15-30 min) normobaric gaseous hypoxia caused by the inhalation of mixtures containing 7.4-8.2% O2 was conducted. Cerebral and liver hemodynamics, function of the cardiovascular system, some biochemical and hematological indicators were studied in 20 healthy volunteers and 18 cancer patients. It was noted that breathing with this mixture was worse tolerated than with that containing 10% O2, however no stable functional changes in the human body were observed. In the authors' opinion, the gaseous mixture containing 8% O2 can be used in radiation therapy of cancer patients for the protection of normal tissues.
The dynamics of immune indices in 38 patients with Hodgkin's disease, following splenectomy and radiation therapy is discussed. The early stage of the disease is found to involve changes in immune response which become more pronounced in the course of generalization of tumor process and development of intoxication symptoms. Correlations between the frequency of spleen and lymph nodes lesions below the diaphragm, histological pattern of tumor and decline in immunological vigor are shown. Also, indications for splenectomy are discussed.
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