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Biomedical subjects

B A Jagtman

Publications and source records attributed to B A Jagtman.

At least 19 recordsLinked to original sources
PubMed1999

[Latex glove allergy in dental practice].

Skin reactions due to the use of latex examination gloves occur frequently in dental practice. They consist of immediate type I allergy to natural latex protein, type IV delayed hypersensitivity to rubber additives and irritant dermatitis. Type I allergy to latex protein can cause contact urticaria, angioedema, rhinoconjunctivitis and asthma in the dentist, the dental assistant and also in the patient. Exceptionally, latex allergy can cause a life-threatening anaphylactic reaction. Cross reactions to tropical fruit can occur in the latex allergic patient. Type IV allergy causes allergic contact dermatitis. Rubber additives are also present in synthetic rubber. Glove advice for latex allergic patients are presented.

Anaphylaxis↗
PubMed1996

Methyldibromoglutaronitrile is an important contact allergen in The Netherlands.

From 15 May to 15 December 1994, 2943 patients suspected of having contact dermatitis (1955 women, 988 men) were patch tested with methyldibromoglutaronitrile 0.3%, 0.1% and 0.05% pet. 119 patients (4.0%; women 4.1%, men 3.8%) proved to be allergic. 71% of the reactions were considered to be relevant. In 2/3 of the patients, causative products were cosmetics, in 1/3 moistened toilet tissues. Testing with methyldibromoglutaronitrile at lower concentrations (0.05% and 0.1%) and with commercial allergens (Euxyl K 400 and methyldibromoglutaronitrile, both containing methyldibromoglutaronitrile 0.1%), resulted in a number of false-negative reactions. All preservatives in the European standard series had lower scores than the 4% positive reactions to methyldibromoglutaronitrile (formaldehyde 2.0%, MCI/MI (Kathon CG) 3.2%, parabens 1.0%, quaternium-15 1.3%). It is concluded that methyldibromoglutaronitrile (present in the commercial preservative Euxyl K 400) is an important contact allergen in the Netherlands in cosmetics and moistened toilet tissues. It should be added to cosmetics series and to proctological series. The optimal test concentration is unknow, but may be 0.3% pet. The concentration of 0.1% methyldibromoglutaronitrile in the currently available commercial allergens appears to be too low, resulting in a number of false-negative reactions.

Adolescent↗
PubMed1988

The allergens in cosmetics.

The ingredients responsible for allergy to cosmetics were determined in 119 patients suffering from cosmetic-related contact dermatitis. Most reactions (56.3%) were caused by skin care products, followed by nail cosmetics (13.4%), perfumes (8.4%), and hair cosmetics (5.9%). Preservatives were most frequently implicated (32.0%), followed by fragrances (26.5%) and emulsifiers (14.3%). By far the most important cosmetic allergen was Kathon CG, (a preservative system containing, as active ingredients, a mixture of methylisothiazolinone and methyl chloroisothiazolinone) reacting in 33 patients (27.7%). Other frequent causes of cosmetic-related contact allergic reactions were toluenesulfonamide/formaldehyde resin in nail hardener and/or nail lacquer (15 patients [12.6%]), and oleamidopropyl dimethylamine, an emulsifier in baby body lotion (13 patients [10.9%]).

Adolescent↗
PubMed1988

Contact allergy to diazolidinyl urea (Germall II).

4 cases of contact allergy to diazolidinyl urea (Germall II) in a "hypoallergenic" brand of cosmetics are described. 2 patients sensitized by these cosmetics were not allergic to formaldehyde. 2 other patients already sensitive to formaldehyde had exacerbations of dermatitis due to diazolidinyl urea. The following tentative conclusions were drawn. (i) Contact allergy to diazolidinyl urea may or may not be due to formaldehyde sensitivity. (ii) Patients allergic to formaldehyde may suffer contact allergic reactions from the use of cosmetics containing diazolidinyl urea. (iii) Patients sensitized to diazolidinyl urea may cross-react to imidazolidinyl urea and vice-versa. (iv) It is suggested that the sensitizing potential of diazolidinyl urea is greater than that of imidazolidinyl urea. (v) Aq. solutions may be preferable to pet. for patch testing with diazolidinyl urea.

Adult↗
PubMed1988

Cross-reaction pattern of the cationic emulsifier oleamidopropyl dimethylamine.

13 patients allergic to the cationic emulsifier oleamidopropyl dimethylamine were tested with a series of related amide-amine type surfactants in order to investigate its cross-reaction pattern. With 1 exception, all patients reacted to at least 4 of the test materials. Most reactions were observed to ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (11 patients, 85%); 9 patients (of 12 tested, 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. A certain pattern of cross-reactivity was recognised.

Adolescent↗
PubMed1987

Contact allergy to 4-isopropyl-dibenzoylmethane and 3-(4'-methylbenzylidene) camphor in the sunscreen Eusolex 8021.

10 cases of contact allergy from the sunscreen Eusolex 8021 are reported. 5 patients were sensitized to a lipstick, 4 to a sunscreen cream, and 1 reacted to several cosmetic creams. Of 9 patients tested with the 2 ingredients of Eusolex 8021, 5 proved to be allergic to both (chemically unrelated) constituents: 4-isopropyl-dibenzoylmethane and 3-(4'-methylbenzylidene) camphor; 4 were allergic to 4-isopropyl-dibenzoylmethane only. Contact allergy to this recently introduced broad spectrum sunscreen may not be rare. The relevant literature is reviewed.

Adult↗
PubMed1986

Contact allergy to preservatives--II.

To determine whether the prevalence of allergic reactions to certain preservatives warrants their inclusion in a routine series for patch testing, a tray of 14 preservatives was tested in 501 consecutive suspected contact dermatitis patients. More than 1% positive reactions were found with DMDM hydantoin, Kathon CG, and alkyl trimethyl ammonium chloride only. The concentration of alkyl trimethyl ammonium chloride (0.1% aqua) was considered too high. Of 6 patients reacting to the formaldehyde releaser DMDM hydantoin, 4 were positive to formaldehyde. Kathon CG may be an important allergen in the Netherlands, and it is worthwhile for dermatologists there to add it to the standard test series. The recent inclusion of quaternium-15 in the ICDRG standard series appears to be of little value to them.

Cross-Sectional Studies↗