Value of gas exchange analysis in heart disease.
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Biomedical subjects
Publications and source records attributed to B A Clark.
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The Nursing Research Committee of a community hospital describes the difficulties and unexpected pitfalls encountered during an attempt to conduct "research by committee." The steps of the process, from initial development of a research question through research design and implementation and termination of the project, are related. A retrospective analysis of the difficulties encountered serves as a basis for recommendations to others who might consider research by committee. Although a valid means for conducting research, the experiences of this committee indicate how forces, in their control and beyond their control, might influence completion of a project.
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Koilocytosis was studied in eight cases of dysplasia and reactive atypia with conventional transmission electron microscopy. The ultrastructural features were compared to the process of maturation of normal cervical epithelium. Koilocytosis was observed as abnormal karyopyknosis as represented by irregular nuclei, coarse chromatin clumping, the less dense ellipsoid perinuclear zone, and the increased tonofilament bundles in the outer zone of the cytoplasm accentuating the margin of the perinuclear zone of the cells.