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Biomedical subjects

B A Bron

Publications and source records attributed to B A Bron.

7 recordsLinked to original sources
PubMed1985

Evaluation of pirenzepine on gastric acidity in healthy volunteers using ambulatory 24 hour intragastric pH-monitoring.

The effect of pirenzepine on 24 hour intragastric acidity was studied in 10 healthy volunteers using ambulatory 24 hour intragastric pH-monitoring in a double blind crossover study. Tests were performed on the seventh day of ingestion of either placebo, 75 mg pirenzepine or 150 mg pirenzepine per day. The drugs were given at two doses at 8.30 am and 8.30 pm. Mean nocturnal hydrogen ion activity during placebo treatment was 68 mmol/l +/- 9 SEM and was reduced by 75 mg (26%, p less than 0.01) and 150 mg of pirenzepine (36%, p less than 0.01), respectively. Mean diurnal hydrogen ion activity was 32 mmol/l +/- 6 SEM and was not significantly reduced (p greater than 0.1) by either dose of pirenzepine (4% and 12% respectively). Thus, the effect of pirenzepine on intragastric acidity is small, even with high doses of the drug, and becomes apparent only during the night.

Adult↗
PubMed1983

Metabolic effects of dietary fiber from dehulled soybeans in humans.

The normal diet of six healthy volunteers was supplemented by 21 g of dietary fiber from two different soybean seed fiber preparations, either a nonpurified and never-dried soya pulp A (39% dietary fiber) or a purified soya fiber B (79%), for 3 wk each. Mean daily fecal wet weight was increased by 19 and 38% in the fiber periods A and B as compared to a 2-wk control period (p less than 0.05). Stool frequency and transit time remained unchanged. Fecal fiber increased by 52% only during period B. Fecal calcium, magnesium, and iron were increased (p less than 0.05), mainly after higher intakes during both fiber periods. Excretion of neutral steroids remained unchanged, but their concentration was lowered (p less than 0.05). A 21% increase of fecal bile acids by fiber A was specifically due to deoxycholic acid (+32%, p less than 0.01). Oral glucose tolerance was slightly improved after period B. Neither fiber changed serum triglycerides, but fiber B increased low-density lipoprotein-cholesterol by 19% (p less than 0.01) and low-density lipoprotein-phospholipids by 16% (p less than 0.05). The ratio high-density/low-density lipoprotein-cholesterol, however, did not change significantly. Thus, dietary fibers from soybean do not seem to contribute to the hypocholesterolemic effect of soya. The results of this study also demonstrate that two apparently similar dietary fibers, coming from a single source, can exert distinctly different metabolic effects.

Adult↗
PubMed1977

Phlegmonous gastritis diagnosed by endoscopic snare biopsy.

A case of phlegmonous gastritis, diagnosed for the first time without laparotomy and with spontaneous recovery, is described. The only procedure allowing nonsurgical diagnosis of this disease is endoscopic snare ("jumbo") biopsy of the giant folds in the diseased parts of the stomach. Snare biopsy includes submucosal tissue which is the main site of histological changes in phlegmonous gastritis.

Adolescent↗
PubMed1976

Esophageal function in progressive systemic sclerosis.

A prospective study was performed in 13 consecutive patients with systemic progressive sclerosis (PSS). For the diagnosis of impaired esophageal peristalsis cineradiography and manometry are equally useful. Esophageal suction biopsy allows the diagnosis of esophagitis but not of scleroderma. Mild to severe esophageal involvement was observed in 12 patients. In only one patient the esophagus was virtually normal. Dysfunction of the esophageal body may occur early in the course of the disease while incompetence of the lower esophageal sphincter is observed on an average after 7 to 8 years. Both impairment of peristalsis and pressure of the lower esophageal sphincter may lead to delayed esophageal clearance. Relaxation of LES is normal even in the absence of primary peristalsis. Extensive esophageal damage including severe gastroesophageal reflux may be present in the absence of esophageal symptoms.

Adult↗
PubMed1976

Gastro-oesophageal reflux disease: correlation of subjective symptoms with 7 objective oesophageal function tests.

Seven tests which have been recommended for the diagnosis of gastro-esophageal reflux were applied in 24 healthy controls and in 48 patients with symptoms of reflux disease. The correlation coefficient of test results with the subjective symptoms of the patient decreased in the following order: 1) acid clearance from the distal esophagus (r = 0.558, p less than 0.001), 2) suction biopsy 5 cm above lower esophageal sphincter (LES) with evaluation of granulocytic infiltrates (r = 0.450, p less 0.001), 3) radiological demonstration of hiatal hernia (r = 0.435, p less than 0.001), 4) reflux provocation test (r = 359, p less than 0.01), 5) modified Bernstein test (r = 0.322, p less than 0.01), 6) acid relux test (r = 0.252, p less than 0.05), 7) resting pressure of LES (r = 0.246, p less than 0.05). Results of the Maudsley Personality Inventory were not correlated with subjective symptoms (r = 0.188, p greater than 0.1). By stepwise multiple regression analysis it was shown that optimal diagnosis of reflux is achieved by combination the following 4 procedures: 1) acid clearance, 2) modified Bernstein test, 3) suction biopsy, and 4) radiology.

Biopsy↗