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Biomedical subjects

Augusto Sarmiento

Publications and source records attributed to Augusto Sarmiento.

18 recordsLinked to original sources
PubMed2005

Repair of steps and gaps in articular fracture models.

To examine the healing of surface defects in articular fractures, gaps measuring 0.5 mm wide and 2 mm deep were created in 0.5-mm coronal step-offs on the medial femoral condyles of 16 rabbits, and identical gaps without step-offs were created in another set of 13 rabbits. Evaluation of repair was done 6, 12, and 24 weeks postoperatively. Histologically, subchondral bone restoration of gaps in step-offs was complete by 24 weeks, whereas restoration was incomplete in most gap-only lesions. Bone density measured by peripheral quantitative computed tomography was normal in gaps in step-offs by 24 weeks, but values were less than in controls in the gap-only group. A moderate degree of degeneration was detected only at the high sides of step-off + gap lesions. The joint surface was restored by fibrous cartilage that showed gradually improving maturity in all defects, however, real integration with adjacent original cartilage did not occur. Immunohistologic examination showed decreasing collagen Type I and increasing Type II staining intensity in repair tissue of both types of lesions. These observations suggest that minor surface gaps and steps of articular fractures may regenerate without inducing severe early joint degeneration. However, certain repair features make the long-term outcome of these defects uncertain.

Animals↗
PubMed2005

Thromboembolic disease prophylaxis in total hip arthroplasty.

UNLABELLED: We sought to determine if using aspirin and exercise as prophylaxis against thromboembolic disease in patients having total hip arthroplasties would provide results as effective as or better than those reported in the literature using other chemical agents. One thousand eight hundred thirty-five total hip arthroplasties were done in 1585 patients using a posterior approach. Surgery was done with the patient under general anesthesia in 459 instances and regional anesthesia in 1376 instances. Graduated elastic stockings were used in 1117 instances and intermittent compression stockings were used in 718 instances. Passive exercises of the major joints of the operated extremity were done intraoperatively, and active exercises were done postoperatively. Patients received a suppository containing 10 grains of aspirin immediately after surgery and 325 mg twice a day for the length of their hospitalization. Fatal pulmonary embolism developed after two (0.10%) surgical procedures. Nonfatal pulmonary embolisms were diagnosed in 17 (0.9%) patients, and deep venous thrombosis was diagnosed in 17 (0.9%) patients. The low incidence of thromboembolic complications recorded in this series suggests that our postoperative protocol, including 325 mg of aspirin twice a day during hospitalization and exercise, is an effective and inexpensive method of prophylaxis after total hip arthroplasty. LEVEL OF EVIDENCE: Therapeutic study, Level IV (case series--no, or historical control group). See the Guidelines for Authors for a complete description of levels of evidence.

Arthroplasty, Replacement, Hip↗
PubMed2004

450 closed fractures of the distal third of the tibia treated with a functional brace.

Four hundred fifty closed fractures of the distal third of the tibial diaphysis, treated with a functional brace, are the subject of this study. Four (0.9%) of the fractures resulted in nonunion. The average healing time was 16.6 +/- 5.6 weeks, with a range from 10-40 weeks. The average final shortening was 5.1 +/- 4.8 mm with a range from 0-25 mm. Four hundred twenty four (94.2%) fractures healed with < 12 mm shortening. Initial shortening at the time of injury essentially was unchanged, from 4.4 +/- 4.5 mm to 4.4 +/- 3.9 mm final shortening. Axially unstable closed tibial fractures do not shorten beyond the initial shortening. Four-hundred five fractures (90.0%) healed with less than 8 degrees angular deformity in either the frontal or sagittal planes, and 302 (67.1%) healed with less than 5 degrees deformity in any plane. Overall, 391 fractures (87%) healed with shortening less than 12 mm and angulation in any plane less than 8 degrees . These degrees of angular deformity and shortening seem to compare favorably with those reported by other investigators using intramedullary nails. It seems that functional bracing is an effective method of treatment of a selected group of tibial fractures.

Adolescent↗
PubMed2004

A functional below-the-knee cast for tibial fractures. 1967.

An experimental method of treating tibial fractures with use of the below-the-knee total-contact weight-bearing cast is discussed. The success of this method appears to depend on the careful application and molding of plaster to the fractured leg after the swelling has been reduced to a minimum and a closed reduction has been obtained. Good alignment is essential, but slight shortening or overriding of fragments can be accepted with the expectation that little or no increase in the amount of shortening will occur. The results obtained indicate that this type of cast not only holds reduction well but also permits healing of tibial fractures in a relatively short period of time. The maintenance of the limb in a near physiological condition throughout the entire reparative process is offered as an explanation for rapid healing. Treatment of tibial fractures by this method offers the advantages of retaining functional activity of the extremity during healing and eliminating the need for extensive rehabilitation of the knee and thigh muscles after healing has occurred.

Casts, Surgical↗
PubMed2003

Long-term radiographic changes in cemented total hip arthroplasty with six designs of femoral components.

Measurements were made from annual follow-up radiographs, obtained over 27.6 years, of 860 cemented total hip arthroplasties implanted by one surgeon. Femoral components were made of stainless steel or titanium alloy, were non-modular, and were all fixed with cement, and acetabular cups were all-polyethylene and were fixed with cement. Radiographic outcome was correlated with the shape and material of the femoral component. Specifically, throughout the follow-up, stems made of titanium alloy were at greater risk of developing bone-cement radiolucent lines than those made of stainless steel, the difference ranging from approximately 10-50 percent at 2-10 years of follow-up. Similarly, titanium alloy stems were at greater risk of developing endosteal scalloping, indicating osteolytic lesions. Among the stainless steel Charnley cobra and straight-narrow Charnley stems, none developed cement fracture, only one became radiographically loose and one developed endosteal scalloping. The differences in the risk of developing radiolucent lines, cement fracture and progressive loosening among these stems were correlated with the relative rigidity of the femoral stems, and were generally consistent with the predictions made heretofore using finite element models, although differences in stem surface finish and femoral ball size and material could have also influenced the results.

Aged↗
PubMed2003

The relationship between orthopaedics and industry must be reformed.

It is well-known that the long-standing relationship between orthopaedics and industry has benefited both parties. However, strong evidence indicates that the relationship is no longer a balanced one. Through a very effective stratagem, industry has used its enormous marketing power to a degree where the education of the orthopaedists now is, to a great degree, under its control and structured to satisfy its marketing needs. Orthopaedics' dependency on industry's support has resulted in our profession gradually abandoning its traditional values and ethical principles, and adopting those of the business community. This change is not in the best interest of medicine. The orthopaedic community, although striving to maintain a mutually productive relationship with industry, should forbid any intrusion into our autonomy in the areas of education and research.

Education, Medical, Continuing↗
PubMed2003

Closed fractures of the proximal tibia treated with a functional brace.

It generally is agreed that fractures of the proximal tibia, when treated with intramedullary nails, are more likely to present technical difficulties and to be associated with an increased rate of complications. This study reports on 108 closed fractures located in the proximal third of the tibia that were treated with functional braces. Nonunion occurred in 2.7% of the patients; the final displacement and shortening averaged 20% and 3.5 mm, respectively. Eighty-eight percent of the fractures healed with less than 6 degrees of angular deformity. It seems that functional braces for closed fractures of the tibia, located in its proximal third, are a viable therapeutic approach that offers satisfactory clinical and radiographic results in a high percentage of instances.

Adolescent↗
PubMed2002

Functional bracing in the treatment of delayed union and nonunion of the tibia.

We treated 16 delayed unions and 57 nonunions of the tibial diaphysis with a below-the-knee functional brace. In 48 cases, bracing was preceded by fibular ostectomy, and ten patients had an additional bone graft. We were able to follow 67 patients, of whom six (8.7%) failed to respond to treatment. In patients with nonunion, bony healing occurred with a median of 4 months. There was no difference in the speed of healing according to the level of the defect. Shortening of the limb following ostectomy of the fibula had a mean of 3 mm in the delayed-union group and 5 mm in the nonunion group.

Adolescent↗
PubMed2002

Diaphyseal humeral fractures: treatment options.

All of the current modalities have a place in the treatment of diaphyseal humeral fractures. Functional bracing renders a high rate of union and seems to be a safe method of treatment for most closed fractures. Type II and III open fractures seem to respond best to plate fixation or external fixation, particularly when there are associated neural or vascular pathologic findings. Patients with polytrauma who are unable to walk are also best treated with plate fixation. Plate fixation is also the best method of treatment when adequate alignment cannot be obtained with nonsurgical methods. Intramedullary nailing remains controversial because its complication rate is higher than that associated with either plate fixation or functional bracing. None of the treatments described is a panacea, and complications may occur with each one of them. An appropriate appreciation of the biologic response to the three modalities; an understanding of the indications, contraindications, and possible complications of the treatments; and a mastery of the techniques of application are essential for the attainment of satisfactory clinical results.

Biomechanical Phenomena↗