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Biomedical subjects

Atsuo Murata

Publications and source records attributed to Atsuo Murata.

At least 37 records · Page 2Linked to original sources
PubMed2004

[Simple quantitation of arsenic by energy dispersive fluorescence X-ray spectrometer using Reinsch's test].

We examined the clinical usefulness of the Reinsch's test for the detection of the small amounts of the heavy metals such as arsenic and mercury using the fluorescence X-ray spectrometry. We tried t o measure various kinds of biological samples, including serum, urine, and gastric contents using this method. 0.4 ml or 1 ml of hydrochloric acid were added to 2 ml of serum or 6 ml urine and gastric content, respectively, and a copper plate (5.0x 0.8 cm) was immersed into this solution. The mixture heated at 90 degrees C by a heating block for 30 minutes. After heating, the copper plate was washed with water and dried. The copper arsenide that stuck to the copper plate due to Reinsch's test dissolved by methanol/ammonia (8:2) solution at 60 degrees C for 15 minutes. A drop gave the solution to a filter paper fluorescence X-ray analysis and completely dried the filter paper, and applied to the fluorescence X-ray spectrometer. As a result, this method showed about 20 times high sensitivity in comparison with the measurement with condition of solution. The minimal detectable limits of rsenic was 0.4 ppm in serum and were 0.2 ppm in rine and gastric content. The calibration curve could be made for 0.5 to 50 ppm. It will take about 90 min for the measurement using this method for the detection of arsenic in biological samples. We showed the usefulness of the Reinsch's test using the fluorescence X-ray spectrometry in the clinical toxicology.

Acute Disease↗
PubMed2003

Predictors of death in patients with life-threatening pelvic hemorrhage after successful transcatheter arterial embolization.

OBJECTIVE: The purpose of this study was to determine predictors of death in patients with pelvic fracture whose pelvic arterial hemorrhage is controlled successfully by transcatheter arterial embolization (TAE). METHODS: From January 1996 to December 2000, 61 patients with a pelvic fracture who had pelvic arterial hemorrhage were treated at our Level I trauma center according to a protocol that assigns a high priority to diagnostic and therapeutic angiography within the algorithm. Angiography is performed before laparotomy in patients with hemoperitoneum, who can be stabilized by fluid resuscitation, and otherwise afterward. External fixation was performed immediately after TAE in the angiography suite. Predictors of outcome were determined retrospectively by univariate and multivariate analysis using anatomic and physiologic parameters. RESULTS: Forty-eight patients survived and 13 died. TAE successfully controlled pelvic arterial hemorrhage in all patients. Predictors of death included posterior pelvic arterial injury and an elevated Acute Physiology and Chronic Health Evaluation II score (odds ratio, 15.6 and 23.9, respectively). Need for fluid requirements to achieve hemodynamic stability were higher in nonsurvivors than in survivors. Outcome did not correlate with the type of fracture or the Injury Severity Score. CONCLUSION: Application of angiography as a therapeutic intervention in patients with pelvic arterial bleeding may reduce the need for surgery, thereby avoiding or minimizing this additional trauma.

APACHE↗
PubMed2003

Granulocyte colony-stimulating factor as the expecting sword for the treatment of severe sepsis.

Granulocyte colony-stimulating factor is a potent stimulator for neutrophils in the circulation as well as those progenitors to be increased and be grown in the bone marrow. Recombinant forms of this colony-stimulating factor, therefore, are widely using in the various kinds of clinical fields such as for the treatment of bone marrow suppression after cancer chemotherapy and for the treatment of myelodysplastic disorders. One of the physiological function of granulocyte colony-stimulating factor is to activate neutrophils enough to fight against invaded microbes and others, thus it is hoped to be used for the treatment of various kinds of infectious diseases even while the host has a normal number of circulating neutrophils and normal bone marrow. The future possible clinical usage of granulocyte colony-stimulating factor as for the immunomodulation against various kinds of insults to the human is reviewed.

Adjuvants, Immunologic↗
PubMed2003

[Postgraduate trauma education for surgeon--from the veiwpoint of trauma and emergency physicians].

A recent important topic in the field of trauma care is the elimination of "preventable death." Since patients' satisfactory prognosis and good recovery mainly depend upon the success of the initial evaluation and care, the responsibility of physicians who first come into contact with trauma patients in the emergency room is especially heavy. Many general surgeons examine trauma patients, although, unfortunately they have few opportunities for training in how to deal with those patients in the present educational program. Traumatology should be one of the most important areas of surgery, and therefore this paper emphasizes that every surgeon needs to be educated and trained in an adequate curriculum of trauma care. The Japanese Association for Acute Medicine could help by offering the Japan Advanced Trauma Evaluation and Care (JATEC) training program. JATEC proposes standardized guidelines as well as a nationwide the educational program for trauma management.

Education, Medical, Graduate↗