Biomedical subjects

Antonio Escobar

Publications and source records attributed to Antonio Escobar.

12 recordsLinked to original sources

PubMed2006

Association between inflammation, lipid and hemostatic factors in patients with stable angina.

INTRODUCTION: Dyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications. Moreover, inflammation has also been shown to play an important role in the pathophysiology of atherosclerosis. Our objective was to determine the association between inflammation, lipids and thrombosis in a group of patients with stable angina. PATIENTS AND METHODS: 295 patients (217 males and 78 females) with a mean age of 65.69+/-11.24 years. Levels of C-reactive protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), apolipoproteins A1 and B100, fibrinogen and D-dimer were determined for each. RESULTS: Arithmetic and geometric means of C-reactive protein in the sample were 10.7 and 1.4 mg/l, respectively. Distributing the sample by quartiles of C-reactive protein, we found a positive correlation between C-reactive protein, fibrinogen and D-dimer levels (p<0.000), and an inverse correlation for HDL cholesterol and apolipoprotein A1 (p<0.000). In multivariate analysis, fibrinogen (p<0.000) and D-dimer (p<0.01) levels were independently associated with high levels of C-reactive protein. Of the lipid factors, only apolipoprotein A1 (p<0.000) was independently and inversely associated with high levels of C-reactive protein. CONCLUSIONS: These data confirm the association between prothrombotic and inflammatory states and suggest the anti-inflammatory effect of apolipoprotein A1.

Aged↗

PubMed2006

Predictors of patient satisfaction with hospital health care.

BACKGROUND: We used a validated inpatient satisfaction questionnaire to evaluate the health care received by patients admitted to several hospitals. This questionnaire was factored into distinct domains, creating a score for each to assist in the analysis. We evaluated possible predictors of patient satisfaction in relation to socio-demographic variables, history of admission, and survey logistics. METHODS: Cross-sectional study of patients discharged from four acute care general hospitals. Random sample of 650 discharged patients from the medical and surgical wards of each hospital during February and March 2002. A total of 1,910 patients responded to the questionnaire (73.5%). Patient satisfaction was measured by a validated questionnaire with six domains: information, human care, comfort, visiting, intimacy, and cleanliness. Each domain was scored from 0 to 100, with higher scores indicating higher levels of patient satisfaction. RESULTS: In the univariate analysis, age was related to all domains except visiting; gender to comfort, visiting, and intimacy; level of education to comfort and cleanliness; marital status to information, human care, intimacy, and cleanliness; length of hospital stay to visiting and cleanliness, and previous admissions to human care, comfort, and cleanliness. The timing of the response to the mailing and who completed the questionnaire were related to all variables except visiting and cleanliness. Multivariate analysis confirmed in most cases the previous findings and added additional correlations for level of education (visiting and intimacy) and marital status (comfort and visiting). CONCLUSION: These results confirm the varying importance of some socio-demographic variables and length of stay, previous admission, the timing of response to the questionnaire, and who completed the questionnaire on some aspects of patient satisfaction after hospitalization. All these variables should be considered when evaluating patient satisfaction.

Adult↗

PubMed2006

Development of appropriateness explicit criteria for cataract extraction by phacoemulsification.

BACKGROUND: Consensus development techniques were used in the late 1980s to create explicit criteria for the appropriateness of cataract extraction. We developed a new appropriateness of indications tool for cataract following the RAND method. We tested the validity of our panel results. METHODS: Criteria were developed using a modified Delphi panel judgment process. A panel of 12 ophthalmologists was assembled. Ratings were analyzed regarding the level of agreement among panelists. We studied the influence of all variables on the final panel score using linear and logistic regression models. The explicit criteria developed were summarized by classification and regression tree analysis. RESULTS: Of the 765 indications evaluated by the main panel in the second round, 32.9% were found appropriate, 30.1% uncertain, and 37% inappropriate. Agreement was found in 53% of the indications and disagreement in 0.9%. Seven variables were considered to create the indications and divided into three groups: simple cataract, with diabetic retinopathy, or with other ocular pathologies. The preoperative visual acuity in the cataractous eye and visual function were the variables that best explained the panel scoring. The panel results were synthesized and presented in three decision trees. Misclassification error in the decision trees, as compared with the panel original criteria, was 5.3%. CONCLUSION: The parameters tested showed acceptable validity for an evaluation tool. These results support the use of this indication algorithm as a screening tool for assessing the appropriateness of cataract extraction in field studies and for the development of practice guidelines.

Activities of Daily Living↗

PubMed2006

Explicit criteria for prioritization of cataract surgery.

BACKGROUND: Consensus techniques have been used previously to create explicit criteria to prioritize cataract extraction; however, the appropriateness of the intervention was not included explicitly in previous studies. We developed a prioritization tool for cataract extraction according to the RAND method. METHODS: Criteria were developed using a modified Delphi panel judgment process. A panel of 11 ophthalmologists was assembled. Ratings were analyzed regarding the level of agreement among panelists. We studied the effect of all variables on the final panel score using general linear and logistic regression models. Priority scoring systems were developed by means of optimal scaling and general linear models. The explicit criteria developed were summarized by means of regression tree analysis. RESULTS: Eight variables were considered to create the indications. Of the 310 indications that the panel evaluated, 22.6% were considered high priority, 52.3% intermediate priority, and 25.2% low priority. Agreement was reached for 31.9% of the indications and disagreement for 0.3%. Logistic regression and general linear models showed that the preoperative visual acuity of the cataractous eye, visual function, and anticipated visual acuity postoperatively were the most influential variables. Alternative and simple scoring systems were obtained by optimal scaling and general linear models where the previous variables were also the most important. The decision tree also shows the importance of the previous variables and the appropriateness of the intervention. CONCLUSION: Our results showed acceptable validity as an evaluation and management tool for prioritizing cataract extraction. It also provides easy algorithms for use in clinical practice.

Activities of Daily Living↗

PubMed2006

Health-related quality of life and appropriateness of knee or hip joint replacement.

BACKGROUND: We studied the association between explicit appropriateness criteria for total hip joint replacement (THR) and total knee replacement (TKR) with changes in health-related quality of life of patients undergoing these procedures. METHODS: Prospective observational study of 1576 consecutive patients with diagnoses of osteoarthritis on waiting lists to undergo THR or TKR. Explicit appropriateness criteria using the RAND appropriateness method were applied. Patients completed 2 questionnaires that measured health-related quality of life, the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), before the procedure and 6 months afterward. RESULTS: Patients who were considered appropriate candidates for these procedures had greater improvements than those who were considered inappropriate candidates in all 3 WOMAC domains (pain, functional limitation, and stiffness; THR: 43.0, 40.6, and 40.4 vs 14.7, 19.1, and 15.9; TKR: 34.9, 32.5, and 30.2 vs 23.2, 18.9, and 17.1; P<.001 for all comparisons). Patients who underwent THR and were judged to be appropriate candidates had greater improvements in the physical function, role-physical, bodily pain, and social function domains of the SF-36 than those judged to be inappropriate candidates (34.4, 35.1, 33.1, and 26.6 vs 19.6, 9.2, 5.7, and 7.0; P = .04, P = .03, P < .001, and P < .001, respectively). Appropriate candidates for TKR demonstrated greater improvement in the social function domain of the SF-36 after the procedure than those deemed inappropriate candidates (19.9 vs 7.9; P = .004) but not in the other domains of functional status. CONCLUSIONS: These results suggest a direct relationship between explicit appropriateness criteria and better health-related quality-of-life outcomes after THR and TKR surgery. Our results support the use of these criteria for clinical guidelines or evaluation purposes.

Activities of Daily Living↗

PubMed2006

[Development and outcomes of the surgical management of multinodular goiter].

OBJECTIVES: The aims of this study were to: 1. Define our criteria and the results obtained in the surgical management of multinodular goiter (MNG); 2. Compare the results of partial thyroidectomies with those of total thyroidectomies; 3. Determine the incidence of "hidden" carcinomas diagnosed as MNG; 4. Define the most suitable treatment of MNG. MATERIAL AND METHODS: We performed a retrospective study (1999-2005) of 190 patients with MNG. Clinical characteristics, the diagnostic procedures used, surgical indications, the strategy employed, and biopsy results were analyzed. Overall morbidity and mortality were evaluated and statistical comparison of the morbidity-mortality rate between partial and total thyroidectomies was performed. RESULTS: Depending on the patients, diagnostic procedures consisted of ultrasonography, gammagraphy, computed tomography, and fine-needle aspiration (FNA). Surgical indication was established by compressive syndrome, endothoracic prolongation, rapid growth, suspected malignancy, nodular hyperthyroidism, the endocrinologist's criteria, and the patient's wishes. The surgical strategy showed a change in favor of radical surgery. The most common histologic diagnosis was nodular hyperplasia, but 16 carcinomas were "hidden" under a diagnosis of MNG (8.5%). There was no mortality. Morbidity, however, did exist, with the poorest results, showing statistically significant differences, occurring in total thyroidectomies. CONCLUSIONS: 1. Ultrasonography and FNA were routinely used for diagnosis. Surgical treatment tended to be radical. We believe that identification of recurrences and parathyroid disease is mandatory; 2. Morbidity was greater with total thyroidectomy; 3. Of patients who underwent surgery for MNG, 8.5% had a hidden thyroid carcinoma; 4. With certain limitations, total thyroidectomy is the most suitable therapy.

Adult↗

PubMed2005

Development and validation of an in-patient satisfaction questionnaire.

OBJECTIVE: To develop a psychometrically sound, hospital patient satisfaction questionnaire to be administered to patients discharged from medical and surgical services. DESIGN: Cross-sectional survey in Spanish. SETTING: Four acute care general hospitals of the Basque Health Service. STUDY PARTICIPANTS: Random samples of 650 discharged patients from each hospital during February and March 2002. A total of 1910 patients responded to the questionnaire (73.5%). MAIN OUTCOME MEASURES: Overall perceived quality of health care and perceived health improvement. RESULTS: No sociodemographic differences were found between respondents and non-respondents. Six dimensions were identified from the factor analysis, explaining 50% of the variance. All items, except two, revealed loadings above 0.4. Cronbach's alpha exceeded 0.7 for all dimensions, except privacy. Comfort was the dimension with the lowest level of patient satisfaction, whereas privacy was the most satisfactory. The interscale correlations never exceeded the internal consistency of each scale. The analysis of the dimensions with two items of global assessment showed a positive correlation. CONCLUSIONS: The results obtained from the development and validation of the questionnaire provide evidence of its psychometric properties, although it would be useful to carry out further analyses to assess time-based properties of reliability. We found a positive relation between the degree of patient satisfaction and overall evaluation of the quality of health care, providing evidence of the ability of the questionnaire to correlate with other concepts. The in-patient satisfaction questionnaire could become a useful instrument in quality-of-care assessment.

Cross-Sectional Studies↗

PubMed2005

Appropriateness of total hip joint replacement.

OBJECTIVE: To evaluate the appropriateness of the use of total hip joint replacements. DESIGN: Observational study of consecutive patients with a diagnosis of hip osteoarthritis and who had undergone total hip arthroplasty over a 1-year period from seven hospitals. MAIN MEASURES: The appropriateness of the use of hip replacement was judged by explicit criteria developed by a panel of experts using RAND methodology. The length of hospital stay during the admission and complications were recorded 6 months post-operatively. Patients were also surveyed 6 months after discharge to determine whether they believed they had recovered or their satisfaction with the intervention. Appropriateness results of this study were compared with a previous study performed with the same criteria 4 years previously. RESULTS: In total, 784 patients participated in the study. Indications for surgery were considered necessary in 52.2% of cases, appropriate in 21.3%, uncertain in 21.4%, and inappropriate in 5.1%. Differences were found in the rates of appropriateness exclusively from one hospital. At 6 months after discharge, differences between centres were found for the proportion of patients that reported they had recovered from surgery (range 57.7-24.8%) and in the length of hospital stay during admission (range 10-16 days). Improvement in the appropriateness rates were found for all participant hospitals during both periods. CONCLUSIONS: We identified a low percentage of inappropriate indications and differences in some outcomes between centres. Compared with previously, there has been improvement in the use of this technique, although both periods are not methodologically comparable.

Aged↗

PubMed2003

[A randomized clinical trial to compare the effectiveness of indinavir, ritonavir and saquinavir].

BACKGROUND AND OBJECTIVE: HIV protease inhibitors (PI) were licensed without a direct evidence of their relative efficacy. PATIENTS AND METHOD: 137 patients attending our clinics between November 1997 and March 1998, to whom treatment with a PI was recommended, were randomized to receive indinavir (IDV), saquinavir (SQV) or ritonavir (RTV). Main outcome variables were one-year mean changes in HIV-RNA plasma concentrations and CD4 cells counts and proportion of patients with HIV viral load below level of detection. RESULTS: Mean HIV viral load reductions were 0.95 for SQV, 0.72 for IDV and 0.65 for RTV (p = 0.44), equaling losses and changes to failures. In a standard intent-to-treat analysis, mean changes in viral load were 1.16, 1.01 and 1.50 (p = 0.21), respectively. The proportion of patients with undetectable viral load was 50%, with no differences between treatment arms. CONCLUSIONS: No differences were observed in the effectiveness of SQV, IDV and RTV.

Adult↗

PubMed2003

Development of explicit criteria for total knee replacement.

OBJECTIVES: To develop and test an appropriateness of indications tool for total knee replacement (TKR) in patients with osteoarthritis. METHODS: Criteria were developed using a modified Delphi panel judgment. Another panel rated the same indications, and the results were compared with the main panel. Test-retest of the main panel was performed. Regression models were used to assess the contribution of each algorithm variable. A classification tree was developed. RESULTS: The procedure was considered appropriate in 167 (26.8%) scenarios, and there was agreement on 112 (67.1%) of them. When the rates of the main panel were compared with those of a second panel, the result was a kappa statistic of 0.75. The test-retest kappa for the main panel was 0.78. Neither in the first case nor in the second was there an instance in which a scenario classified as appropriate shifted to inappropriate or vice versa. The regression models showed that symptomatology and radiology were the variables that explained most of the variability of appropriateness as determined by panelists. In the classification tree performed, the probability of misclassification was 3.8% with 150 scenarios, of the 156 analyzed and classified correctly. CONCLUSIONS: The previous parameters tested showed acceptable results for an evaluation tool. These results support the use of this algorithm as an aid in formulating clinical practice guidelines and to promote the appropriateness of TKR.

Algorithms↗

PubMedDate not supplied

[Prioritization of patients on the waiting list for hip and knee replacement: the patients' views].

OBJECTIVE: To identify patients' views on the criteria used to prioritize patients on the waiting list for total hip or knee prostheses. This study is part of a wider project whose objective is to design an instrument to prioritize patients on the waiting list for both procedures. MATERIAL AND METHODS: We performed a descriptive study with qualitative methodology that provides valuable information on how to improve various aspects of clinical practice and detect solutions that could be useful in decision making. There were 4 focus groups; 2 before the design of the instrument and 2 after. These focus group were composed of patients on the waiting list for knee or hip replacement. RESULTS: Thirty-one patients agreed to participate in the focus groups. All the patients were dissatisfied with the current waiting lists. The most salient factors discussed in meetings were pain, functional capability, and the repercussions of these on the patient's social role. CONCLUSIONS: Although the instrument is designed to be used by health professionals, patients' participation in its design and evaluation allows them to feel more involved in the healthcare process and provides information that more accurately reflects their experiences. The use of this information by health professionals will improve resource optimization and the response to patient needs.

Arthroplasty, Replacement, Hip↗

PubMedDate not supplied

[Retroperitoneal endoscopic nephrectomy].

OBJECTIVES: Nephrectomy is probably the most widely accepted procedure for the application of laparoscopic techniques in urology. The great advantages of laparoscopy over conventional approaches have justified its indication for different renal extirpative procedures: atrophy, renal carcinoma, transitional cell carcinoma, polycystic kidney disease, living kidney donation for transplantation and partial nephrectomies. The objective of this article is to describe the techniques and advantages of laparoscopic nephrectomy through a retroperitoneoscopic approach, demonstrating that it is an effective option for the majority of cases in which extraction of the kidney is required. METHODS: Between January 1991 and January 2001 107 patients with different renal conditions were treated at the Instituto Docente de Urología (IDU) using transperitoneal (36 patients) or retroperitoneal (71 patients) laparoscopic access. Indications for laparoscopic approach included atrophy, living donation, renal carcinoma, urothelial tumour, polycystic kidney disease and partial nephrectomy. RESULTS: Nephrectomy trough a transperitoneal approach was completed in 33 (91.6%) of 36 patients, being necessary to convert to conventional surgery in the remaining 3 cases (8.3%). Retroperitoneoscopic approach was successful in all cases (100%). CONCLUSIONS: The retroperitoneoscopic approach is a simple procedure that allows its implementation in the majority of patients in which there is an indication for nephrectomy. Retroperitoneoscopy provides a rapid recovery, minimal analgesic needs, and a short hospital stay. Finally, retroperitoneoscopic approach represents a logical evolution for conventional flank incisions, providing familiarity with surgical field landmarks and management to those urologists that incorporate this new technical modality.

Humans↗