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Biomedical subjects

Antonio A Barros Filho

Publications and source records attributed to Antonio A Barros Filho.

2 recordsLinked to original sources

[Monitoring growth].

OBJECTIVE: To present concepts related to growth assessment, with emphasis on aspects concerning the evaluation of individuals. SOURCES: The present paper is based on reports published by the WHO regarding the use anthropometry for the assessment of nutritional status; on original articles; and on book chapters about the same topic, as well as on the criticisms of auxologists of this type of assessment when employed at the individual level. SUMMARY OF THE FINDINGS: Concepts concerning reference, skeletal maturity, mid-parental target height, z score, short stature, growth rate, body mass index, and their assumptions and limitations are presented. CONCLUSIONS: The assessment of the nutritional status of a population is based on cut-off points, taking into consideration that whoever is below or above that point presents a nutritional problem. Clinical evaluation is based on the idea of variability, which can be both biological and social, and on the idea that it is the clinician's task to establish whether a child within or outside given parameters presents normal growth and nutritional status. When monitoring the growth of a child or adolescent, the most important parameter to be considered is growth rate.

Child Development↗

[Leptin as a marker of sexual dimorphism in newborn infants].

OBJECTIVE: To determine cord blood leptin levels in newborns appropriate for gestational age, according to gender, birth weight, birth height and ponderal index. METHODS: A cross-sectional study was carried out with 132 term newborns appropriate for gestational age (68 females, 64 males), gestational age between 35-42 weeks. Data were collected through interviews with the mothers at the maternity, anthropometrycal study of the newborns, and cord blood estradiol, testosterone and leptin assays obtained immediately after birth. RESULTS: The levels of leptin were significantly higher in females than in males (8.34+/-0.65 ng/ml versus 6.06+/-0.71 ng/ml; p = 0.000). The concentrations of estradiol and testosterone did not differ between males and females. Leptin levels were positively correlated with gestational age (r = 0.394, p < 0.01), birth weight (r = 0.466, p < 0.01), birth length (r = 0.335, p < 0.01) and ponderal index (r = 0.326, p < 0.01). CONCLUSIONS: Leptin concentration in the umbilical cord is positively correlated with gestational age, birth weight, birth height, and ponderal index, suggesting its participation in the neonatal growth process. In addition, a gender difference with higher levels of leptin in females neonates was observed, suggesting that the sexual dimorphism in relation to body composition already exists in newborns.

Biomarkers↗