Biomedical subjects

Anil Menon

Publications and source records attributed to Anil Menon.

3 recordsLinked to original sources

PubMed2003

Case studies in blend sampling using a front-loading thief.

In-process testing is employed in pharmaceutical systems for monitoring and detecting process failures. Blend sampling is a useful in-process test. The present article outlines case studies in which sampling thieves with front-loading and side-vented mechanisms were compared. Blend uniformity analysis (BUA) using a front-loading sampling thief helped confirm or discover blend homogeneity issues and guide the product development process to rational decision points by providing quick responses to actual or impending failure with a low probability of falsely declaring a failure that is not present.

Pharmaceutical Preparations↗

PubMed2002

Sequential experimentation in product development. I.

Investigations proceed as an iterative and recursive learning process, involving a sequence of experiments. Evaluating the results from a prior set of experiments allows the investigator to design and predict the next experimental cycle better. The investigator looks at what has gone before with a view to improve and extend the inquiry. This communication reiterates the value of sequential experimentation in product development. A fluid-bed granulation study is used to illustrate the sequential approach. Acceptable solutions were achieved using technical knowledge, a sequence of factorial designs, and graphical data analysis.

Pilot Projects↗

PubMed1996

Characterization of a Class of Sigmoid Functions with Applications to Neural Networks.

We study two classes of sigmoids: the simple sigmoids, defined to be odd, asymptotically bounded, completely monotone functions in one variable, and the hyperbolic sigmoids, a proper subset of simple sigmoids and a natural generalization of the hyperbolic tangent. We obtain a complete characterization for the inverses of hyperbolic sigmoids using Euler's incomplete beta functions, and describe composition rules that illustrate how such functions may be synthesized from others. These results are applied to two problems. First we show that with respect to simple sigmoids the continuous Cohen-Grossberg-Hopfield model can be reduced to the (associated) Legendre differential equations. Second, we show that the effect of using simple sigmoids as node transfer functions in a one-hidden layer feedforward network with one summing output may be interpreted as representing the output function as a Fourier series sine transform evaluated at the hidden layer node inputs, thus extending and complementing earlier results in this area. Copyright 1996 Elsevier Science Ltd

Journal Article↗