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Biomedical subjects

Angel Fernandez

Publications and source records attributed to Angel Fernandez.

3 recordsLinked to original sources

Retrieval-induced forgetting in perceptually driven memory tests.

Recent data (T. J. Perfect, C. J. A. Moulin, M. A. Conway, & E. Perry, 2002) have suggested that retrieval-induced forgetting (RIF) depends on conceptual memory because the effect is not found in perceptually driven tasks. In 3 experiments, the authors aimed to show that the presence of RIF depends on whether the procedure induces appropriate transfer between representations and competition rather than on the nature of the final test. The authors adapted the standard paradigm to introduce lexical categories (words that shared the first 2 letters) at study and practice. Direct and indirect fragment completion tests were used at retrieval. The results showed significant RIF effects in perceptually driven tasks. Furthermore, they indicated that the presence of RIF effects depended on using adequate cuing to induce competition during the retrieval practice and on the final memory test tapping the inhibited representation.

Adolescent↗

Free-association norms for the Spanish names of the Snodgrass and Vanderwart pictures.

The most frequent names in Spanish corresponding to a set of 247 pictures in the Snodgrass and Vanderwart (1980) norms were used as stimuli in a discrete free-association task. A sample of 525 Spanish-speaking participants provided the first word that came to mind for each of the verbal stimuli. Responses were organized according to frequency of production in order to prepare word-association norms for the set of stimuli.

Free Association↗

Factors associated with failure of metronidazole in Clostridium difficile-associated disease.

GOAL: To identify patients likely to fail metronidazole as initial treatment of C. difficile infection. BACKGROUND: For moderate to severe Clostridium difficile-associated diarrhea, metronidazole is the drug of choice for treatment. Oral vancomycin is given to patients who fail metronidazole or have intolerable side effects. STUDY: Retrospective review identified all patients treated for C. difficile-associated diarrhea during hospitalization from January 2000 to September 2001. C difficile was documented by a positive toxin assay or pseudomembranes on colonoscopy. Metronidazole failure was defined as persistent symptoms of C. difficile-associated diarrhea after 5 days of uninterrupted therapy. Response was defined as improvement in symptoms at day 5 of therapy including reduction of diarrhea to <or=2 bowel movements per day. RESULTS: 119 C. difficile-associated diarrhea patients were identified, and 99 met inclusion criteria. There were 61 (62%) metronidazole responders and 38 (38%) treatment failures. Albumin <2.5g/l and intensive care unit stay at/prior to diagnosis were the only variables associated with treatment failure. The odds ratios for treatment failure were 11.7 (95% confidence interval: 4.0-31.6) and 4.1 (95% confidence interval: 1.3-12.2), respectively. When considering these 2 variables together (low albumin, intensive care unit care), the area under the receiver operating characteristic curve was 0.80 for predicting treatment failure. CONCLUSIONS: Albumin level <2.5g/l and intensive care unit stay were predictors of failure of metronidazole therapy for C. difficile-associated diarrhea. These patients may benefit from oral vancomycin therapy at outset.

Adult↗