Biomedical subjects

Andrew R Thomson

Publications and source records attributed to Andrew R Thomson.

2 recordsLinked to original sources

PubMed2006

Switchable dual binding mode molecular shuttle.

[Structure: see text] Protonation controls the location of a dual binding mode macrocycle in a [2]rotaxane. In the neutral form, amide-amide hydrogen bonds hold the macrocycle over a dipeptide residue; when the thread is protonated, polyether-ammonium cation interactions dominate and the macrocycle changes position.

Journal Article↗

PubMed2006

Rotaxanes of cyclic peptides.

The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.

Nuclear Magnetic Resonance, Biomolecular↗