Two-stepping with E1.
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Bacterial Proteins↗
Biomedical subjects
Andrew P VanDemark
Publications and source records attributed to Andrew P VanDemark.
Structural basis of ubiquitylation.
The attachment of the small protein ubiquitin to other proteins, a process known as ubiquitylation, is a widespread form of post-translational modification that regulates numerous cellular functions in eukaryotes. Ubiquitylation is performed by complexes of E2 and E3 enzymes that are assembled and select substrates via a series of protein-protein interactions. Recent structure determinations of the ubiquitylation machinery have revealed some of the various protein-protein interfaces involved.
Ligases↗
SUMO wrestling with specificity.
A new structure reveals how substrates are recognized for conjugation to the ubiquitin-like protein SUMO, a posttranslational modification that functions in activation of transcription factors, nuclear import, and cell division.
Binding Sites↗