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Biomedical subjects

Andreas Perren

Publications and source records attributed to Andreas Perren.

6 recordsLinked to original sources
PubMed2005

Remember 'a posteriori diagnosis' of carbon monoxide poisoning.

OBJECTIVES: To raise awareness of the possibility of carbon monoxide poisoning as a diagnosis in the emergency department and to present the little known fact that it is possible to diagnose carbon monoxide poisoning retrospectively. METHOD: Presentation of a case report, review of the literature. RESULTS: Persistence of elevated carboxyhaemoglobin levels in a stored vacutainer blood sample. CONCLUSION: Carbon monoxide poisoning is common but often goes unrecognized. This method may help to decrease the number of overlooked cases and thereby possibly prevent further exposure and acute or chronic sequelae.

Adult↗
PubMed2002

Protocol-directed weaning from mechanical ventilation: clinical outcome in patients randomized for a 30-min or 120-min trial with pressure support ventilation.

OBJECTIVE: To investigate the possibility of successful extubation performing a spontaneous breathing trial (SBT) in pressure support ventilation (PSV) with target durations of 30 and 120 min. DESIGN AND SETTING: Prospective and randomized study in two medical-surgical adult intensive care units. PATIENTS AND PARTICIPANTS: 98 adult patients supported by mechanical ventilation for at least 48 h and considered ready for a weaning trial. INTERVENTIONS: An SBT conducted in PSV with 7 cmH(2)O and patients randomly assigned to two groups with target durations of 30- and 120-min. MEASUREMENTS AND RESULTS: In the 30-min group 43 patients (93%) tolerated the SBT and were extubated while 4 (9%) needed reintubation within 48 h; in the 120-min group 46 patients (88%) successfully completed the trial and were extubated while 2 (4%) were reintubated. ICU mortality in the groups with short and long periods was 6% and 4%, and in-hospital mortality 20% and 17%, respectively. Those successful in the 30- and 120-min groups had similar length of ICU stay (6 and 7 days, respectively) and in-hospital length of stay (20 and 25 days, respectively). Compared to the successfully extubated, the reintubated patients had significantly higher length of ICU stay and mortality (17 vs. 6 days and 33 vs. 3.6%, respectively). CONCLUSIONS: An SBT with PSV of 7 cmH(2)O lasting 30 min is equally effective in recognizing the successfully extubated patients as a 120-min trial.

Aged↗