Search PubMed⌕ Search

Biomedical subjects

Andreas K Demetriades

Publications and source records attributed to Andreas K Demetriades.

10 recordsLinked to original sources

Traumatic intraspinal extradural ganglion cyst in a teenager: case report and review of the literature.

Spinal extradural cyst is a rare cause of spinal cord or nerve root compression. We present a case which is unique due to both the young age of the patient and its distinctly acute haemorrhagic presentation. In what is normally considered a degenerative disease in older patients this has implications for the possibility of a traumatic aetiology in children. The literature on the classification of extradural cysts is reviewed.

Adolescent↗

Penetrating civilian craniocerebral gunshot wounds: a protocol of delayed surgery.

OBJECTIVE: Several factors have led to our unique approach of delayed definitive débridement. We wanted to evaluate the effectiveness of our management and compare it with the existing data in the literature. METHODS: We retrospectively reviewed the records of 194 patients presenting between January 1996 and October 2003 with penetrating craniocerebral gunshot wounds. After exclusion criteria, 125 patients qualified. RESULTS: Of the patients, 88.8% were male. The mean age was 24.9 +/- 10.9 years. In 70.4% of patients, the presenting Glasgow Coma Scale (GCS) score was 3 to 8. Only 38 (30.4%) of the 125 patients survived, with poor outcome in 2 and good outcome in 36. Bilaterally fixed and dilated pupils and bihemispheric tract on computed tomographic scan were significantly related to poor outcome. There were 49 surgical procedures performed on 27 of the patients, with a mortality rate of 7.4%. Of the 38 survivors, 13 underwent no surgery. Average time to surgery was 11.04 days. Total rate of infection was 8%, and it did not influence outcome. No patient presenting with a GCS score of 3 or 4 survived. Seventeen patients attended follow-up, for a total of 3609 days (average, 212 d) and very few late complications. CONCLUSION: Our supportive care of patients is not optimal. We should have saved more of our patients who presented with GCS scores of 14 and 15 who subsequently died. We have been able to report unconventionally late surgical management of two-thirds of survivors, with no surgery in one-third of survivors. Despite a high rate of infectious complications, infection did not lead to death or disability. Our protocol rarely leads to patients surviving in a permanently vegetative state. In the future, we would perform early surgery for patients who present awake and continue our current management for poor-grade patients. In this way, we will improve the number of good outcomes without increasing the population of severely damaged and dependent survivors.

Adolescent↗

Victor Horsley's contribution to the Foster Kennedy syndrome.

Although Foster Kennedy is the name given to the syndrome localizing an intracranial tumour with respect to papilloedema, it is important to recognize how Victor Horsley was one of the strongest proponents in the usefulness of that sign. Not only did he describe the constellation of findings before Kennedy did, he was also probably one of the people who had influenced Kennedy the most during the latter's time at the National Hospital for Nervous Diseases at Queen Square. It is therefore appropriate that Victor Horsley's characterization in 1910 of the findings that were later recorded as the Foster Kennedy syndrome, and that his altruistic encouragement of Kennedy's publication of the findings, receive recognition and appreciation in the medical and historical community.

Brain Neoplasms↗

Laennec's legacy.

Explore the source record for details and available documents.

Auscultation↗

Philoctetes.

Explore the source record for details and available documents.

Drama↗

Functional neuroimaging in Alzheimer's type dementia.

This article aims to review the role of the functional neuroimaging modality of positron emission tomography (PET) in the early diagnosis of Alzheimer's disease (AD). Clinical diagnosis in the early disease stages is difficult and treatments are emerging which rather than reversing structural damage are likely to slow or halt the disease process. While currently no routine diagnostic test confirms AD presence, imaging techniques are an important expanding field in biological neuropsychiatry. The challenge for neuroimaging methods is to achieve high specificity and sensitivity in early disease stages. Glucose metabolic PET imaging with fluorodeoxyglucose (FDG) has the potential to detect very early neocortical dysfunction before even abnormal neuropsychological testing is obtainable. The implications are for the identification of minimally symptomatic patients that could benefit most from treatment strategies, as well as the monitoring of treatment response and possible therapeutic deceleration of the disease. FDG PET correlates with AD neuropathology and is able to indicate disease progression or severity, meeting both functional neuroimaging prerequisites in diagnosing AD. A combination of functional neuroimaging with different techniques should be able to provide highest diagnostic specificity in diagnosing dementia. This may even lead to a new classification of dementias according to differences in the causative aetiology.

Aged↗