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Biomedical subjects

Altay Gezer

Publications and source records attributed to Altay Gezer.

5 recordsLinked to original sources

Hyperprolactinaemia does not always mean 'hyperprolactinaemia'!

The presence of macroprolactinaemia was investigated in the symptom-free hyperprolactinaemia cases to reveal its incidence. The serum prolactin (PRL) fractions in 21 female patients with hyperprolactinaemia without any clinical symptoms were analyzed with PEG (polyethylene glycol precipitation) procedure. In 14 of these 21 cases, hyperprolactinaemia was detected with a high fraction of macroprolactin. In cases with asymptomatic hyperprolactinaemia, it is more appropriate to employ the PEG precipitation test to detect the disorder. High levels of serum prolactin, do not essentially indicate the presence of a prolactinoma but may only indicate macroprolactinaemia.

Adult↗

Seventeen-year review of hysterectomy procedures in a university clinic in Istanbul (1985-2001).

OBJECTIVE: Our objective was to review the hysterectomies performed in our clinic for the last 17 years to reveal the facts in relation to the operation. MATERIALS AND METHODS: The records of the patients who had undergone hysterectomy in Istanbul University Cerrahpasa School of Medicine Department of Obstetrics and Gynecology between January 1985 and August 2001 were reviewed retrospectively. Students' t-test and one-way ANOVA test were utilized to compare the data of different hysterectomy groups. RESULTS: Between 1985 and 2001, there were 3,956 women who had undergone hysterectomy operation in the Department of Obstetrics and Gynecology of Cerrahpasa School of Medicine, Istanbul University. There were 3,274 (82.7%) total abdominal hysterectomies (TAH), 424 (10.7%) total vaginal hysterectomies (TVH), 28 (0.7%) subtotal hysterectomies and 230 (5.8%) radical hysterectomies. There were no significant differences in the distribution of hysterectomy type with respect to interval of years. The common indications for hysterectomy were myoma uteri (38.49%), followed by gynecological cancers (21.6%) and uterine prolapse (11.9%). The rate of concurrent procedures were 87.3% for TAH (2,856/3,274) and 95.8% for TVH (406/424). The rate of 'unjustified' hysterectomies (pathological diagnosis that is inappropriate to the indication of the operation) determined as 8.9% in all of the cases. The pathological examination of the specimen was normal in 170 cases (5.1%) of TAH. This rate was 42.1% (183/435) in TVH group. In the TAH group there was no complication in 86.5% of the cases while it was 89.3% in the TVH group. The most common complication was febrile morbidity in the whole group. During the study period, 5 deaths that can be attributed to the hysterectomy operation were observed. The mortality rate was calculated as 0.1% for hysterectomy operation in the study period. CONCLUSION: Although it is widely performed, hysterectomy is a relatively safe surgical procedure. The morbidity and mortality of the operation may be further decreased by the efforts to minimize the rate of the unnecessary hysterectomies and selecting the most appropriate mode for the surgery.

Academic Medical Centers↗

Laparoscopic management of cornual pregnancy without sutures.

INTRODUCTION: Cornual pregnancy is a rare form of ectopic pregnancy. The incidence is reported as 3% of all ectopic pregnancies accounting 20% of deaths due to ectopic pregnancy. When an unruptured cornual pregnancy is diagnosed, there are a variety of management options. Many successful endoscopic management options for cornual pregnancy have been reported. CASE REPORT: In this case, cornual resection was performed. DISCUSSION: The other possible treatment options were reviewed.

Adult↗

Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels.

OBJECTIVE: To investigate the relationship of neonatal bilirubin levels to oxytocin infusion and the diluent used for oxytocin infusion. MATERIALS AND METHODS: The study was carried out as a prospective, randomized study in Istanbul University Cerrahpasa School of Medicine, Department of Obstetrics and Gynecology between January to December in 1995. A total of 80 patients managed with oxytocin during labor, enrolled to the study. These patients randomly divided into isotonic % 0.9 saline (Group 1) and 5% glucose solutions (Group 2) by a consecutive order using a balanced block randomization scheme. Forty multiparous patients delivering without oxytocin infusion formed the control group (Group 3). The details of maternal age, gestational age, labor duration, mode of delivery, birth weight of the babies, total volume of fluid administered until delivery and total oxytocin dose were noted in each case. Sodium and initial bilirubin levels were measured in the cord blood. Later on, capillary blood bilirubin and hematocrit concentrations were measured on day 1 and 2 in the newborn nursery. The groups were compared according to these parameters. RESULTS: The data of 29 patients in Group 1, 36 patients in Group 2 and 40 patients in Group 3 were suitable for analysis. The difference between study and control groups regarding the rate of hyponatremia, neonatal hyperbilirubinemia and neonatal jaundice was not statistically significant. Cord plasma sodium levels, cord plasma bilirubin levels and day 1 and 2 hematocrit and plasma bilirubin levels were not statistically different between the groups. irrespective of the diluent used, the cord plasma bilirubin levels and day 2 plasma bilirubin levels were significantly higher in the accelerated group. CONCLUSION: No significant effect of oxytocin infusion was revealed on neonatal hyperbilirubinemia unless oxytocin was for the augmentation of labor.

Bilirubin↗