A new avenue for mass spectrometry.
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Bacterial Proteins↗
Biomedical subjects
Allison Doerr
Publications and source records attributed to Allison Doerr.
A synthetic classic reinvented.
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Alkadienes↗
Michaelis-Menten for single enzyme molecules.
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Catalysis↗
Hands-off protein crystallography.
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Crystallization↗
Chemical nano-corking.
Silica nano test tubes used as delivery vehicles can be 'corked' with nanoparticles using chemical self-assembly.
Drug Delivery Systems↗
SAILing toward larger protein structures.
With a new method for optimizing the amino acid isotopic labeling pattern, stereo-array isotope labeling (SAIL), structures of large proteins (up to 50 kDa) can now be solved with ease with nuclear magnetic resonance (NMR) spectroscopy.
Amino Acids↗
Proteins: caught in the trap.
Two independent groups have recently devised innovative methods using light to trap and manipulate particles as small as proteins.
Elasticity↗
Showing 'support' for chemical protein synthesis.
Researchers demonstrate that in addition to protein ligation, folding and functional assays can be performed on proteins while they are still attached to a water-compatible solid support.
Binding Sites↗
Microscopy matures, and so does the Golgi.
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Golgi Apparatus↗
An affinity for new proteins.
Metabolic incorporation of an unnatural amino acid allows researchers to rapidly affinity purify newly synthesized proteins from mammalian cell lysates for direct identification by mass spectrometry.
Affinity Labels↗
Pushing size to the limit: extreme DNA.
Double-wide pyrimidine bases can assemble into helical, sequence-specific DNA complexes.
Animals↗
Bacteria make the rotor go round.
The gliding bacteria Mycoplasma mobile yoked to an inorganic rotor will turn it along a circular track, generating a tiny biological hybrid motor.
Bacterial Adhesion↗
Sweetening up yeast glycoprotein synthesis.
An engineered yeast strain is capable of carrying out the full range of human protein glycosylation reactions.
Animals↗
Widening the protein crystallization bottleneck.
Two recent reports describe simple methods that may help expand the range of proteins amenable to crystallization.
Binding Sites↗
Protein microarray velcro.
A designed polypeptide scaffold contains a surface immobilization domain and a target capture domain for flexible protein arraying.
Adsorption↗
Tackling biology's big question.
Working from opposite ends of the protein folding problem, two research teams have developed powerful mathematical strategies that offer the potential to greatly clarify the relationship between primary sequence and native structure.
Models, Chemical↗
A synthetic solution to gene delivery.
A self-assembling polymer-DNA nanoparticle serves as a vehicle for highly efficient gene delivery to cells.
Biopolymers↗
Teaching cell biologists how to count.
To truly understand the biochemistry of cellular systems, the concentrations of the endogenous protein players must be known, and these can be obtained by careful quantification of fluorescent fusion proteins.
Biomarkers↗