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Biomedical subjects

Alison R Preston

Publications and source records attributed to Alison R Preston.

6 recordsLinked to original sources
PubMed2004

Comparison of spiral-in/out and spiral-out BOLD fMRI at 1.5 and 3 T.

Spiral-in/out functional magnetic resonance imaging (fMRI) methods acquire one image before the echo time (TE) and a second image after TE during each scan. Weighted combination of the two images provides a time series with reduced susceptibility dropout in frontal and medial temporal regions as well as increased signal-to-noise ratio (SNR) in regions of uniform cortex. In this study, task activation with the spiral-in/out method was compared to that with conventional spiral-out acquisitions at two field strengths (1.5 and 3.0 T) using episodic memory encoding, verbal working memory, and affective processing tasks in eight human volunteers. With the conventional spiral-out sequence, greater signal dropout is observed in lateral and medial prefrontal, amygdalar, and medial temporal regions at 3 T relative to 1.5 T, whereas such dropout at 3 T is reduced or mitigated with the spiral-in/out method. Similarly, activation volumes for frontal, amygdalar, and medial temporal regions are reduced for spiral-out acquisitions relative to spiral-in/out, and this difference is more apparent at 3 T than at 1.5 T. In addition, significant regionally specific increases in Z scores are obtained with the spiral-in/out sequence relative to spiral-out acquisitions at both field strengths. It is concluded the spiral-in/out sequence may provide significant advantages over conventional spiral methods, especially at 3 T.

Adult↗
PubMed2003

Visualizing genetic influences on human brain functions.

, in this issue of Cell, integrate genetics and functional brain imaging by showing that variation in the human brain-derived neurotrophic factor (BDNF) gene is associated with variation in episodic memory ability and in hippocampal neurochemistry and function.

Brain-Derived Neurotrophic Factor↗
PubMed2003

Working smarter, not harder.

The ability to chunk, or to strategically organize, information is one of the most powerful ways people have to encode experience into memory. A functional brain imaging study by Bor and colleagues, in this issue of Neuron, provides evidence that prefrontal cortex contributes to this essential mnemonic process.

Diagnostic Imaging↗