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Biomedical subjects

Alemka Jaklin Kekez

Publications and source records attributed to Alemka Jaklin Kekez.

2 recordsLinked to original sources

[Viral hepatitis: Croatian consensus statement].

There has been a dramatic improvement in diagnostic procedures and therapy of viral hepatitis in the last 20 years. Improvements in therapy caused an increase in actual cost, however, with significant long-term savings through a decreased cost of treatment of advanced liver disease including liver transplantation. The Croatian National Board for Viral Hepatitis has decided to initiate the organization of consensus conference on viral hepatitis enabling the leading experts in the country to give the best possible recommendations for the diagnosis, prophylaxis and therapy in our circumstances. The Consensus Conference took place in Zagreb in June 2004, with update in March 2005, organized by the Croatian National Board for Viral Hepatitis, Reference Centers of the Ministry of Health for Chronic Liver Diseases, Infectious Diseases and AIDS, Croatian Society of Gastroenterology--Hepatology Section, Croatian Society for Nephrology, Dialysis and Transplantation, and Croatian Institute for Health Insurance. Invited experts provided written reports on the respective subjects that appear in this issue and their recommendations resulting in this consensus statement.

Consensus Statements as Topic↗

[Treatment of viral hepatitis in children].

The goal of treating children with chronic hepatitis B is the prevention of complications rather than the urgency of stopping the disease. Candidates for treatment are HBV DNA and HBeAg positive children, older than 2 years, with elevated transaminases for at least 6 months and histologic evidence for chronic hepatitis. Treatment can be carried out with interferon alfa or lamivudine, however, interferon is preferred for higher efficacy. The combined therapy has been currently studied. No consensus has yet been attained on the necessity to treat chronic hepatitis C in children. Candidates for treatment are HCV RNA positive children, older than 3 years, having persistently elevated transaminases, with histologic evidence for chronic hepatitis and significant fibrosis. Until recently, treatment was carried out with interferon alfa, but now, due to better results, a combined therapy with interferon alfa and ribavirin is recommended. New controlled trials are expected as a basis for general recommendations.

Child↗