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Biomedical subjects

Alan T N Tita

Publications and source records attributed to Alan T N Tita.

9 recordsLinked to original sources
PubMed2006

Evidence-based reproductive health care in Cameroon: population-based study of awareness, use and barriers.

OBJECTIVE: To estimate the prevalence of awareness and use of evidence-based reproductive health interventions and to describe the barriers associated with the use of evidence-based interventions among health providers in north-west Cameroon. METHODS: In February 2004, a population-based descriptive study of the awareness and use of 13 evidence-based interventions targeted health workers providing reproductive health care. Their awareness and use of a composite of four vital interventions was also evaluated. These were peripartum use of antiretrovirals to prevent transmission of HIV, antenatal corticosteroid administration, magnesium sulfate prophylaxis and active management of placental delivery with uterotonics. In-depth interviews with key informants were conducted as part of a qualitative substudy to discover the barriers to the use of evidence-based interventions. FINDINGS: Overall, 91.4% (328/359) of reproductive health workers were surveyed. Their awareness of evidence-based interventions varied from 29% for the use of antenatal corticosteroids to 97% for the use of iron and folic acid supplementation during pregnancy. Their use of these interventions ranged from 10.2% for antenatal corticosteroids to 94.8% for iron and folic acid supplementation. Only 50/322 (15.5%; 95% confidence interval (CI)=11.8-20.0) of health workers were aware of all four vital interventions, and only 12/312 (3.8%; 95% CI=2.0- 6.6) reported using all of them regularly. A total of 26 key informants participated in the qualitative substudy. A deficiency in the education and training of health workers, especially a lack of continuing education, was commonly identified as the most important barrier to their awareness of evidence-based practices. A lack of awareness and a lack of supplies and materials were the main barriers to practice. CONCLUSION: The awareness and practice of important evidence-based reproductive health interventions were less than optimal. To improve maternal and perinatal outcomes both remedial programmes to enhance awareness, including continuing education for health workers, and the provision of necessary supplies are needed.

Adrenal Cortex Hormones↗
PubMed2006

Impact of anomalous triplets on morbidity outcomes of normal in utero siblings.

OBJECTIVE: To evaluate the impact of number of anomalous fetuses on the prevalence of very preterm births (< 32 weeks), very low birth weight (< 1,500 g), and small for gestational age (SGA) infants among their normal cotriplets. METHODS: Cross-sectional study of United States triplet births from 1995 to 2000 using Matched Multiple Birth Files, comparing outcomes for triplet sets with no anomalous, 1 anomalous, and 2 anomalous fetuses. Chi-square test for trend and multiple logistic regression analyses, applying generalized estimating equations to account for correlation among cotriplets, were implemented. RESULTS: Of 34,881 matched triplets, 34,104 (97.8%) were nonanomalous (2.2% prevalence of fetal anomaly). Prevalence of very preterm birth (P < .001) and very low birth weight (P < .001), but not SGA (P = .52), among nonanomalous births increased significantly with number of anomalous cotriplets. The prevalence of very preterm birth was 44.1%, 54.8%, and 68.8%, respectively, as number of anomalous triplets per set increased from none to two. The prevalence of very low birth weight was 32.3%, 39.6%, and 62.0%, respectively. These trends remained unchanged after adjustment for correlation and potential confounding. CONCLUSION: Prevalence of triplet births with gestation less than 32 weeks and birth weight less than 1,500 g, but not SGA, among nonanomalous triplets increase linearly with number of anomalous members within triplet sets. LEVEL OF EVIDENCE: III.

Adult↗
PubMed2006

Antenatal herpes serologic screening: an appraisal of the evidence.

OBJECTIVE: Calls for universal antenatal type-specific herpes simplex virus (HSV) screening to prevent neonatal herpes have recently increased and would affect the four million pregnant women and their partners annually in the United States. We undertook this review to assess the appropriateness of such screening, making relevant comparisons to established antenatal human immunodeficiency virus (HIV) and hepatitis B virus (HBV) screening programs. DATA SOURCES: We conducted a full PubMed and bibliographic search for relevant literature in English available from 1966 through February 2006, using the terms "genital herpes," "neonatal herpes," "decision analysis" or "cost-effectiveness analysis," and "herpes and pregnancy" or "antenatal herpes screening." Comparison literature was obtained by replacing "herpes" with "HBV" or "HIV". METHODS OF STUDY SELECTION: We appraised antenatal type-specific HSV screening using well-established criteria for a good screening program, which we articulated as questions. Of 455 articles we selected those that addressed at least one of the questions and were pertinent to the U.S. population. TABULATION, INTEGRATION, AND RESULTS: We found that neonatal HSV is rare and its incidence is imprecisely defined. There is a lack of evidence supporting the effectiveness of interventions to prevent maternal acquisition of new infection in late pregnancy, which accounts for 60-80% of neonatal herpes. The consequences of universal screening are incompletely understood but include the potential for unnecessary cesarean deliveries and medical treatment, maternal psychosocial stress, and discord among partners. The available evidence indicates universal screening is not cost-effective. In contrast, antenatal HIV and HBV screening programs better satisfy accepted criteria for screening. CONCLUSION: On the basis of this appraisal, universal antenatal type-specific HSV screening to prevent neonatal herpes does not adequately satisfy criteria of a good screening program, and we recommend against its adoption.

Cost-Benefit Analysis↗
PubMed2005

Seasonality and immediate antecedents of sexual intercourse in adolescents.

OBJECTIVE: To assess immediate antecedents of and seasonal variations in sexual intercourse among a focused population of medically indigent adolescent females in Houston, Texas. STUDY DESIGN: From June 2001 to March 2002 we solicited a convenience sample of adolescent females during their visit to a school-based clinic. The survey consisted of 34 multiple choice questions targeting immediate antecedents of sexual behavior. Demographic characteristics and survey responses were compared with t tests and ANOVA. The chi2 goodness of fit test and test of homogeneity were used to assess seasonality. RESULTS: One hundred thirty-three teenagers completed our survey. Both African American and Hispanic teens were significantly more likely to report that their sexual debut occurred in June (p < 0.01 and = 0.02, respectively). More than 50% of those surveyed reported having sex either in their homes or in the homes of their partners. Doing "nothing" was the most common antecedent activity for sexual intercourse. There were no statistically significant differences in location or antecedent activity for first or most recent sexual intercourse between teens with and without prior pregnancy. CONCLUSION: Both the timing and location of sexual intercourse among the teens in this study suggest that unsupervised time may be a factor contributing to sexual activity in teens.

Adolescent↗
PubMed2003

Association between prepregnancy maternal body mass index and the risk of having an infant with a congenital diaphragmatic hernia.

BACKGROUND: A previous study observed that women who are underweight prior to conception were significantly more likely to have infants affected by congenital diaphragmatic hernia (CDH). The objective of the current study was to examine the association between maternal body mass index and the risk of a CDH-affected offspring based on a larger number of cases of CDH. METHODS: A case control study was conducted using data collected by the Boston University Slone Epidemiology Center Birth Defects Study, which identifies infants with major malformations who are born in the metropolitan area surrounding Boston, Massachusetts; Philadelphia, Pennsylvania; and Toronto, Ontario, Canada. Control infants were selected from infants without malformations who were born in the same areas. The study included 85 cases of CDH and 655 controls delivered between 1993 and 1997. RESULTS: After adjustment for maternal education and maternal age, we observed that women who were thin or underweight for their height (body mass index < or = 19.0 kg/m2) had an increased risk of having an infant with isolated CDH (OR = 1.9; 95% CI = 0.92-4.1), but no increase in the risk of having a CDH infant with multiple defects (OR = 0.86; 95% CI = 0.29-2.6) compared with all other women. CONCLUSIONS: Although our finding for isolated CDH was not statistically significant (P = 0.08), it suggests that the offspring of thin or underweight women may have an increased risk of isolated CDH. This finding requires confirmation. If it is confirmed, further research on factors associated with being underweight should be explored such as diet, exercise, and use of drugs.

Body Mass Index↗