Biomedical subjects

Alan Richardson-Klavehn

Publications and source records attributed to Alan Richardson-Klavehn.

8 recordsLinked to original sources

PubMed2006

Neuroanatomical dissociation of encoding processes related to priming and explicit memory.

Priming is a facilitation of cognitive processing with stimulus repetition that can occur without explicit memory. Whereas the functional neuroanatomy of perceptual priming at retrieval is established, encoding processes that initiate priming and explicit memory have not yet been anatomically separated, and we investigated them using event-related functional magnetic resonance imaging. Activations predicting later explicit memory occurred in the bilateral medial temporal lobe (MTL) and left prefrontal cortex (PFC). Activity predicting later priming did not occur in these areas, but rather in the bilateral extrastriate cortex, left fusiform gyrus, and bilateral inferior PFC, areas linked with stimulus identification. Surprisingly, these regions showed response reductions. Our results demonstrate that priming and explicit memory have distinct functional neuroanatomies at encoding, with MTL activations being specific for explicit memory, and suggest that priming is initiated by sharpness of neural responding in stimulus identification areas, consistent with recent electrophysiological evidence regarding priming-related neural oscillations at encoding. We tentatively suggest that this sharpened responding at encoding may set the stage for increased neural processing efficiency at retrieval, with these different neural mechanisms both leading to observed priming-related hemodynamic decreases, and argue that neural measurements at encoding, and not just at retrieval, will be critical in resolving the debate about the neural mechanisms of learning that underlie priming.

Adolescent↗

PubMed2005

Early, partly anticipatory, neural oscillations during identification set the stage for priming.

Perceptual priming is a fundamental long-term memory capability by which exposure to a stimulus improves later perceptual processing of that stimulus. A widespread hypothesis is that priming is the later result of perceptual learning during stimulus identification. Testing this hypothesis involves isolating priming without explicit memory, and appropriately measuring brain activity during initial experimental exposure to assess whether brain activity related to identification differs as a function of later priming. Here, we show, using magnetoencephalography (MEG), that words primed in a later test are distinguished from unprimed words at initial exposure by (a) more specific responses in perceptual brain areas, indicated by an early (within 240 ms after word onset) decrease in amplitude but increase in phase alignment of beta and gamma oscillations, and (b) improved coordination of responses across perceptual and higher brain areas in the same time window, indicated by an increase in interareal phase synchrony of alpha oscillations. The increase in interareal phase synchrony partly started already in the pre-stimulus period, approximately 60-80 ms prior to word onset, showing that the improved coordination of responses across areas was partly anticipatory. The anatomy and early timing of these patterns reveal a neural link between identification and long-term memory. The pre-stimulus findings additionally show that priming is related to the stimulus-specific anticipatory state of visual identification areas at initial exposure.

Adult↗

PubMed2005

Redefining implicit and explicit memory: the functional neuroanatomy of priming, remembering, and control of retrieval.

We used event-related functional MRI to study awareness of prior episodes during memory retrieval and its relationship to the intention to retrieve memories. Participants completed cues with words from a prior list (intentional test) or with the first words that came to mind (incidental test). During both tests, explicit memory was separated from priming in the absence of explicit memory. Priming was associated with hemodynamic decreases in left fusiform gyrus and bilateral frontal and occipital brain regions; explicit memory was associated with bilateral parietal and temporal and left frontal increases. Retrieval intention did not change these patterns but was associated with activity in right prefrontal cortex. Our results provide firm evidence that implicit and explicit memory have distinct functional neuroanatomies, and that strategic control of retrieval engages brain structures distinct from those involved in both implicit and explicit memory. They have critical implications for theories of memory and consciousness, which often equate consciousness with control.

Adolescent↗

PubMed2005

Recapitulating emotional context: activity of amygdala, hippocampus and fusiform cortex during recollection and familiarity.

The amygdala is thought to enhance long-term memory for emotionally arousing events by modulating memory formation and storage in the hippocampus and in neocortical areas. Recent animal studies have raised the possibility that cooperativity between amygdala and hippocampus contributes to the retrieval of fear memories. The functional contributions of the amygdala to the retrieval of emotional memories in humans are less well known. Here, in a functional magnetic resonance imaging experiment, 20 healthy subjects studied neutral words in the context of a fearful or a neutral human face. In a subsequent test, they made 'remember' (conscious recollection of the study context), 'know' (familiarity in the absence of conscious recollection) and 'new' judgements on the studied and newly presented neutral words, in the absence of face stimuli. At test, bilateral amygdala, hippocampus and fusiform face area (FFA) were more strongly activated during recollection than during familiarity. Higher activity for fearful than for neutral study context was found in bilateral FFA during recollection but not during familiarity. This difference recapitulated higher activity for fearful than for neutral context in the FFA during study. These data suggest that the amygdalae and hippocampi contribute to the retrieval of emotion-laden context memories by coordinating the reactivation of stored representations in neocortical areas, such as the FFA. However, there also was a recapitulation of emotional study context in the right amygdala during familiarity only, which might therefore be related to affective implicit memory.

Adult↗

PubMed2004

Level of processing and age affect involuntary conceptual priming of weak but not strong associates.

Memory for weak and strong semantic associates was compared in intentional associate-cued-recall and incidental free-association tests. This design yielded four conditions (weak/intentional, strong/intentional, weak/incidental, and strong/ incidental) on which younger and older adults were compared. Level of processing (LOP) and age effects occurred for the weak/intentional, strong/intentional, and weak/incidental conditions, but not for the strong/incidental condition. Because participants could not distinguish weak from strong associates during the memory tests, these results suggest that free-association priming was involuntary and was not contaminated by voluntary retrieval strategies. Instead, they suggest that encoding deficits related to shallower LOP and older age reduce involuntary free-association priming mainly for associates without cohesive preexperimental representations.

Adolescent↗

PubMed2002

Perceptual priming versus explicit memory: dissociable neural correlates at encoding.

We addressed the hypothesis that perceptual priming and explicit memory have distinct neural correlates at encoding. Event-related potentials (ERPs) were recorded while participants studied visually presented words at deep versus shallow levels of processing (LOPs). The ERPs were sorted by whether or not participants later used studied words as completions to three-letter word stems in an intentional memory test, and by whether or not they indicated that these completions were remembered from the study list. Study trials from which words were later used and not remembered (primed trials) and study trials from which words were later used and remembered (remembered trials) were compared to study trials from which words were later not used (forgotten trials), in order to measure the ERP difference associated with later memory (DM effect). Primed trials involved an early (200-450 msec) centroparietal negative-going DM effect. Remembered trials involved a late (900-1200 msec) right frontal, positive-going DM effect regardless of LOP, as well as an earlier (600-800 msec) central, positive-going DM effect during shallow study processing only. All three DM effects differed topographically, and, in terms of their onset or duration, from the extended (600-1200 msec) fronto-central, positive-going shift for deep compared with shallow study processing. The results provide the first clear evidence that perceptual priming and explicit memory have distinct neural correlates at encoding, consistent with Tulving and Schacter's (1990) distinction between brain systems concerned with perceptual representation versus semantic and episodic memory. They also shed additional light on encoding processes associated with later explicit memory, by suggesting that brain processes influenced by LOP set the stage for other, at least partially separable, brain processes that are more directly related to encoding success.

Adult↗

PubMed2002

Recognition memory and decision processes: a meta-analysis of remember, know, and guess responses.

A meta-analysis of proportions of remember, know, and guess responses was carried out on observations from 86 experimental conditions in 23 different recognition memory experiments. Unlike remember and know responses, guess responses revealed no memory for the test items that elicited them. A signal detection analysis of these data showed that A' estimates of the strength of the memory trace depended on response criteria. A' estimates increased significantly when know responses were added to remember responses, and decreased significantly when guess responses were added to remember and know responses. It was guessing, rather than knowing, that was most strongly correlated with overall response criteria. Nor were remembering and knowing correlated significantly. These results do not support a quantitative trace strength model according to which these responses merely reflect different response criteria. They support theories that ascribe remembering and knowing to qualitatively distinct memory systems or processes.

Cognition↗

PubMedDate not supplied

Level of processing and the process-dissociation procedure: elusiveness of null effects on estimates of automatic retrieval.

We describe two experiments that used the process-dissociation procedure to investigate the effects of level of processing on estimates of controlled and automatic retrieval processes in word-stem completion tasks. Despite our best endeavours, we found the null effect of level of processing on estimates of automatic retrieval reported by Toth, Reingold, and Jacoby (1994) elusive. Estimates of automatic retrieval were not independent of level of processing but inversely related to it. In part, the reason was that, following deeper levels of processing, instructions to exclude recollected words led to floor effects. But the inverse relationship persisted even when floor effects were avoided. Only participants who were not given strict instructions in the exclusion task-and who also qualified as lax responders based on answers in a structured post-test interview-showed no effect of level of processing on estimates of automatic retrieval. This null effect apparently occurred because these participants failed to exclude words that they in fact recollected from the study list. This finding violates the critical assumption that in this task participants exclude recollected words. The results are therefore paradoxical. Successful replication of the null effect occurred only under conditions that preclude the very use of the procedure. This paradox has important implications for views on how consciousness should be conceived in relation to memory.

Adult↗