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Biomedical subjects

Alan C Jackson

Publications and source records attributed to Alan C Jackson.

5 recordsLinked to original sources
PubMed2003

Rabies virus infection: an update.

There are still many unanswered questions in the pathogenesis of rabies, but recent progress has been made. During most of the long incubation period of rabies, the virus likely remains close the site of viral entry. Centripetal spread to the central nervous system and spread within the central nervous system occur by fast axonal transport. Neuronal dysfunction, rather than neuronal death, is responsible for the clinical features and fatal outcome in natural rabies. Recent work has changed our perspective on the ecology of rabies virus under particular circumstances in certain species. Hopefully, advances in our understanding of rabies pathogenesis will lead to advances in the treatment of this dreaded disease.

Animals↗
PubMed2002

Management of rabies in humans.

Rabies is a fatal disease in humans, and, to date, the only survivors of the disease have received rabies vaccine before the onset of illness. The approach to management of the rabies normally should be palliative. In unusual circumstances, a decision may be made to use an aggressive approach to therapy for patients who present at an early stage of clinical disease. No single therapeutic agent is likely to be effective, but a combination of specific therapies could be considered, including rabies vaccine, rabies immunoglobulin, monoclonal antibodies, ribavirin, interferon-alpha, and ketamine. Corticosteroids should not be used. As research advances, new agents may become available in the future for the treatment of human rabies.

Adrenal Cortex Hormones↗
PubMed2002

Update on rabies.

Rabies remains an important public health problem worldwide due to endemic dog rabies in developing countries. Rabies was a re-emerging disease in the United States during the 1990s due to bat rabies virus variants. Australian bat lyssavirus also emerged in Australian bat populations and caused two human deaths. There have been important recent advances in our knowledge of the pathogenesis of rabies and in our ability to diagnose and prevent it.

Animals↗