Cutaneous and systemic plasmacytosis.
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Aged↗
Biomedical subjects
Aimee L Leonard
Publications and source records attributed to Aimee L Leonard.
Surgical Pearl: The use of a laboratory vortex for poly-L-lactic acid injection.
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Biocompatible Materials↗
Cutaneous malignant melanoma.
Skin cancer has become the most common neoplasm in the United States. With early diagnosis and appropriate management, most skin cancers have an overall 5-year survival rate of 95%. Cutaneous malignant melanoma (CMM), however, has a significantly higher morbidity and mortality, resulting in 65% of all skin cancer deaths. Although the long-term survival rate for patients with metastatic melanoma is only 5%, early detection of CMM carries an excellent prognosis, with surgical excision often being curative. Primary care physicians can play a critical role in reducing morbidity and mortality from CMM by recognizing patients at risk, encouraging the adoption of risk-reducing behaviors, and becoming adept at identifying suspicious lesions.
Humans↗
Treatment of giant keratoacanthoma with intralesional 5-fluorouracil.
Giant keratoacanthomas measure greater than 2 cm and have a predilection for the nose and eyelids. As a result, they often present a significant therapeutic challenge. A 36-year old woman was referred for evaluation of a 4.0 x 4.0 cm giant keratoacanthoma on the nose. The patient was treated with intralesional 5-fluorouracil, and the tumor underwent complete regression leaving a full thickness nasal cleft. The defect was then reconstructed with a paramedian forehead flap with good cosmesis.
Adult↗
A protocol for facial volume restoration with poly-L-lactic acid.
Poly-L-lactic acid is a biodegradable synthetic polymer used in an injectable form for subcutaneous volume restoration. Volumetric correction following subcutaneous and deep dermal injection of poly-L-lactic acid is thought to occur through a foreign body tissue response leading to increased production of fibroblasts and subsequent neocollagenesis. Despite the growing popularity and use of this material, there has been a scarcity of published information describing proper injection technique, and many practitioners remain unfamiliar with its use. Appropriate injection technique is critical since incorrect placement of the material can lead to long-lasting unintended results. We present a protocol for successful injection of poly-L-lactic acid into the submalar and buccal regions.
Biocompatible Materials↗
A case of sarcoidosis mimicking rhinophyma.
A 54-year-old man presented with symmetric, bulbous, nodular enlargement of his nasal tip and ala. At first inspection, the changes appeared to be consistent with rhinophyma, but biopsy revealed noncaseating granulomata consistent with sarcoidosis. His laboratory, radiographic, and functional studies were consistent with systemic involvement of his disease.
Diagnosis, Differential↗
Palmoplantar keratoderma of Sybert.
A 13-year-old boy and a 7-year-old boy, who are brothers, presented with a life-long history of erythema, hyperkeratosis, and desquamation of the hands and feet. Symptoms improved with the use of topical glucocorticoids and keratolytics. PPK of Sybert is characterized by palmoplantar hyperkeratosis with transgrediens, autosomal dominant inheritance, and the absence of associated systemic features.
Administration, Topical↗
Sarcoidosis.
A 54-year-old man presented with symmetric, bulbous, nodular enlargement of the nasal tip and alae nasi. At first inspection, the changes appeared to be consistent with rhinophyma, but a biopsy specimen showed noncaseating granulomata that were consistent with sarcoidosis. His laboratory, radiographic, and pulmonary function studies were consistent with systemic involvement.
Facial Dermatoses↗
Epidermal nevus.
A 20-year-old woman presented with an asymptomatic, life-long, verrucous, hyperpigmented plaque on the face and neck that corresponded to the lines of Blaschko. Histopathologic examination shows an epidermal nevus. This nevus presents a challenge in management because of the location and extent of the lesion.
Adult↗