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Adrian Glasser

Publications and source records attributed to Adrian Glasser.

27 records · Page 2Linked to original sources

Accommodation measurements in a prepresbyopic and presbyopic population.

PURPOSE: To study the efficacy of several subjective and objective methods of accommodation measurement in normal prepresbyopic and presbyopic populations to identify appropriate methods for measuring the outcome of accommodative restorative procedures. SETTING: University of Houston, College of Optometry, Houston, Texas, USA. METHODS: Thirty-one normal subjects with a mean age of 43.7 years (range 31 to 53 years) participated. Accommodation was measured monocularly using 3 subjective approaches--the push-up test, minus lenses to blur, and a focometer--and 2 approaches measured with a Hartinger coincidence refractometer, in which accommodation was stimulated with minus lenses to blur and topical pilocarpine 6%. RESULTS: The push-up method overestimated accommodative amplitude relative to objective measures in 28 subjects. Two subjective methods, minus lenses to blur and the focometer, produced comparable results, but with lower amplitudes in younger subjects and higher amplitudes in older subjects compared with objective methods. Comparable results were obtained when accommodation was stimulated in 1 of 2 ways and measured with the Hartinger. Pilocarpine elicited stronger accommodative responses than distance blur for subjects with low accommodative amplitudes. Pilocarpine 6% produced stronger responses in subjects with light irides than in those with dark irides. CONCLUSIONS: Hartinger-measured accommodation provides more realistic measurement of accommodative amplitude than the subjective methods tested, especially in the presbyopic population. In presbyopic subjects, the subjective tests resulted in accommodative amplitudes up to 4.0 diopters greater than those measured with objective tests. Measurements of accommodative amplitude are best achieved with objective methods to stimulate and measure accommodation.

Accommodation, Ocular↗

Evaluation of a satisfied bilateral scleral expansion band patient.

PURPOSE: To measure accommodation subjectively and objectively in a satisfied bilateral scleral expansion band patient. SETTING: University of Houston, College of Optometry, Houston, Texas, USA. METHODS: One bilateral scleral expansion patient (age 50 years), 9 age-matched normal presbyopic control subjects (age range 48 to 52 years), and 1 normal control subject (age 27 years) participated. The scleral expansion patient had a complete eye examination, corneal topography, and wavefront measurements 19 months postoperatively. Accommodation was measured subjectively with the push-up technique, minus to blur, and dioptric range of clear vision. Accommodation was determined objectively by measuring the accommodative responses to negative lenses and pilocarpine 6% with a Hartinger coincidence refractometer and to real targets with a dynamic infrared optometer. RESULTS: Distance and near acuity of 20/20 was achieved with +1.00 diopter (D) in the left eye, +0.50 D in the right eye, and a near add of +2.25 D. Corneal topography and ocular aberration measurements revealed no suggestion of optical multifocality. Subjective measurements resulted in accommodative amplitudes of 1.50 to 4.00 D, and objective measurements resulted in amplitudes of 0.25 to 1.33 D. The PowerRefractor showed an accommodative response of 0.50 D to stimuli of 1.00 to 4.00 D and strong pupillary constriction with accommodative effort compared with the control. CONCLUSIONS: No increase in accommodative amplitude above normal age-matched controls was found. Patient satisfaction may have come from the high expectations this patient had for a positive surgery outcome.

Accommodation, Ocular↗

The effects of phenylephrine on pupil diameter and accommodation in rhesus monkeys.

PURPOSE: Phenylephrine is used to dilate the iris through alpha-adrenergic stimulation of the iris dilator muscle. Sympathetic stimulation of the ciliary muscle is believed to be inhibitory, decreasing accommodative amplitude. Investigations in humans have suggested some loss of functional accommodation after phenylephrine. It is unclear whether this loss is due to direct action of phenylephrine on the ciliary muscle or to secondary optical factors associated with mydriasis. The purpose of this study was to determine whether phenylephrine affects Edinger-Westphal (EW)-stimulated accommodation in rhesus monkeys. METHODS: The time course for maximum mydriasis was determined by videographic pupillography after phenylephrine instillation in 10 normal rhesus monkeys. Static and dynamic EW-stimulated accommodative responses were studied in five iridectomized rhesus monkeys before and after phenylephrine instillation. Accommodative amplitude was measured with a Hartinger coincidence refractometer. Dynamic accommodative responses were measured with infrared photorefraction, and functions were fitted to the data to determine peak velocity versus accommodative response relationships. RESULTS: The maximum dilated pupil diameter of 8.39 +/- 0.23 mm occurred 15 minutes after administration of phenylephrine. In iridectomized monkeys, postphenylephrine accommodative amplitudes were similar to prephenylephrine amplitudes. Dynamic analysis of the accommodative responses showed linear peak velocity versus accommodative amplitude relationships that were not statistically different before and after phenylephrine. CONCLUSIONS: alpha-Adrenergic stimulation causes a strong pupil dilation in noniridectomized monkey eyes but does not affect EW-stimulated accommodative amplitude or dynamics in anesthetized, iridectomized rhesus monkeys.

Accommodation, Ocular↗

Effects of pirenzepine on pupil size and accommodation in rhesus monkeys.

PURPOSE: Pirenzepine is suggested to be a relatively selective muscarinic (M(1)) antagonist and is currently under investigation for the treatment of myopia. Atropine, a nonselective M-type antagonist, is used in the treatment of myopia, but has undesired ocular and systemic side effects. An M(1)-specific antagonist may decrease side effects and remain effective at reducing the progression of myopia. In the current study, the effects of pirenzepine on pupil diameter, resting refraction, and accommodation were studied in rhesus monkeys. METHODS: The time course and extent of mydriasis from subconjunctival injection of 2% pirenzepine were determined in five normal rhesus monkeys, and the effects on static and dynamic accommodation were determined in four rhesus monkeys with permanent indwelling electrodes in the Edinger-Westphal (EW) nucleus of the midbrain. Subconjunctival injections of 0.0002% to 0.2% pirenzepine in log unit dilutions were tested in three monkeys to determine the effects on static EW-stimulated accommodation. At 40 to 50 minutes after pirenzepine injection, accommodation was stimulated pharmacologically in both eyes, and the response was measured for 30 minutes. RESULTS: After 2% pirenzepine injection, pupil size increased 2.02 +/- 0.41 mm, there was a hyperopic shift in resting refraction of 1.07 +/- 0.23 D, and nearly complete cycloplegia occurred. Maximum EW-stimulated accommodation was significantly decreased 20 to 40 minutes after 0.02% or greater pirenzepine. Carbachol-stimulated accommodation was significantly decreased after 0.2% or greater pirenzepine. CONCLUSIONS: Subconjunctival injections of 0.02% or greater pirenzepine result in a significant decrease in accommodation and are probably acting through nonselective muscarinic antagonism. Subconjunctival injections of 0.002% or less pirenzepine do not decrease EW-stimulated accommodation.

Accommodation, Ocular↗

Wave aberrations of the isolated crystalline lens.

A method to measure wave aberrations in the isolated crystalline lens is demonstrated. The method employs a laser scanning technique in which the trajectories of narrow refracted laser beams are measured for an array of sample positions incident on the lens. The local slope of the emerging wavefront is calculated for each sample position, and a least squares procedure is used to fit a Zernike polynomial function to define the wave aberration. Measurements of the aberrations of an isolated porcine lens and macaque lens undergoing changes in accommodative state with mechanical stretching are shown. Many aberrations were present, but negative spherical aberration dominated. In the macaque lens, many aberrations underwent systematic changes with accommodation, most notably the 4th order spherical aberration, which became more negative, and the 6th order spherical aberration, which progressed from negative to positive.

Accommodation, Ocular↗

Amplitude dependent accommodative dynamics in humans.

Dynamics of accommodation (far-to-near focus) and disaccommodation (near-to-far focus) are described as a function of response amplitude. Accommodative responses to step stimuli of various amplitudes presented in real space were measured in eight 20-30 year old subjects. Responses were fitted with exponential functions to determine amplitude, time constant and peak velocity. Despite the intersubject variability, the results show that time constants of accommodation and peak velocity of disaccommodation increase with amplitude in all subjects. The dynamics of accommodation and disaccommodation are dependent on amplitude, but have different properties in each case.

Accommodation, Ocular↗

Subjective and objective measurement of human accommodative amplitude.

PURPOSE: To assess objective and subjective methods to measure accommodation in a young human population. SETTING: Research laboratory, University of Houston, College of Optometry, Houston, Texas, USA. METHODS: Accommodation was measured in the right eye of 15 young subjects (9 women and 6 men) whose ages ranged from 23 to 28 years and 1 36-year-old subject. The mean age of all subjects was 26 years. Accommodation was stimulated and measured with 4 techniques. Two subjective measures (focometer and minus-lens procedures) were used. Accommodation was also stimulated with minus-lens-induced blur and with pilocarpine 6% and measured objectively with a Hartinger coincidence refractometer. RESULTS: Accommodative amplitudes measured with the 2 subjective methods agreed with each other but differed from the objectively measured amplitudes. Objectively measured accommodative amplitudes were similar in all subjects, with a mean of about 7.0 diopters. Accommodation stimulated with pilocarpine reached a maximum 33 minutes after administration. Individuals with light irides showed a stronger accommodative response to pilocarpine than subjects with dark irides. CONCLUSIONS: Subjective measures of accommodation tend to overestimate true accommodative amplitude. Methods exist to measure accommodation objectively. These include stimulating accommodation with trial lenses or pilocarpine 6% and measuring the accommodative response with an objective optometer such as a Hartinger coincidence refractometer. Objective measures of accommodation should be used to determine whether accommodation can be restored in presbyopes.

Accommodation, Ocular↗

Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry.

PURPOSE: Prior studies in humans measured time constants of biometric accommodative changes as a function of amplitude, and prior studies in monkeys used slit lamp videography to analyze dynamic lenticular accommodative movements. Neither of these studies related biometric changes to refractive changes. We wished to develop and test methodology to begin to test the hypothesis that ocular biometric changes are well correlated with accommodative refractive changes in rhesus monkeys. METHODS: Methodology is described to dynamically measure biometric accommodative changes with A-scan ultrasonography. Lens thickness, anterior chamber depth, and anterior segment length (anterior chamber depth plus lens thickness) were measured dynamically during Edinger-Westphal-stimulated accommodation in two eyes of one rhesus monkey. In addition, dynamic accommodative refractive changes were measured with infrared photorefraction. Functions were fit to the accommodative and disaccommodative responses to obtain time constants. Derivatives of these functions allow peak velocities to be determined for each amplitude. Dynamic changes in lens thickness and anterior chamber depth measured with A-scan biometry were compared with dynamic measures of accommodation using infrared photorefraction. RESULTS: Lens thickness and anterior segment length increase and anterior chamber depth decreases during accommodation. The biometric changes are well correlated with the accommodative optical changes. Peak velocities of accommodative changes in lens thickness and anterior chamber depth increase with amplitude and peak velocities for disaccommodation were higher than those for accommodation. CONCLUSIONS: Dynamic A-scan provides a method for dynamic analysis of the accommodative biometric changes during Edinger-Westphal-stimulated accommodation in monkeys, although the measurement resolution of this approach is limited.

Accommodation, Ocular↗

Dynamic accommodation in rhesus monkeys.

The dynamics of Edinger-Westphal (EW) stimulated accommodation were studied in two young rhesus monkeys to understand the relationships between accommodative amplitude and rates of accommodation and disaccommodation. Accommodative responses were recorded with infrared photorefraction at five different amplitudes spanning the full EW stimulated accommodative range available to each eye. Combined exponential and polynomial functions were fit to the accommodation and disaccommodation responses. Derivatives of these functions provided the maximum rates of accommodation and disaccommodation as well as time constants for each amplitude. Maximum rates of EW stimulated accommodation and disaccommodation were found to increase linearly with amplitudes from 0.58 to 17.41 D in the two monkeys. The results suggests that the rate of EW stimulated accommodation is dictated by the amplitude. We conclude that if dynamic accommodative responses are to be compared in monkeys of different ages it is necessary to compare responses for the same accommodative amplitudes in order to draw conclusions about age related changes.

Accommodation, Ocular↗